In this paper we use trellis coded amplitude modulation (TC-AM) as models to analyze the receivers with intersymbol interference (ISI) under BPSK and π/4-QPSK modulations.Using the modified generating function and th...In this paper we use trellis coded amplitude modulation (TC-AM) as models to analyze the receivers with intersymbol interference (ISI) under BPSK and π/4-QPSK modulations.Using the modified generating function and the weight profile function of the TC-AM,the bit error probability for both cases is evaluated in the sense of maximum likelihood decoding.The numerical result is given.展开更多
Objective: To observe the expression of Resistin mRNA in peripheral blood mononuclear cells and its gene poly-morphism in coding region in a small range population in Zhejiang Province of China. Methods: Eighty-three ...Objective: To observe the expression of Resistin mRNA in peripheral blood mononuclear cells and its gene poly-morphism in coding region in a small range population in Zhejiang Province of China. Methods: Eighty-three cases of type 2 diabetes mellitus and 53 healthy people were included. The expression of Resistin mRNA in peripheral blood mononuclear cells was detected by RT-PCR and semi-quantitative PCR assay. The sequencing work was done in Resistin cDNA and gene poly-morphism was analyzed. Results: At the same condition, in 83 diabetes patients, Resistin mRNA was detected in 23 cases (11 males and 12 females). There was no Resistin mRNA expression in 53 healthy people. The ratio of PCR products between Resistin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was from 0.564 to 1.238, averaging 0.804±0.436. The sequence of Resistin cDNA is almost identical with each other and with that in GenBank with no single nucleotide polymorphism being found. Conclusion: Resistin mRNA is expressed in human peripheral blood mononuclear cells in some type 2 diabetes mellitus, but its expression is at a low level. Among the experiment population we did not find polymorphism phenomenon in Resistin coding region. The different individual’s Resistin coding region is highly coincident.展开更多
The pattern of codon usage in the chloroplast genome of Populus alba was investigated. Correspondence analysis (a commonly used multivariate statistical approach) and method of effective number of codons (ENc)-plo...The pattern of codon usage in the chloroplast genome of Populus alba was investigated. Correspondence analysis (a commonly used multivariate statistical approach) and method of effective number of codons (ENc)-plot were conducted to analyze synonymous codon usage. The results of correspondence analysis showed that the distribution of genes on the major axis was significantly correlated with the frequency of use of G+C in synonymously variable third position of sense codon (GC3S), (r=0.349), and the positions of genes on the axis 2 and axis 3 were significantly correlated with CAI (r=-0.348, p〈0.01 and r=0.602, p〈0.01). The ENc for most genes was similar to that for the expected ENc based on the GC3s, but several genes with low ENc values were lying below the expected curve. All of these data indicated that codon usage was dominated by a mutational bias in chloroplast gcnome ofP. alba. The selection in nature for translational efficiency only played a minor role in shaping codon usage in the chloroplast genome ofP alba.展开更多
Laser assisted turning (LAT) is one of the advanced machining technologies, which uses laser power to heat the surface of a workpiece before the material is removed. It has several advantages of low manufacturing co...Laser assisted turning (LAT) is one of the advanced machining technologies, which uses laser power to heat the surface of a workpiece before the material is removed. It has several advantages of low manufacturing costs, high productivity and high qualities to machine difficult-to-cut materials such as silicon nitride, muUite, zirconia and Ni. A large part of studies on LAT have been focused on a round bar. With increasing demands for high quality products and high performance engineering system, the researches on LAT for clover and square section members are necessary. But, these workpieces are impossible to be machined on conventional CNC lathe and to generate NC code with current CAM softwares. As a basic research for combining LAT with a tilting index table type 5-axis machining center, i.e. laser assisted turn-mill, a new method is suggested to generate NC code that can process various types of clover and square section members through development of C++ program.展开更多
An intelligent detecting system based on wireless transmission is designed. Its hardware includes the card reading module, the wireless digital transmission module, the LCD module, the random password keyboard module ...An intelligent detecting system based on wireless transmission is designed. Its hardware includes the card reading module, the wireless digital transmission module, the LCD module, the random password keyboard module and a 16×16 lattice word database based on e-Flash MM36SB020. Its software is a communication protocol between the central control computer and the entrance management base station. To resolve the conflicting problems occurred during the data transmission, a method of delaying time at random is proposed.展开更多
The study of cyclic codes over rings has generated a lot of public interest.In this paper,we study cyclic codes and their dual codes over the ring Z P2 of length pe,and find a set of generators for these codes.The ran...The study of cyclic codes over rings has generated a lot of public interest.In this paper,we study cyclic codes and their dual codes over the ring Z P2 of length pe,and find a set of generators for these codes.The ranks and minimal generator sets of these codes are studied as well,which play an important role in decoding and determining the distance distribution of codes.展开更多
Overlapped x domain multiplexing(OVXDM) is a promising encoding technique to obtain high spectral efficiency by utilizing inter-symbol interference(ISI) intelligently. However, the computational complexity of maximum ...Overlapped x domain multiplexing(OVXDM) is a promising encoding technique to obtain high spectral efficiency by utilizing inter-symbol interference(ISI) intelligently. However, the computational complexity of maximum likelihood sequence detection(MLSD) increases exponentially with the growth of spectral efficiency in OVXDM, which is unbearable for practical implementations. In this paper, based on a novel path metric associating adjacent symbols, we propose a multi-bit sliding stack decoding(Multi-Bit SSD) algorithm to achieve multiple-bit decoding simultaneously in OVXDM. Theoretical analysis is provided for the algorithm, which indicates the relationship between the performance and parameters including multiplexing waveform, overlapping fold and sliding window size. Simulation results show that the proposed algorithm can achieve better decoding performance and higher spectral efficiency than conventional fast decoding algorithms.展开更多
Foreign language teachers' codeswitching (CS) between Foreign Language (FL) and Mother Tongue (MT) in class has been under discussion for years. Out of the pedagogical concern, many teaching practitioners condu...Foreign language teachers' codeswitching (CS) between Foreign Language (FL) and Mother Tongue (MT) in class has been under discussion for years. Out of the pedagogical concern, many teaching practitioners conducted various studies in different contexts aiming at describing, quantifying, and interpreting teachers' CS between FL and MT in class. However, up till now little attention is paid to students' perceptions and understandings of teachers' CS, which may help improve educators' understanding of the phenomenon in FL classrooms. This paper presents the result of two focus group interviews with groups of Chinese university students at their third and fourth year of college. Following a formal interview outline, issues on students' recall, understanding and evaluation of teachers' CS are addressed in the interview. Based on the analysis of the interviews, a better understanding on foreign language teachers' CS is gained, and students' perceptions on teachers' purposes and reasons for CS are drawn. A framework for investigating foreign language teachers' CS in Chinese universities is proposed with two hypotheses generated.展开更多
A low computational cost cancelable fingerprint template, namely the multi-line codes was proposed. The formulation of a single-line code involves the inspection of minutiae distribution along a straight line construc...A low computational cost cancelable fingerprint template, namely the multi-line codes was proposed. The formulation of a single-line code involves the inspection of minutiae distribution along a straight line constructed based on the reference minutia. Multi-line code is introduced to elevate the performance by combining several single-line codes. Experiments were carried out on a few FVC databases. It has been proven that the proposed method yields relatively low computational complexity as compared to existing minutiae distribution-based methods, while preserving the performance. The equal error rate obtained for FVC2002 DB1 is 4.69% in stolen-key case, and the total arithmetic operations utilized are 14 520 additions and zero multiplication.展开更多
A new method for the construction of the high performance systematic irregular low-density paritycheck (LDPC) codes based on the sparse generator matrix (G-LDPC) is introduced. The code can greatly reduce the enco...A new method for the construction of the high performance systematic irregular low-density paritycheck (LDPC) codes based on the sparse generator matrix (G-LDPC) is introduced. The code can greatly reduce the encoding complexity while maintaining the same decoding complexity as traditional regular LDPC (H-LDPC) codes defined by the sparse parity check matrix. Simulation results show that the performance of the proposed irregular LDPC codes can offer significant gains over traditional LDPC codes in low SNRs with a few decoding iterations over an additive white Gaussian noise (AWGN) channel.展开更多
We investigated the allelopathic properties of Alexandrium tamarense(Laboar) Balech on the growth of Prorocentrum donghaiense Lu,Chattonella marina(Subrahmanyan) Hara et Chihara and Heterosigma akashiwo(Hada) Hada in ...We investigated the allelopathic properties of Alexandrium tamarense(Laboar) Balech on the growth of Prorocentrum donghaiense Lu,Chattonella marina(Subrahmanyan) Hara et Chihara and Heterosigma akashiwo(Hada) Hada in a laboratory experiment.We examined the growth of A.tamarense,C.marina,P.donghaiense and H.Akashiwo in co-cultures and the effect of filtrates from A.tamarense cultures in various growth phases,on the three harmful algal bloom(HAB)-forming algae.In co-cultures with A.tamarense,both C.marina and H.akashiwo were dramatically suppressed at high cell densities;in contrast,the growth of P.donghaiense varied in different inoculative ratios of A.tamarense and P.donghaiense.When the ratio was 1:1(P.donghaiense:A.tamarense),growth of P.donghaiense was inhibited considerably,while the growth of P.donghaiense was almost the same as that of the control when the ratio was 9:1.The growth difference of P.donghaiense,C.marina and H.akashiwo when co-cultured with A.tamarense indicated that the allelopathic effect may be one of the important factors in algal competition and phytoplankton succession involving A.tamarense.In addition,the filtrate from A.tamarense culture had negative impacts on these three HAB algae,and such inhibition varied with different growth phases of A.tamarense in parallel with reported values of PSP toxin content in Alexandrium cells.This implied that PSP toxin was possibly involved in allelopathy of A.tamarense.However,the rapid decomposition and inactivation of PSP toxin above pH7 weakened this possibility.Further studies on the allelochemicals responsible for the allelopathy of A.tamarense need to be carried out in future.展开更多
Long non-coding RNAs (IncRNAs), gradually being paid attention to, have been found playing a critical role in regulation of cellular processes such as cell growth and apoptosis, what is more, accumulating evidence i...Long non-coding RNAs (IncRNAs), gradually being paid attention to, have been found playing a critical role in regulation of cellular processes such as cell growth and apoptosis, what is more, accumulating evidence indicates that IncRNAs also play a critical role in regulation of carcinogenesis and cancer progression. Here, we will summarize the recent researches about some IncRNAs in the development of cancers, hoping to give a new view about the study in the mechanisms involved in carcinogenesis and tumor progression.展开更多
MicroRNAs (miRNAs), approximately 21 to 23 nucleotides (nt) in length, belong to a set of smal non-coding RNA molecules that were not thought to be functional until the recent decades. miRNAs play important roles ...MicroRNAs (miRNAs), approximately 21 to 23 nucleotides (nt) in length, belong to a set of smal non-coding RNA molecules that were not thought to be functional until the recent decades. miRNAs play important roles in many diseases such as various kinds of cancers and immune disorders. Many studies have focused on the relationship between miRNAs and diseases. miRNAs are significant mediators in human growth and development and in the genesis and development of diseases. Almost 30% of the activity of protein-coding genes is forecasted to be regulated by miRNAs in mammals, and some miRNAs are regarded as potential therapeutic targets for various diseases. In this review, we outline some functions of miRNAs, especialy those related to diseases.展开更多
The famous Square attacks against the Rijndael algorithm have taken advantage of the change of the balance of some bytes. Further study shows that the change of activity always happens before the change of balance, wh...The famous Square attacks against the Rijndael algorithm have taken advantage of the change of the balance of some bytes. Further study shows that the change of activity always happens before the change of balance, which builds the foundation for a new activity attack presented in this paper. In the activity attack, the round in which the activity changes is executed in an equivalent form to avoid the obstructive restriction of the subkeys of that round.The existence of the birthday paradox guarantees much fewer plaintexts necessary for activity attacks comparing with that for corresponding Square attacks. But no benefit may result from the new attacks performed independently because the activity attacks guess four instead of one key byte once. Only when both the balance property and the activity property are exploited at the same time can much better performance be obtained. The better performance in the simulation shows that the consuming time and chosen plaintexts necessary are both reduced to one tenth of those of the corresponding Square attacks. So the activity attacks could be viewed as an efficient supplement to the Square attacks.展开更多
We link nuclear force with gravity. We use statistical entropy to link fine-structure constant (ct) and cosmological constant, showing mystical number 137 (as reciprocal of increasing entropy of the universe) as n...We link nuclear force with gravity. We use statistical entropy to link fine-structure constant (ct) and cosmological constant, showing mystical number 137 (as reciprocal of increasing entropy of the universe) as negative entropy needed for life to exist. If our computational route applies to the physical universe, it should apply to life. Molecular biology is searching for the fundamental source of information that would link to the information in DNA.展开更多
DNA computing is a novel method for solving a class of intractable computational problem, in which the computing can grow exponentially with problem size. Up to now, many accomplishments have been achieved to improve ...DNA computing is a novel method for solving a class of intractable computational problem, in which the computing can grow exponentially with problem size. Up to now, many accomplishments have been achieved to improve its performance and increase its reliability. Hamilton Graph Problem has been solved by means of molecular biology techniques. A small graph was encoded in molecules of DNA, and the 'operations' of the computation were performed with standard protocols and enzymes. This work represents further evidence for the ability of DNA computing to solve NP-complete search problems.展开更多
AIM: To approach the elusive function of the SLA/LP molecule, we have characterized genomic organization and conservation of the major antigenic and functional properties of the SLA/LP molecule in various species. ME...AIM: To approach the elusive function of the SLA/LP molecule, we have characterized genomic organization and conservation of the major antigenic and functional properties of the SLA/LP molecule in various species. METHODS: By means of computational biology, we have characterized the complete SLA/LP gene, mRNA and deduced protein sequences in man, mouse, zebrafish, fly, and worm. RESULTS: The human SLA/LP gene sequence of approximately 39 kb, which maps to chromosome 4p15.2, is organized in 11 exons, of which 10 or 11 are translated, depending on the splice variant. Homologous molecules were identified in several biological model organisms. The various homologous protein sequences showed a high degree of similarity or homology, notably at those residues that are of functional importance. The only domain of the human protein sequence that lacks significant homology with homologous sequences is the major antigenic epitope recognized by autoantibodies from autoimmune hepatitis (AIH) patients. CONCLUSION: The SLA/LP molecule and its functionally relevant residues have been highly conserved throughout the evoluti n, suggesting an indispensable function of the molecule. The finding that the only non-conserved domain is the dominant antigenic epitope of the human SLA/LP sequence, suggests that SLA/LP autoimmunity is autoantigen-driven rather than being driven by molecular mimicry.展开更多
This paper deals with a problem of application generation together with their Graphic User Interface (GUI). Particularly, the source code generator based on dynamic frames was improved for more effective specificati...This paper deals with a problem of application generation together with their Graphic User Interface (GUI). Particularly, the source code generator based on dynamic frames was improved for more effective specification of GUI. It's too demanding for the developers to have specification of the application that contain all physical coordinates and other details of buttons and other GUI elements. The developed solution for this problem is based on post-processing of generated source code using iterators for specifying coordinates and other values of graphic elements. The paper includes two examples of generating web applications and their GUI.展开更多
We present a global optimization method, called the real-code genetic algorithm (RGA), to the ground state energies. The proposed method does not require partial derivatives with respect to each variational parameter ...We present a global optimization method, called the real-code genetic algorithm (RGA), to the ground state energies. The proposed method does not require partial derivatives with respect to each variational parameter or solving an eigenequation, so the present method overcomes the major difficulties of the variational method. RGAs also do not require coding and encoding procedures, so the computation time and complexity are reduced. The ground state energies of hydrogenic donors in GaAs-(Ga,Al)As quantum dots have been calculated for a range of the radius of the quantum dot radii of practical interest. They are compared with those obtained by the variational method. The results obtained demonstrate the proposed method is simple, accurate, and easy implement.展开更多
文摘In this paper we use trellis coded amplitude modulation (TC-AM) as models to analyze the receivers with intersymbol interference (ISI) under BPSK and π/4-QPSK modulations.Using the modified generating function and the weight profile function of the TC-AM,the bit error probability for both cases is evaluated in the sense of maximum likelihood decoding.The numerical result is given.
基金Project (No. 2003C33031) supported by the Science and Technology Department of Zhejiang Province, China
文摘Objective: To observe the expression of Resistin mRNA in peripheral blood mononuclear cells and its gene poly-morphism in coding region in a small range population in Zhejiang Province of China. Methods: Eighty-three cases of type 2 diabetes mellitus and 53 healthy people were included. The expression of Resistin mRNA in peripheral blood mononuclear cells was detected by RT-PCR and semi-quantitative PCR assay. The sequencing work was done in Resistin cDNA and gene poly-morphism was analyzed. Results: At the same condition, in 83 diabetes patients, Resistin mRNA was detected in 23 cases (11 males and 12 females). There was no Resistin mRNA expression in 53 healthy people. The ratio of PCR products between Resistin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was from 0.564 to 1.238, averaging 0.804±0.436. The sequence of Resistin cDNA is almost identical with each other and with that in GenBank with no single nucleotide polymorphism being found. Conclusion: Resistin mRNA is expressed in human peripheral blood mononuclear cells in some type 2 diabetes mellitus, but its expression is at a low level. Among the experiment population we did not find polymorphism phenomenon in Resistin coding region. The different individual’s Resistin coding region is highly coincident.
基金supported by the National High Tech Development Project of Chinathe 863 Program (Grant Nos.2007AA02Z329)the National Natural Science Foundation of China (Grant Nos.20060213024).
文摘The pattern of codon usage in the chloroplast genome of Populus alba was investigated. Correspondence analysis (a commonly used multivariate statistical approach) and method of effective number of codons (ENc)-plot were conducted to analyze synonymous codon usage. The results of correspondence analysis showed that the distribution of genes on the major axis was significantly correlated with the frequency of use of G+C in synonymously variable third position of sense codon (GC3S), (r=0.349), and the positions of genes on the axis 2 and axis 3 were significantly correlated with CAI (r=-0.348, p〈0.01 and r=0.602, p〈0.01). The ENc for most genes was similar to that for the expected ENc based on the GC3s, but several genes with low ENc values were lying below the expected curve. All of these data indicated that codon usage was dominated by a mutational bias in chloroplast gcnome ofP. alba. The selection in nature for translational efficiency only played a minor role in shaping codon usage in the chloroplast genome ofP alba.
基金Project(2011-0017407)supported by the National Research Foundation of Korea(NRF)funded by Korea government(MEST)
文摘Laser assisted turning (LAT) is one of the advanced machining technologies, which uses laser power to heat the surface of a workpiece before the material is removed. It has several advantages of low manufacturing costs, high productivity and high qualities to machine difficult-to-cut materials such as silicon nitride, muUite, zirconia and Ni. A large part of studies on LAT have been focused on a round bar. With increasing demands for high quality products and high performance engineering system, the researches on LAT for clover and square section members are necessary. But, these workpieces are impossible to be machined on conventional CNC lathe and to generate NC code with current CAM softwares. As a basic research for combining LAT with a tilting index table type 5-axis machining center, i.e. laser assisted turn-mill, a new method is suggested to generate NC code that can process various types of clover and square section members through development of C++ program.
文摘An intelligent detecting system based on wireless transmission is designed. Its hardware includes the card reading module, the wireless digital transmission module, the LCD module, the random password keyboard module and a 16×16 lattice word database based on e-Flash MM36SB020. Its software is a communication protocol between the central control computer and the entrance management base station. To resolve the conflicting problems occurred during the data transmission, a method of delaying time at random is proposed.
基金the National Natural Science Foundation of China(No.60673074)the Key Project of Ministry of Education Science and Technology’s Research(107065)
文摘The study of cyclic codes over rings has generated a lot of public interest.In this paper,we study cyclic codes and their dual codes over the ring Z P2 of length pe,and find a set of generators for these codes.The ranks and minimal generator sets of these codes are studied as well,which play an important role in decoding and determining the distance distribution of codes.
基金supported by the Fundamental Research Funds for the Central Universities under grant 2016XD-01
文摘Overlapped x domain multiplexing(OVXDM) is a promising encoding technique to obtain high spectral efficiency by utilizing inter-symbol interference(ISI) intelligently. However, the computational complexity of maximum likelihood sequence detection(MLSD) increases exponentially with the growth of spectral efficiency in OVXDM, which is unbearable for practical implementations. In this paper, based on a novel path metric associating adjacent symbols, we propose a multi-bit sliding stack decoding(Multi-Bit SSD) algorithm to achieve multiple-bit decoding simultaneously in OVXDM. Theoretical analysis is provided for the algorithm, which indicates the relationship between the performance and parameters including multiplexing waveform, overlapping fold and sliding window size. Simulation results show that the proposed algorithm can achieve better decoding performance and higher spectral efficiency than conventional fast decoding algorithms.
文摘Foreign language teachers' codeswitching (CS) between Foreign Language (FL) and Mother Tongue (MT) in class has been under discussion for years. Out of the pedagogical concern, many teaching practitioners conducted various studies in different contexts aiming at describing, quantifying, and interpreting teachers' CS between FL and MT in class. However, up till now little attention is paid to students' perceptions and understandings of teachers' CS, which may help improve educators' understanding of the phenomenon in FL classrooms. This paper presents the result of two focus group interviews with groups of Chinese university students at their third and fourth year of college. Following a formal interview outline, issues on students' recall, understanding and evaluation of teachers' CS are addressed in the interview. Based on the analysis of the interviews, a better understanding on foreign language teachers' CS is gained, and students' perceptions on teachers' purposes and reasons for CS are drawn. A framework for investigating foreign language teachers' CS in Chinese universities is proposed with two hypotheses generated.
文摘A low computational cost cancelable fingerprint template, namely the multi-line codes was proposed. The formulation of a single-line code involves the inspection of minutiae distribution along a straight line constructed based on the reference minutia. Multi-line code is introduced to elevate the performance by combining several single-line codes. Experiments were carried out on a few FVC databases. It has been proven that the proposed method yields relatively low computational complexity as compared to existing minutiae distribution-based methods, while preserving the performance. The equal error rate obtained for FVC2002 DB1 is 4.69% in stolen-key case, and the total arithmetic operations utilized are 14 520 additions and zero multiplication.
文摘A new method for the construction of the high performance systematic irregular low-density paritycheck (LDPC) codes based on the sparse generator matrix (G-LDPC) is introduced. The code can greatly reduce the encoding complexity while maintaining the same decoding complexity as traditional regular LDPC (H-LDPC) codes defined by the sparse parity check matrix. Simulation results show that the performance of the proposed irregular LDPC codes can offer significant gains over traditional LDPC codes in low SNRs with a few decoding iterations over an additive white Gaussian noise (AWGN) channel.
基金Supported by the NSFC-Guangdong Province Association Foundation(No.U0733006)the National Natural Science Foundation of China(No.30970502,40976065)the National Basic Research Program of China(973 Program)(No.2010CB428702)
文摘We investigated the allelopathic properties of Alexandrium tamarense(Laboar) Balech on the growth of Prorocentrum donghaiense Lu,Chattonella marina(Subrahmanyan) Hara et Chihara and Heterosigma akashiwo(Hada) Hada in a laboratory experiment.We examined the growth of A.tamarense,C.marina,P.donghaiense and H.Akashiwo in co-cultures and the effect of filtrates from A.tamarense cultures in various growth phases,on the three harmful algal bloom(HAB)-forming algae.In co-cultures with A.tamarense,both C.marina and H.akashiwo were dramatically suppressed at high cell densities;in contrast,the growth of P.donghaiense varied in different inoculative ratios of A.tamarense and P.donghaiense.When the ratio was 1:1(P.donghaiense:A.tamarense),growth of P.donghaiense was inhibited considerably,while the growth of P.donghaiense was almost the same as that of the control when the ratio was 9:1.The growth difference of P.donghaiense,C.marina and H.akashiwo when co-cultured with A.tamarense indicated that the allelopathic effect may be one of the important factors in algal competition and phytoplankton succession involving A.tamarense.In addition,the filtrate from A.tamarense culture had negative impacts on these three HAB algae,and such inhibition varied with different growth phases of A.tamarense in parallel with reported values of PSP toxin content in Alexandrium cells.This implied that PSP toxin was possibly involved in allelopathy of A.tamarense.However,the rapid decomposition and inactivation of PSP toxin above pH7 weakened this possibility.Further studies on the allelochemicals responsible for the allelopathy of A.tamarense need to be carried out in future.
文摘Long non-coding RNAs (IncRNAs), gradually being paid attention to, have been found playing a critical role in regulation of cellular processes such as cell growth and apoptosis, what is more, accumulating evidence indicates that IncRNAs also play a critical role in regulation of carcinogenesis and cancer progression. Here, we will summarize the recent researches about some IncRNAs in the development of cancers, hoping to give a new view about the study in the mechanisms involved in carcinogenesis and tumor progression.
基金Supported by a grant from the Natural Science Foundation of Hebei Province(No.C2009001151)
文摘MicroRNAs (miRNAs), approximately 21 to 23 nucleotides (nt) in length, belong to a set of smal non-coding RNA molecules that were not thought to be functional until the recent decades. miRNAs play important roles in many diseases such as various kinds of cancers and immune disorders. Many studies have focused on the relationship between miRNAs and diseases. miRNAs are significant mediators in human growth and development and in the genesis and development of diseases. Almost 30% of the activity of protein-coding genes is forecasted to be regulated by miRNAs in mammals, and some miRNAs are regarded as potential therapeutic targets for various diseases. In this review, we outline some functions of miRNAs, especialy those related to diseases.
基金the National 973 Project(G1999035803)National 863 Grand Project(2002AA143021)and the National Cryptography Development Funds for the Tenth Five-year Project
文摘The famous Square attacks against the Rijndael algorithm have taken advantage of the change of the balance of some bytes. Further study shows that the change of activity always happens before the change of balance, which builds the foundation for a new activity attack presented in this paper. In the activity attack, the round in which the activity changes is executed in an equivalent form to avoid the obstructive restriction of the subkeys of that round.The existence of the birthday paradox guarantees much fewer plaintexts necessary for activity attacks comparing with that for corresponding Square attacks. But no benefit may result from the new attacks performed independently because the activity attacks guess four instead of one key byte once. Only when both the balance property and the activity property are exploited at the same time can much better performance be obtained. The better performance in the simulation shows that the consuming time and chosen plaintexts necessary are both reduced to one tenth of those of the corresponding Square attacks. So the activity attacks could be viewed as an efficient supplement to the Square attacks.
文摘We link nuclear force with gravity. We use statistical entropy to link fine-structure constant (ct) and cosmological constant, showing mystical number 137 (as reciprocal of increasing entropy of the universe) as negative entropy needed for life to exist. If our computational route applies to the physical universe, it should apply to life. Molecular biology is searching for the fundamental source of information that would link to the information in DNA.
基金Supported by the CNSF(60274026 60174047+1 种基金 30370356) Supported by the Anhui Provinc'e Educational Committee Foundation(2003Kj098)
文摘DNA computing is a novel method for solving a class of intractable computational problem, in which the computing can grow exponentially with problem size. Up to now, many accomplishments have been achieved to improve its performance and increase its reliability. Hamilton Graph Problem has been solved by means of molecular biology techniques. A small graph was encoded in molecules of DNA, and the 'operations' of the computation were performed with standard protocols and enzymes. This work represents further evidence for the ability of DNA computing to solve NP-complete search problems.
基金Supported by the Deutsche Forschungsgemeinschaft(SFB 548)
文摘AIM: To approach the elusive function of the SLA/LP molecule, we have characterized genomic organization and conservation of the major antigenic and functional properties of the SLA/LP molecule in various species. METHODS: By means of computational biology, we have characterized the complete SLA/LP gene, mRNA and deduced protein sequences in man, mouse, zebrafish, fly, and worm. RESULTS: The human SLA/LP gene sequence of approximately 39 kb, which maps to chromosome 4p15.2, is organized in 11 exons, of which 10 or 11 are translated, depending on the splice variant. Homologous molecules were identified in several biological model organisms. The various homologous protein sequences showed a high degree of similarity or homology, notably at those residues that are of functional importance. The only domain of the human protein sequence that lacks significant homology with homologous sequences is the major antigenic epitope recognized by autoantibodies from autoimmune hepatitis (AIH) patients. CONCLUSION: The SLA/LP molecule and its functionally relevant residues have been highly conserved throughout the evoluti n, suggesting an indispensable function of the molecule. The finding that the only non-conserved domain is the dominant antigenic epitope of the human SLA/LP sequence, suggests that SLA/LP autoimmunity is autoantigen-driven rather than being driven by molecular mimicry.
文摘This paper deals with a problem of application generation together with their Graphic User Interface (GUI). Particularly, the source code generator based on dynamic frames was improved for more effective specification of GUI. It's too demanding for the developers to have specification of the application that contain all physical coordinates and other details of buttons and other GUI elements. The developed solution for this problem is based on post-processing of generated source code using iterators for specifying coordinates and other values of graphic elements. The paper includes two examples of generating web applications and their GUI.
文摘We present a global optimization method, called the real-code genetic algorithm (RGA), to the ground state energies. The proposed method does not require partial derivatives with respect to each variational parameter or solving an eigenequation, so the present method overcomes the major difficulties of the variational method. RGAs also do not require coding and encoding procedures, so the computation time and complexity are reduced. The ground state energies of hydrogenic donors in GaAs-(Ga,Al)As quantum dots have been calculated for a range of the radius of the quantum dot radii of practical interest. They are compared with those obtained by the variational method. The results obtained demonstrate the proposed method is simple, accurate, and easy implement.