目的 分析2型糖尿病患者接受甘精胰岛素联合阿卡波糖治疗干预的疗效。方法 200例2型糖尿病患者,根据治疗方式不同将其分为对照组与观察组,各100例。对照组患者接受阿卡波糖治疗,观察组患者行甘精胰岛素联合阿卡波糖治疗。观察两组患者...目的 分析2型糖尿病患者接受甘精胰岛素联合阿卡波糖治疗干预的疗效。方法 200例2型糖尿病患者,根据治疗方式不同将其分为对照组与观察组,各100例。对照组患者接受阿卡波糖治疗,观察组患者行甘精胰岛素联合阿卡波糖治疗。观察两组患者临床疗效、治疗前后血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]水平与不良反应发生情况。结果 观察组临床治疗总有效率为94.00%,高于对照组的60.00%,差异有统计学意义(P<0.05)。治疗后,观察组FPG、2 h PG、HbA1c水平分别为(6.22±2.01)mmol/L、(8.63±2.94)mmol/L、(6.01±1.98)%,对照组分别为(8.27±2.05)mmol/L、(10.62±3.02)mmol/L、(8.10±2.10)%。两组FPG、2 h PG、HbA1c水平均较治疗前降低且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为2.00%,低于对照组的18.00%,差异有统计学意义(P<0.05)。结论 针对2型糖尿病给予其甘精胰岛素联合阿卡波糖治疗,能够有效改善患者的各项血糖水平,减少治疗期间的不良反应发生率,用药安全指数较高,有效提升治疗效果,值得在临床上推广应用。展开更多
With the acceleration of society’s aging process,the widespread phenomenon of polypharmacy among the elderly has become a significant concern.This research aimed to analyze potential inappropriate medication among 17...With the acceleration of society’s aging process,the widespread phenomenon of polypharmacy among the elderly has become a significant concern.This research aimed to analyze potential inappropriate medication among 178 inpatients in the geriatric general department of our hospital from January 2022 to September 2022.The participants were randomly assigned to an observation group and a control group.The observation group received pharmaceutical intervention,whereas the control group did not.The objective was to explore the impact of pharmaceutical intervention on polypharmacy in this population.The results revealed that after pharmaceutical intervention,there were no significant differences in medication adherence,medication appropriateness index(MAI),quantity of medicine,and potentially inappropriate medication(PIM)in the control group compared to before the intervention(P>0.05).However,the observation group showed significant improvement(P<0.05).The proportion of patients with good adherence increased from 57%to 78%,and the percentage of patients with MAI scores over 10 decreased from 60%to 40%.Moreover,there was a reduction in the number of medications prescribed,with only 47%of patients receiving more than five different types compared to the initial rate of 64%.Additionally,the occurrence of PIM declined from an initial rate of 64%to just 44%,surpassing that observed in the control group.Therefore,the implementation of pharmaceutical intervention can effectively enhance medication adherence and appropriateness among elderly patients,mitigate the risk of PIM,and promote rational medicine utilization.展开更多
文摘目的 分析2型糖尿病患者接受甘精胰岛素联合阿卡波糖治疗干预的疗效。方法 200例2型糖尿病患者,根据治疗方式不同将其分为对照组与观察组,各100例。对照组患者接受阿卡波糖治疗,观察组患者行甘精胰岛素联合阿卡波糖治疗。观察两组患者临床疗效、治疗前后血糖指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]水平与不良反应发生情况。结果 观察组临床治疗总有效率为94.00%,高于对照组的60.00%,差异有统计学意义(P<0.05)。治疗后,观察组FPG、2 h PG、HbA1c水平分别为(6.22±2.01)mmol/L、(8.63±2.94)mmol/L、(6.01±1.98)%,对照组分别为(8.27±2.05)mmol/L、(10.62±3.02)mmol/L、(8.10±2.10)%。两组FPG、2 h PG、HbA1c水平均较治疗前降低且观察组低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为2.00%,低于对照组的18.00%,差异有统计学意义(P<0.05)。结论 针对2型糖尿病给予其甘精胰岛素联合阿卡波糖治疗,能够有效改善患者的各项血糖水平,减少治疗期间的不良反应发生率,用药安全指数较高,有效提升治疗效果,值得在临床上推广应用。
基金Hospital Pharmacy Research Foundation of Guangdong(Grant No.2022A14)。
文摘With the acceleration of society’s aging process,the widespread phenomenon of polypharmacy among the elderly has become a significant concern.This research aimed to analyze potential inappropriate medication among 178 inpatients in the geriatric general department of our hospital from January 2022 to September 2022.The participants were randomly assigned to an observation group and a control group.The observation group received pharmaceutical intervention,whereas the control group did not.The objective was to explore the impact of pharmaceutical intervention on polypharmacy in this population.The results revealed that after pharmaceutical intervention,there were no significant differences in medication adherence,medication appropriateness index(MAI),quantity of medicine,and potentially inappropriate medication(PIM)in the control group compared to before the intervention(P>0.05).However,the observation group showed significant improvement(P<0.05).The proportion of patients with good adherence increased from 57%to 78%,and the percentage of patients with MAI scores over 10 decreased from 60%to 40%.Moreover,there was a reduction in the number of medications prescribed,with only 47%of patients receiving more than five different types compared to the initial rate of 64%.Additionally,the occurrence of PIM declined from an initial rate of 64%to just 44%,surpassing that observed in the control group.Therefore,the implementation of pharmaceutical intervention can effectively enhance medication adherence and appropriateness among elderly patients,mitigate the risk of PIM,and promote rational medicine utilization.
