Alcohol consumption causes cellular injury. Recent developments indicate that ethanol induces epigenetic alterations, particularly acetylation, methylation of histones, and hypo- and hypermethylation of DNA. This has ...Alcohol consumption causes cellular injury. Recent developments indicate that ethanol induces epigenetic alterations, particularly acetylation, methylation of histones, and hypo- and hypermethylation of DNA. This has opened up a new area of interest in ethanol research and is providing novel insight into actions of ethanol at the nucleosomal level in relation to gene expression and patho-physiological consequences. The epigenetic effects are mainly attributable to ethanol metabolic stress (Emess), generated by the oxidative and non-oxidative metabolism of ethanol, and dysregulation of methionine metabolism. Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential.展开更多
African catfish Clarias gariepinus brood stocks were bred by normal induced breeding method, After fertilization, the eggs were treated with 0.40%, 0.50% and 0.60% concentration levels of MS （methylated spirit） and ...African catfish Clarias gariepinus brood stocks were bred by normal induced breeding method, After fertilization, the eggs were treated with 0.40%, 0.50% and 0.60% concentration levels of MS （methylated spirit） and a control treatment without MS （0%）. The objective was to remove the stickiness of the egg outer vitelline membrane to improve hatchability and survival of the hatchlings. Two batches of the treatments were carried out according to treatment duration of 5 s and l0 s. The eggs hatched normally with the highest hatching percentage of 62.31% in eggs treated with 0.40% MS concentration in 5 s treatment and 61.92% in the same concentration for 10 s. The control treatment of 0.00% MS treatment gave the lowest hatchability of 49.69% at 5 s and 45.71% at 10 s exposure time. Growth performance of the hatchlings improved in eggs treated than those not treated. Those treated had higher weight gain and percentage specific growth rates than those not treated. Percentage survival ranged from 75% to 90 % in both treated and untreated groups. MS can therefore be safely used in fish hatchery to prevent egg stickiness to improve hatchability and larval development.展开更多
文摘Alcohol consumption causes cellular injury. Recent developments indicate that ethanol induces epigenetic alterations, particularly acetylation, methylation of histones, and hypo- and hypermethylation of DNA. This has opened up a new area of interest in ethanol research and is providing novel insight into actions of ethanol at the nucleosomal level in relation to gene expression and patho-physiological consequences. The epigenetic effects are mainly attributable to ethanol metabolic stress (Emess), generated by the oxidative and non-oxidative metabolism of ethanol, and dysregulation of methionine metabolism. Epigenetic changes are important in ethanol-induced hepatic steatosis, fibrosis, carcinoma and gastrointestinal injury. This editorial highlights these new advances and its future potential.
文摘African catfish Clarias gariepinus brood stocks were bred by normal induced breeding method, After fertilization, the eggs were treated with 0.40%, 0.50% and 0.60% concentration levels of MS （methylated spirit） and a control treatment without MS （0%）. The objective was to remove the stickiness of the egg outer vitelline membrane to improve hatchability and survival of the hatchlings. Two batches of the treatments were carried out according to treatment duration of 5 s and l0 s. The eggs hatched normally with the highest hatching percentage of 62.31% in eggs treated with 0.40% MS concentration in 5 s treatment and 61.92% in the same concentration for 10 s. The control treatment of 0.00% MS treatment gave the lowest hatchability of 49.69% at 5 s and 45.71% at 10 s exposure time. Growth performance of the hatchlings improved in eggs treated than those not treated. Those treated had higher weight gain and percentage specific growth rates than those not treated. Percentage survival ranged from 75% to 90 % in both treated and untreated groups. MS can therefore be safely used in fish hatchery to prevent egg stickiness to improve hatchability and larval development.
