2013年12月12日，欧洲化妆品个人护理用品协会（Cosmetics Europe，the personal care association）发表了关于停留类化妆品（包括化妆用湿巾）停止使用防腐剂MIT的行业建议，并建议化妆品公司无须等待欧盟化妆品法规1223／2009关于MI...2013年12月12日，欧洲化妆品个人护理用品协会（Cosmetics Europe，the personal care association）发表了关于停留类化妆品（包括化妆用湿巾）停止使用防腐剂MIT的行业建议，并建议化妆品公司无须等待欧盟化妆品法规1223／2009关于MIT使用产品类型的监管更新并尽早在停留类化妆品中停止使用防腐剂MIT。展开更多
Methylchloroisothiazolinone and methylisothiazolinone (MCI/ MI) contact allergy affects 1-3%of patch-tested patients in European centres. The aim of the present study was to evaluate the importance of the factors -tim...Methylchloroisothiazolinone and methylisothiazolinone (MCI/ MI) contact allergy affects 1-3%of patch-tested patients in European centres. The aim of the present study was to evaluate the importance of the factors -time and concentration (dose/per unit area) -in the elicitation capacity by means of a repeated open application test (ROAT) experimental design. The study was designed as a double-blind, placebo-controlled, dose-response ROAT preceded by a diagnostic patch testing. 25 subjects with confirmed MCI/MI allergy and 10 healthy, non-MCI/MI allergic control subjects were exposed to 0.025 μg/cm2 (2 p.p.m.) of MCI/MI/unit area of the skin for 4 weeks. After a wash-out period of at least 4 weeks, the subjects were exposed to 0.094 μg/cm2 (7.5 p.p.m.) of MCI/MI/unit area of the skin for 4 weeks. The study showed the importance of both time and exposure in the elicitation process. It demonstrated that the elicitation threshold for MCI/MI is expected to be in the proximity of 0.025 μg/cm2 although it was not possible to establish a definitive elicitation threshold for MCI/MI in this study.展开更多
文摘2013年12月12日，欧洲化妆品个人护理用品协会（Cosmetics Europe，the personal care association）发表了关于停留类化妆品（包括化妆用湿巾）停止使用防腐剂MIT的行业建议，并建议化妆品公司无须等待欧盟化妆品法规1223／2009关于MIT使用产品类型的监管更新并尽早在停留类化妆品中停止使用防腐剂MIT。
文摘Methylchloroisothiazolinone and methylisothiazolinone (MCI/ MI) contact allergy affects 1-3%of patch-tested patients in European centres. The aim of the present study was to evaluate the importance of the factors -time and concentration (dose/per unit area) -in the elicitation capacity by means of a repeated open application test (ROAT) experimental design. The study was designed as a double-blind, placebo-controlled, dose-response ROAT preceded by a diagnostic patch testing. 25 subjects with confirmed MCI/MI allergy and 10 healthy, non-MCI/MI allergic control subjects were exposed to 0.025 μg/cm2 (2 p.p.m.) of MCI/MI/unit area of the skin for 4 weeks. After a wash-out period of at least 4 weeks, the subjects were exposed to 0.094 μg/cm2 (7.5 p.p.m.) of MCI/MI/unit area of the skin for 4 weeks. The study showed the importance of both time and exposure in the elicitation process. It demonstrated that the elicitation threshold for MCI/MI is expected to be in the proximity of 0.025 μg/cm2 although it was not possible to establish a definitive elicitation threshold for MCI/MI in this study.
