合成了一种新型感光性单体丙烯酸(4 N,N 二甲氨基肉桂酰氧乙基)酯(DMACEA)及其与丙烯酸的共聚物P(DMACEA co AA).用紫外吸收和荧光光谱研究了聚合物溶液的光敏感性,用傅立叶红外光谱研究了聚合物成膜后的光交联性及其过程.结果表明:DMA...合成了一种新型感光性单体丙烯酸(4 N,N 二甲氨基肉桂酰氧乙基)酯(DMACEA)及其与丙烯酸的共聚物P(DMACEA co AA).用紫外吸收和荧光光谱研究了聚合物溶液的光敏感性,用傅立叶红外光谱研究了聚合物成膜后的光交联性及其过程.结果表明:DMACEA具有较好的光敏性,P(DMACEA co AA)具有较好光交联性,交联膜水溶胀和透光性也较好.展开更多
Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However,...Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However, in many cases the nucleoside derivatives have a poor affinity for nucleoside kinases. Nucleoside 5′-phosphorothioates is relatively resistant to enzymatic transformations. In this paper, 2′,3′-O-alkoxymethylidene adenosine 5′-thiophosphoramidates were synthesized through a highly efficient approach. The new compounds were characterized by NMR, IR and ESI-MS.展开更多
文摘合成了一种新型感光性单体丙烯酸(4 N,N 二甲氨基肉桂酰氧乙基)酯(DMACEA)及其与丙烯酸的共聚物P(DMACEA co AA).用紫外吸收和荧光光谱研究了聚合物溶液的光敏感性,用傅立叶红外光谱研究了聚合物成膜后的光交联性及其过程.结果表明:DMACEA具有较好的光敏性,P(DMACEA co AA)具有较好光交联性,交联膜水溶胀和透光性也较好.
文摘Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However, in many cases the nucleoside derivatives have a poor affinity for nucleoside kinases. Nucleoside 5′-phosphorothioates is relatively resistant to enzymatic transformations. In this paper, 2′,3′-O-alkoxymethylidene adenosine 5′-thiophosphoramidates were synthesized through a highly efficient approach. The new compounds were characterized by NMR, IR and ESI-MS.
