儿童促甲状腺素抵抗综合征的临床特点及文献复习

目的:探讨儿童促甲状腺激素抵抗综合征(RTSH)的临床特点。方法:回顾性分析RTSH患儿的临床资料。结果:临床表现甲状腺功能正常的高TSH血症及甲状腺功能低下两种表现型。实验室检查以异常的血清促甲状腺激素水平升高伴或不伴甲状腺激素水平低下为特点。结论:RTSH临床表现主要为无症状或甲低。促甲状腺素受体(TSHR)基因被认为是RTSH的候选基因之一。

表现为肾功能不全的甲状腺功能减退一例

甲状腺功能减退症是由于各种原因引起的低甲状腺素血症或甲状腺素抵抗而引起的全身性低代谢综合征,临床表现多样,但以肾功能异常表现的报道不多见,容易误诊漏诊,我院肝胆腔镜科遇到一例此患者,报道如下.

以肠梗阻为首发表现的甲状腺功能减退症一例

甲状腺功能减退症（hypothyroidism）简称甲减，是由于各种原因导致的低甲状腺激素血症或甲状腺素抵抗而引起的全身性低代谢综合征。甲减起病较隐匿，可累及全身多个系统，病程缓慢，临床表现缺乏特异性，易漏诊误诊。肠梗阻是甲减罕见的胃肠道并发症，尤其是以肠梗阻为首发表现的甲减患者，早期临床诊断非常困难。本文回顾性分析1例以肠梗阻为首发表现的甲状腺功能减退症患者的临床资料，并结合国内外文献进行讨论。

Biochemical Changes in Chronic Renal Failure Pre and Post Hemodialysis

The aim of the study was to evaluate Paraoxonase-I （PON-1）, resistin and bone mineral markers （Parathyroid Hormone （PTH）, Ca＋＋ and P） levels as biochemical marker for patients with Chronicrenal Failure （CRF）. The sample of this study consists of 100 patients and 100 apparently healthy individuals. All patients were those who were receiving Hemodialysis （HD） therapy in the dialysis unit in Kirkuk general. The levels of PON-1, Ca＋＋ were significantly lower in CRF patients pre HD when compared with healthy controls, and significantly increased in post HD as compared to pre HD, but still lower than normal controls. Serum P, resistin and PTH levels were significantly higher in CRF patients pre HD process when compared with healthy controls, and their levels were significantly decreased after HD as compared to pre HD, but remained higher than controls. PON-1 was negatively correlated with the resistin, Blood Urea （BU）, Creatinine （Cr）, PTH, but positively correlated with Ca＋＋. PON-I activity was significantly decreased in CRF patients before HD and increased after HD, but remained lower than controls. PON-1 was negatively correlated with the Body Max Index （MBI）, resistin, BU, Cr, PTH, but significantly and positively correlated with Ca＋＋.