近年来,医学界越来越多地将高电位疗法应用于理疗领域,发挥对人体医疗保健及治疗疾病的作用。本实验根据临床高电位治疗仪的工作原理,设计了两种不同类型的高压电场(high voltage electric field,HVEF),通过对持续12周的高压电场暴露Wis...近年来,医学界越来越多地将高电位疗法应用于理疗领域,发挥对人体医疗保健及治疗疾病的作用。本实验根据临床高电位治疗仪的工作原理,设计了两种不同类型的高压电场(high voltage electric field,HVEF),通过对持续12周的高压电场暴露Wistar大鼠的一般临床症状和外周静脉血血细胞的数量、形态和白细胞分类等参数动态观察,以深入探讨这两种高压电场对血液学生理指标的影响及其长期应用的安全性。结果表明,实验第6周和第12周时各处理组与对照组比较,雌雄大鼠的血液学生理指标均无显著性差异(P>0.05),高压电场对大鼠外周血血常规无明显影响。展开更多
Objective: To observe the influence of electrolytic destruction of nucleus soli tary tract (NTS) and hypothalamic paraventricular nucleus (PVN) on the effect of electroacupuncture (EA) in improving ischemic myocardia ...Objective: To observe the influence of electrolytic destruction of nucleus soli tary tract (NTS) and hypothalamic paraventricular nucleus (PVN) on the effect of electroacupuncture (EA) in improving ischemic myocardia cellular transmembrane action potential (TMAP). Methods: 38 Japanese breed big-ear wh ite rabbits (ane sthetized with 20% Urethane, 4 mL/kg) were randomly divided into acute myocardia l ischemia (AMI) group (n=8), PVN destruction group ( n=12) and PVN+NTS destructio n group (n=18). AMI model was established by occlusion of the descending anterio r branch (DAB) of the coronary artery. TMAP of myocytes was recorded by using a glass microelectrode which was fixed to a suspending spring silver wire. Bilater al "Neiguan"(PC 6) in all the 3 groups were punctured and stimulated electri call y by using parameters of continuous waves, frequency of 7 Hz, intensity of 6 mA a nd duration of 30 minutes. Results: After AMI, ECG-ST elevated significantly whil e APA lowered, APD50 and APD90 shortened clearly in comparison with those of pre -AMI in the 3 groups. Compared with AMI group, ECG-ST values of PVN destructi on group and PVN+NTS destruction group were significantly higher (P <0.05~0.01), whi le APA, APD50 and APD90 all significantly lower in all the recording time course s(P<0.05). The facts displayed that electrolytic destru ction of PVN and PVN+NT S could produce ischemic myocardial injury and reduce the protective effect of E A on ischemic myocardial cells. Comparison between PVN destruction and PVN+NTS g roups showed that all the 4 indexes of the later group were evidently worse than those of the former group (P<0.05), suggesting after des truction of these two n uclei, the effect of EA was worsened further. Conclusion: Electrolytic destru ction of PVN and NTS weakens the protective effect of EA on ischemic myocardial cells, both NTS and PVN take part in the effect of EA of "Neiguan"(PC 6) Point i n improving ischemic myocardium.展开更多
Objective: To observe the segmental distribution of afferent Electroacupuncture (EA) signals from acupoints of the Pericardium (PC) Meridian and try to analyze the relative specificity of running route of PC Meridian....Objective: To observe the segmental distribution of afferent Electroacupuncture (EA) signals from acupoints of the Pericardium (PC) Meridian and try to analyze the relative specificity of running route of PC Meridian.Methods: A total of 85 Wistar rats anesthetized with mixed solution of Chloralose (5 mg/100 g) and Urethane (42 mg/100g) were used in this study. Under microscopic observation, the micro-filaments of the distal end of the dorsal root were carefully separated after tearing the spinal pia mater to attach to a recording electrode. The reference electrode was placed beneath the skin of the incision. Two caudal and two rostral dorsal roots near the recorded one were cut off separately. Electrical activity of the isolated micro-filaments was observed before and after EA of "Daling" (PC 7) -"Jianshi" (PC 5), "Quze" (PC 3) of PC Meridian, "Yangchi"(TE 4)- "Zhigou" (TE 6), "Tianjing" (TE 10)-" Qin-glengyuan" (TE 11) of the Triple Energizer (TE) Meridian with electric current 1 mA and 2 mA and double pulses. Results: ① After EA (1 mA) of "Daling"(PC 7)-"Jianshi"(PC 5), the firing rates of 3 out of 10 (33.3%) micro-filaments in C5 segment, 5 out of 10 (50.0%) in C6, 7 out of 10 (70.0%) in 07, 3 out of 10 (30.0%) in C8 and 3 out of 13 (23. 1%) in T1 increased considerably;and after EA of "Quze" (PC 3), those of 3/10 of C5, 4/10 of C6, 6/10 of C7, 3/10 of C8, and 3/10 of T1 increased significantly. ② After EA (1 mA) of "Yangchi"(TE 4)- "Zhigou" (TE 6) and "Tianjing" (TE 10)- "Qinglengyuan" (TE 11). the firing rates of 2/10, 2/10 of micro-filaments In C5, 7/10, 3/10 of C6, 5/10 and 4/10 of C7, 1/10 and 1/10 of C8, and 2/13 and 1/10 of T1 increased significantly. It indicates that C7 dorsal root may play the first important role in conveying EA signals from PC Meridian acupoints to the spinal cord, while C6 and C7 may be mainly responsible for conveying EA signals from TE Meridian acupoints to the spinal cord. Conclusion: The peripheral afferent pathway for transmitting EA signals from PC Meridian acupoints probably has a relative specificity.展开更多
Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impair...Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital.Thirty-six MCI patients were randomly distributed into two groups.One group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social activities.The amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week follow-up.Results:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks follow-up.Also,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp group.However,there was no difference in P300 amplitude in either brain area between the two groups.Conclusion:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.展开更多
Literatures on pain intervention with transcutaneous electrical acupoint stimulation(TEAS)were collected by searching the databases both in Chinese and English,and summarized to understand the research progress of TEA...Literatures on pain intervention with transcutaneous electrical acupoint stimulation(TEAS)were collected by searching the databases both in Chinese and English,and summarized to understand the research progress of TEAS effects on pain mediators in recent years.This will provide a more objective and scientific theoretical basis for clinical practice of TEAS to treat pain syndrome,thus promoting the clinical application of TEAS.Our literature analysis indicated that TEAS effectively regulated the release levels of various pain factors such as prostaglandin,5-hydroxytryptamine,interleukins,substance P and tumor necrosis factor-αto achieve the analgesic effects by affecting the conduction pathways.TEAS is a safe,non-invasive and effective treatment for pain syndrome.However,further research is necessary due to the lack of rigor of the current clinical trial design.展开更多
Objective: To compare the therapeutic efficacy between warm needling moxibustion and electroacupuncture (EA) in the treatment of simple obesity due to yang deficiency of the spleen and kidney. Methods: Seventy patient...Objective: To compare the therapeutic efficacy between warm needling moxibustion and electroacupuncture (EA) in the treatment of simple obesity due to yang deficiency of the spleen and kidney. Methods: Seventy patients with simple obesity due to yang deficiency of the spleen and kidney were randomly divided into a warm needling moxibustion group and an EA group, with 35 subjects in each group. Same major acupoints were selected for the two groups, including Shuifen (CV 9), Guanyuan (CV 4), Daheng (SP 15), Shuidao (ST 28), Shousanli (LI 10), Zusanli (ST 36), Sanyinjiao (SP 6) and Taixi (KI 3). The warm needling moxibustion group received warm needling moxibustion, while the EA group received EA treatment. The interventions were performed once every other day, with 15 treatments as one course. The therapeutic efficacy, body weight and body mass index (BMI) were then observed and compared. Results: The total effective rate in the warm needling moxibustion group was 85.7% versus 77.1% in the EA group, and the between-group difference was statistically significant (P<0.05). The warm needling moxibustion was remarkably superior to the EA in weight loss and lowering BMI, both with statistical significance (P<0.05, P<0.01). At the three-month follow-up, the body weight and BMI further decreased in the warm needling moxibustion group (both P<0.05), and the levels were lower than those in the EA group (P<0.05, P<0.01). Conclusion: Warm needling moxibustion can produce reliable and consistent efficacy in the treatment of simple obesity due to yang deficiency of the spleen and kidney. Compared with EA, warm needling moxibustion shows advantage in both short-term and long-term efficacies, and thus is worth promotion in clinical practice.展开更多
Objective: To make objective evaluation on treatment of lumbar intervertebral disc herniation with electric acupuncture. Method: All 200 cases were randomly allocated into an observation group (100 cases) and a co...Objective: To make objective evaluation on treatment of lumbar intervertebral disc herniation with electric acupuncture. Method: All 200 cases were randomly allocated into an observation group (100 cases) and a control group (100 cases). Cases in the observation group were treated with electric acupuncture. Cases in the control group were treated with oral administration of Mobic. Result: The total effective rate in the observation group was 86.5%, and the total effective rate of the control group was 75.0%. There was a significant difference between the two groups (P〈0.01). Conclusion: Electric acupuncture is a safe and remarkably effective way for lumbar intervertebral disc herniation.展开更多
The incidence rate of polycystic ovary syndrome (PCOS) is about 5%-10% in the women of childbearing age and accounts for 30%-60% in the patients with anovulatory infertility. From 2005 to 2008, I treated 20 cases of...The incidence rate of polycystic ovary syndrome (PCOS) is about 5%-10% in the women of childbearing age and accounts for 30%-60% in the patients with anovulatory infertility. From 2005 to 2008, I treated 20 cases of polycystic ovary infertility by acupuncture-moxibustion plus acupressure along the meridians. Now, the report is given as follows.展开更多
Objective:To observe the clinical effects of electroacupuncture (EA) plus acuoint-injection for nerve root sciatica. 〈br〉 Methods:A total of 114 cases were randomly divided into an observation group and a contro...Objective:To observe the clinical effects of electroacupuncture (EA) plus acuoint-injection for nerve root sciatica. 〈br〉 Methods:A total of 114 cases were randomly divided into an observation group and a control group, 57 cases in each group. The observation group was given EA plus acupoint-injection therapy with Cobamamide. The control group was given oral administration of Diclofenac Sodium Sustained-release Tablets plus muscular injection of Cobamamide. After one-course treatment, the clinical effects were compared between the two groups. 〈br〉 Results:The total effective rate was 96.5%in the observation group and 91.2%in the control group, without a statistical significance in the difference between the two groups (P〉0.05). The curative rate was 57.9%in the observation group and 21.1% in the control group, with a statistical significance in the difference between the two groups (P〈0.05). In the follow-up on the fourth day after the treatment, the recurrence rate was 23.1%in the observation group and 47.9%in the control group, with statistical difference between the two groups (P〈0.05). 〈br〉 Conclusion: EA plus acupoint-injection therapy for sciatica of nerve roots is remarkable in the clinical effect and needs promotion in clinic.展开更多
Objective To examine the effect of acupuncture-like transcutaneous electrical nerve stimulation(ACUTENS)on labor pain in nulliparous women.Methods This randomized clinical trial was conducted at Razi Hospital in Qazvi...Objective To examine the effect of acupuncture-like transcutaneous electrical nerve stimulation(ACUTENS)on labor pain in nulliparous women.Methods This randomized clinical trial was conducted at Razi Hospital in Qazvin,Iran between January and July 2018.After the screening process,144 out of 184 pregnant women were selected by convenience sampling and assigned to an intervention group or a control group by the block randomization method.The intervention group received ACUTENS at Hegu(LI4),Shenmen(HT7),Sanyinjiao(SP6),and Neimadian(Extra)during various stages of delivery in addition to routine labor care at the delivery room.For the control group,the same routine labor care was performed alone.The severity of pain was assessed in the two groups using the visual analog scale(VAS).The data were analyzed using R software(ver.4.0.2)and repeated measurement analysis of variance.Results ACUTENS reduced the mean score of pain intensity in the first stage of labor in the intervention group more than that in the control group(P<0.001).Also,the mean scores of pain intensity in the second stage of labor,episiotomy,and one hour after delivery in the intervention group were significantly lower than those in the control group(P<0.001).Conclusion ACUTENS at Hegu(LI4),Shenmen(HT7),Sanyinjiao(SP6),and Neimadian(Extra)can decrease the intensity of labor pain in nulliparous women.It can be used as a non-pharmacological method for reducing pain in and after labor.展开更多
Objective: To observe the effect of electroacupuncture(EA) on the electrogastrogram and gastric antrum ghrelin in rats with diabetic gastroparesis(DGP).Methods: Fifty Sprague-Dawley(SD) rats were randomly divi...Objective: To observe the effect of electroacupuncture(EA) on the electrogastrogram and gastric antrum ghrelin in rats with diabetic gastroparesis(DGP).Methods: Fifty Sprague-Dawley(SD) rats were randomly divided into group A, group B, group C, group D and group E,10 rats in each group. Group A was the blank control group without intervention. Group B, Group C, Group D and Group E were treated with single dose intraperitoneal injection of 2% streptozotocin(STZ), combined with 8-week high glucose and high fat diet to establish DGP rat models. Group B was the model group without treatment. Group C was the EA at acupoint group, was treated with EA at Zusanli(ST 36), Liangmen(ST 21) and Sanyinjiao(SP 6). Group D was the EA at non-acupoint group, was treated by EA at the control points of Zusanli(ST 36), Liangmen(ST 21) and Sanyinjiao(SP 6). Rats in the metoclopramide control group received 1.7% metoclopramide solution [10 mL/(kg·bw)] by gavage. Rat's blood glucose level was measured by blood glucose meter; gastric emptying rate was detected using phenol red as a marker; the electrogastrogram was detected by BL-420 F biological function system; the protein level of ghrelin was detected by enzyme-linked immunosorbent assay(ELISA); the expression of ghrelin mRNA was detected by real-time polymerase chain reaction(RT-PCR).Results: Compared with group A, the blood glucose of group B, C, D and E were significantly increased before and after the treatment(all P〈0.01); after treatment, the gastric emptying rate of group B was significantly decreased(P〈0.01),the migration rates of small intestine in group B, C, D and E were significantly lower(all P〈0.01), and the protein content of ghrelin in group C was significantly decreased(P〈0.01); the expressions of ghrelin mRNA were significantly increased in group B, C, D and E(all P〈0.01), the mean amplitudes of electrogastrogram in group B and D were significantly decreased(both P〈0.01). After treatment, compared with group B, the blood glucose of group C was significantly decreased(P〈0.05), the gastric emptying rate and small intestine migration rate were significantly increased in group C and E(P〈0.05, P〈0.01), the small intestinal migration rate was significantly increased in group D(P〈0.05), the expression of ghrelin in protein and mRNA in group C was significantly lower(P〈0.01), the expression of ghrelin mRNA in group E was significantly lower(P〈0.05), and the mean amplitude of electrogastrogram in group C was significantly increased(P〈0.05). After treatment, compared with group D, the protein and mRNA expressions of ghrelin in group C were significantly decreased(P〈0.01). After treatment, compared with group E, the protein expression of ghrelin in group C was significantly decreased(P〈0.01).Conclusion: EA at Zusanli(ST 36), Liangmen(ST 21) and Sanyinjiao(SP 6) could regulate the blood glucose level of DGP model rats, enhance electrogastrogram activity, promote gastric emptying, and regulate ghrelin expression in protein and mRNA.展开更多
Objective: To observe the clinical effect of treating lumbar intervertebral disc protrusion by needling the points on both sides of the impaired lumbar vertebrae. Methods: One hundred and eighty cases of lumbar inte...Objective: To observe the clinical effect of treating lumbar intervertebral disc protrusion by needling the points on both sides of the impaired lumbar vertebrae. Methods: One hundred and eighty cases of lumbar intervertebral disc protrusion were randomly divided into three groups, treatment group, control group of acupuncture and control group of western medicine, with 60 cases in each group. The therapeutic effects were compared after 20-day treatments. Result: The effective rate was 96.7% in the treatment group, 80.0% in the acupuncture group, and 81.7% in the Western medicine group. There was a statistically significant difference between the treatment group and two control groups (P〈0.05). Conclusion: It is an effective therapy to treat lumbar intervertebral disc protrusion by puncturing the acupuncture points on both sides of the impaired lumbar vertebrae.展开更多
Objective:To observe the clinical effects of half puncture plus transcutaneous acupoint electric stimulation in the treatment of infantile facial paralysis. Methods:A total of 60 patients with infantile facial paral...Objective:To observe the clinical effects of half puncture plus transcutaneous acupoint electric stimulation in the treatment of infantile facial paralysis. Methods:A total of 60 patients with infantile facial paralysis were divided into a treatment group and a control group by the random digital table, 30 cases in each group. The treatment group was treated with half puncture plus transcutaneous acupoint electric stimulation. The control group was treated with routine acupuncture. Before and after treatment, House-Brackmann (H-B) grading was used to evaluate the sick children respectively. The total effective rates were compared between the two groups after treatment. Results:After 6-course treatments, the total effective rate was 96.5% in the treatment group and 80.0% in the control group, there was a statistical difference between the two groups (P〈0.05) in comparison of the total effective rate. After 6-course treatments, H-B scores were all elevated than those before treatment in the two groups (P〈0.05); there was a statistical difference between the two groups (P〈0.05). Conclusion:Half puncture plus transcutaneous acupoint electric stimulation is better than routine acupuncture in curative effect for infantile facial paralysis.展开更多
Objective:To observe the clinical efficacy of electroacupuncture (EA) combined with iontophoresis of Chinese medicine for lumbar intervertebral disc herniation (LIDH). Methods: A total of 80 LIDH cases were rand...Objective:To observe the clinical efficacy of electroacupuncture (EA) combined with iontophoresis of Chinese medicine for lumbar intervertebral disc herniation (LIDH). Methods: A total of 80 LIDH cases were randomly allocated into a treatment group and a control group by the random number table, 40 in each group. Cases in the treatment group were treated with EA combined with iontophoresis of Chinese medicine, whereas cases in the control group were treated with EA alone. Cases in both groups were treated once a day, 10 times for one course and there was a 3-day interval between two courses. The therapeutic efficacies in two groups were assessed after two courses of treatment. The short-form McGill pain questionnaire (SF-MPQ) and Japanese Orthopedic Association (JOA) low back pain evaluation questionnaire were used for the scoring system before treatment, after the first treatment and 2 courses of treatment. Results: After two courses of treatment, the total effective rate was 95.0% in the treatment group, versus 87.5% in the control group, showing a statistical difference (P〈0.05). The therapeutic efficacy in the treatment group was significantly better than that in the control group after the first treatment and 2 courses of treatment. The score of SF-MPQ in the treatment group was more significantly decreased and the JOA score in the treatment group was more significantly increased, showing statistical differences (P〈0.01). Conclusion: EA at Jiaji (EX-B2) points combined with iontophoresis of Chinese medicine is better than EA alone in alleviating low back and leg pain and improving functions of the low back and leg as well as the quality of life of LIDH patients .展开更多
Objective:To explore the therapeutic efficacy and mechanism of transcutaneous electrical acupoint stimulation(TEAS)for menopausal insomnia.Methods:A total of 80 patients with menopausal insomnia were randomly divided ...Objective:To explore the therapeutic efficacy and mechanism of transcutaneous electrical acupoint stimulation(TEAS)for menopausal insomnia.Methods:A total of 80 patients with menopausal insomnia were randomly divided into a control group and an observation group,with 40 cases in each group.The patients in the control group received conventional Western medication treatment,and the patients in the observation group received TEAS on the basis of conventional Western medication treatment.The treatment for both groups lasted for 4 weeks.Before and after treatment,Pittsburgh sleep quality index(PSQI)and modified Kupperman scale were evaluated,and the serum levels of estradiol(E2)and follicular stimulating hormone(FSH)were measured.The therapeutic efficacy was evaluated after treatment.Results:After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);in the control group,the improvement of PSQI score was significant(P<0.05),while the change of modified Kupperman score was insignificant(P>0.05);the PSQI and Kupperman scores in the observation group were significantly improved after treatment(both P<0.05),and there were significant differences between the observation group and the control group in PSQI and Kupperman scores(both P<0.05).After treatment,the serum E2 and FSH levels in the control group were not statistically different from those before treatment(both P>0.05);the serum E2 level was significantly increased(P<0.05),and the FSH level was decreased(P<0.05)in the observation group after treatment,and the between-group differences in serum levels of E2 and FSH were significant(both P<0.05).Conclusion:TEAS plus conventional Western medication in treating menopausal insomnia is effective,and can significantly improve the symptoms of insomnia and menopause,which may be related to the regulation of serum E2 and FSH levels.展开更多
文摘近年来,医学界越来越多地将高电位疗法应用于理疗领域,发挥对人体医疗保健及治疗疾病的作用。本实验根据临床高电位治疗仪的工作原理,设计了两种不同类型的高压电场(high voltage electric field,HVEF),通过对持续12周的高压电场暴露Wistar大鼠的一般临床症状和外周静脉血血细胞的数量、形态和白细胞分类等参数动态观察,以深入探讨这两种高压电场对血液学生理指标的影响及其长期应用的安全性。结果表明,实验第6周和第12周时各处理组与对照组比较,雌雄大鼠的血液学生理指标均无显著性差异(P>0.05),高压电场对大鼠外周血血常规无明显影响。
基金This studyis subsidized by National Science Foundation of China (No .30171179) .
文摘Objective: To observe the influence of electrolytic destruction of nucleus soli tary tract (NTS) and hypothalamic paraventricular nucleus (PVN) on the effect of electroacupuncture (EA) in improving ischemic myocardia cellular transmembrane action potential (TMAP). Methods: 38 Japanese breed big-ear wh ite rabbits (ane sthetized with 20% Urethane, 4 mL/kg) were randomly divided into acute myocardia l ischemia (AMI) group (n=8), PVN destruction group ( n=12) and PVN+NTS destructio n group (n=18). AMI model was established by occlusion of the descending anterio r branch (DAB) of the coronary artery. TMAP of myocytes was recorded by using a glass microelectrode which was fixed to a suspending spring silver wire. Bilater al "Neiguan"(PC 6) in all the 3 groups were punctured and stimulated electri call y by using parameters of continuous waves, frequency of 7 Hz, intensity of 6 mA a nd duration of 30 minutes. Results: After AMI, ECG-ST elevated significantly whil e APA lowered, APD50 and APD90 shortened clearly in comparison with those of pre -AMI in the 3 groups. Compared with AMI group, ECG-ST values of PVN destructi on group and PVN+NTS destruction group were significantly higher (P <0.05~0.01), whi le APA, APD50 and APD90 all significantly lower in all the recording time course s(P<0.05). The facts displayed that electrolytic destru ction of PVN and PVN+NT S could produce ischemic myocardial injury and reduce the protective effect of E A on ischemic myocardial cells. Comparison between PVN destruction and PVN+NTS g roups showed that all the 4 indexes of the later group were evidently worse than those of the former group (P<0.05), suggesting after des truction of these two n uclei, the effect of EA was worsened further. Conclusion: Electrolytic destru ction of PVN and NTS weakens the protective effect of EA on ischemic myocardial cells, both NTS and PVN take part in the effect of EA of "Neiguan"(PC 6) Point i n improving ischemic myocardium.
文摘Objective: To observe the segmental distribution of afferent Electroacupuncture (EA) signals from acupoints of the Pericardium (PC) Meridian and try to analyze the relative specificity of running route of PC Meridian.Methods: A total of 85 Wistar rats anesthetized with mixed solution of Chloralose (5 mg/100 g) and Urethane (42 mg/100g) were used in this study. Under microscopic observation, the micro-filaments of the distal end of the dorsal root were carefully separated after tearing the spinal pia mater to attach to a recording electrode. The reference electrode was placed beneath the skin of the incision. Two caudal and two rostral dorsal roots near the recorded one were cut off separately. Electrical activity of the isolated micro-filaments was observed before and after EA of "Daling" (PC 7) -"Jianshi" (PC 5), "Quze" (PC 3) of PC Meridian, "Yangchi"(TE 4)- "Zhigou" (TE 6), "Tianjing" (TE 10)-" Qin-glengyuan" (TE 11) of the Triple Energizer (TE) Meridian with electric current 1 mA and 2 mA and double pulses. Results: ① After EA (1 mA) of "Daling"(PC 7)-"Jianshi"(PC 5), the firing rates of 3 out of 10 (33.3%) micro-filaments in C5 segment, 5 out of 10 (50.0%) in C6, 7 out of 10 (70.0%) in 07, 3 out of 10 (30.0%) in C8 and 3 out of 13 (23. 1%) in T1 increased considerably;and after EA of "Quze" (PC 3), those of 3/10 of C5, 4/10 of C6, 6/10 of C7, 3/10 of C8, and 3/10 of T1 increased significantly. ② After EA (1 mA) of "Yangchi"(TE 4)- "Zhigou" (TE 6) and "Tianjing" (TE 10)- "Qinglengyuan" (TE 11). the firing rates of 2/10, 2/10 of micro-filaments In C5, 7/10, 3/10 of C6, 5/10 and 4/10 of C7, 1/10 and 1/10 of C8, and 2/13 and 1/10 of T1 increased significantly. It indicates that C7 dorsal root may play the first important role in conveying EA signals from PC Meridian acupoints to the spinal cord, while C6 and C7 may be mainly responsible for conveying EA signals from TE Meridian acupoints to the spinal cord. Conclusion: The peripheral afferent pathway for transmitting EA signals from PC Meridian acupoints probably has a relative specificity.
基金supported by the Youth research project of Fujian Provincial Health Commission(No.2018-1-75)Joint Fund of Fujian Province Scientific and Technological Department(No.2018Y9102)+1 种基金Soft Science Project of Fujian Science and Technology Department(No.2019R0055)National Science Foundation of China(No.81571379).
文摘Objectives:This study aimed to evaluate the effects of a 16-week creative expression intervention program(CrExp)on the event-related potential(ERP)and task reaction time in older individuals with mild cognitive impairment(MCI).Methods:This study is a randomized controlled clinical trial conducted in the Memory Center of Fujian Provincial hospital.Thirty-six MCI patients were randomly distributed into two groups.One group underwent a 16-week creative expression program(CrExp,n=18)and the other performed as a control group(CG,n=18)by general social activities.The amplitude and latency of ERP-P300 from the central(Cz),parietal(Pz),frontal(Fz)cortices and task reaction time(RT)were assessed at baseline,postinterventi on,and 24-week follow-up.Results:The CrExp group showed greater differences than CG of P300 latency in Cz(F=4.37,P=0.015),Pz(F=2.78,P=0.009),Fz(F=6.45,P=0.031)brain area after 16 weeks of intervention and in Fz(F=3.23,P=0.028),Cz(F=3.79,P=0.024),and Pz(F=5.60,P=0.036)at 24 weeks follow-up.Also,we analyzed the task reaction time between two groups and found that a shorten reaction time at postintervention(F=4.47,P=0.011)and 24 weeks follow-up(F=3.12,P=0.007)in the CrExp group.However,there was no difference in P300 amplitude in either brain area between the two groups.Conclusion:The electrophysiological results of the creative expression cognitive therapy group were more obvious than those of the general cognitive therapy group,and the latency and task reaction time may be considered as supported parameters in diagnosing the effects during non-drug therapy intervention in clinical practice.
文摘Literatures on pain intervention with transcutaneous electrical acupoint stimulation(TEAS)were collected by searching the databases both in Chinese and English,and summarized to understand the research progress of TEAS effects on pain mediators in recent years.This will provide a more objective and scientific theoretical basis for clinical practice of TEAS to treat pain syndrome,thus promoting the clinical application of TEAS.Our literature analysis indicated that TEAS effectively regulated the release levels of various pain factors such as prostaglandin,5-hydroxytryptamine,interleukins,substance P and tumor necrosis factor-αto achieve the analgesic effects by affecting the conduction pathways.TEAS is a safe,non-invasive and effective treatment for pain syndrome.However,further research is necessary due to the lack of rigor of the current clinical trial design.
文摘Objective: To compare the therapeutic efficacy between warm needling moxibustion and electroacupuncture (EA) in the treatment of simple obesity due to yang deficiency of the spleen and kidney. Methods: Seventy patients with simple obesity due to yang deficiency of the spleen and kidney were randomly divided into a warm needling moxibustion group and an EA group, with 35 subjects in each group. Same major acupoints were selected for the two groups, including Shuifen (CV 9), Guanyuan (CV 4), Daheng (SP 15), Shuidao (ST 28), Shousanli (LI 10), Zusanli (ST 36), Sanyinjiao (SP 6) and Taixi (KI 3). The warm needling moxibustion group received warm needling moxibustion, while the EA group received EA treatment. The interventions were performed once every other day, with 15 treatments as one course. The therapeutic efficacy, body weight and body mass index (BMI) were then observed and compared. Results: The total effective rate in the warm needling moxibustion group was 85.7% versus 77.1% in the EA group, and the between-group difference was statistically significant (P<0.05). The warm needling moxibustion was remarkably superior to the EA in weight loss and lowering BMI, both with statistical significance (P<0.05, P<0.01). At the three-month follow-up, the body weight and BMI further decreased in the warm needling moxibustion group (both P<0.05), and the levels were lower than those in the EA group (P<0.05, P<0.01). Conclusion: Warm needling moxibustion can produce reliable and consistent efficacy in the treatment of simple obesity due to yang deficiency of the spleen and kidney. Compared with EA, warm needling moxibustion shows advantage in both short-term and long-term efficacies, and thus is worth promotion in clinical practice.
文摘Objective: To make objective evaluation on treatment of lumbar intervertebral disc herniation with electric acupuncture. Method: All 200 cases were randomly allocated into an observation group (100 cases) and a control group (100 cases). Cases in the observation group were treated with electric acupuncture. Cases in the control group were treated with oral administration of Mobic. Result: The total effective rate in the observation group was 86.5%, and the total effective rate of the control group was 75.0%. There was a significant difference between the two groups (P〈0.01). Conclusion: Electric acupuncture is a safe and remarkably effective way for lumbar intervertebral disc herniation.
基金supported by No.1 Hospital Affiliated to Yunnan College of Traditional Chinese Medicine
文摘The incidence rate of polycystic ovary syndrome (PCOS) is about 5%-10% in the women of childbearing age and accounts for 30%-60% in the patients with anovulatory infertility. From 2005 to 2008, I treated 20 cases of polycystic ovary infertility by acupuncture-moxibustion plus acupressure along the meridians. Now, the report is given as follows.
基金supported by the Special Fund for Key Special Clinic from State Administration of Traditional Chinese Medicine
文摘Objective:To observe the clinical effects of electroacupuncture (EA) plus acuoint-injection for nerve root sciatica. 〈br〉 Methods:A total of 114 cases were randomly divided into an observation group and a control group, 57 cases in each group. The observation group was given EA plus acupoint-injection therapy with Cobamamide. The control group was given oral administration of Diclofenac Sodium Sustained-release Tablets plus muscular injection of Cobamamide. After one-course treatment, the clinical effects were compared between the two groups. 〈br〉 Results:The total effective rate was 96.5%in the observation group and 91.2%in the control group, without a statistical significance in the difference between the two groups (P〉0.05). The curative rate was 57.9%in the observation group and 21.1% in the control group, with a statistical significance in the difference between the two groups (P〈0.05). In the follow-up on the fourth day after the treatment, the recurrence rate was 23.1%in the observation group and 47.9%in the control group, with statistical difference between the two groups (P〈0.05). 〈br〉 Conclusion: EA plus acupoint-injection therapy for sciatica of nerve roots is remarkable in the clinical effect and needs promotion in clinic.
文摘Objective To examine the effect of acupuncture-like transcutaneous electrical nerve stimulation(ACUTENS)on labor pain in nulliparous women.Methods This randomized clinical trial was conducted at Razi Hospital in Qazvin,Iran between January and July 2018.After the screening process,144 out of 184 pregnant women were selected by convenience sampling and assigned to an intervention group or a control group by the block randomization method.The intervention group received ACUTENS at Hegu(LI4),Shenmen(HT7),Sanyinjiao(SP6),and Neimadian(Extra)during various stages of delivery in addition to routine labor care at the delivery room.For the control group,the same routine labor care was performed alone.The severity of pain was assessed in the two groups using the visual analog scale(VAS).The data were analyzed using R software(ver.4.0.2)and repeated measurement analysis of variance.Results ACUTENS reduced the mean score of pain intensity in the first stage of labor in the intervention group more than that in the control group(P<0.001).Also,the mean scores of pain intensity in the second stage of labor,episiotomy,and one hour after delivery in the intervention group were significantly lower than those in the control group(P<0.001).Conclusion ACUTENS at Hegu(LI4),Shenmen(HT7),Sanyinjiao(SP6),and Neimadian(Extra)can decrease the intensity of labor pain in nulliparous women.It can be used as a non-pharmacological method for reducing pain in and after labor.
基金supported by National Natural Science Foundation of China,No.81403487National Basic Research Program of China,No.2014CB543102Youth Fund of Hunan Province Education Office,No.14B128~~
文摘Objective: To observe the effect of electroacupuncture(EA) on the electrogastrogram and gastric antrum ghrelin in rats with diabetic gastroparesis(DGP).Methods: Fifty Sprague-Dawley(SD) rats were randomly divided into group A, group B, group C, group D and group E,10 rats in each group. Group A was the blank control group without intervention. Group B, Group C, Group D and Group E were treated with single dose intraperitoneal injection of 2% streptozotocin(STZ), combined with 8-week high glucose and high fat diet to establish DGP rat models. Group B was the model group without treatment. Group C was the EA at acupoint group, was treated with EA at Zusanli(ST 36), Liangmen(ST 21) and Sanyinjiao(SP 6). Group D was the EA at non-acupoint group, was treated by EA at the control points of Zusanli(ST 36), Liangmen(ST 21) and Sanyinjiao(SP 6). Rats in the metoclopramide control group received 1.7% metoclopramide solution [10 mL/(kg·bw)] by gavage. Rat's blood glucose level was measured by blood glucose meter; gastric emptying rate was detected using phenol red as a marker; the electrogastrogram was detected by BL-420 F biological function system; the protein level of ghrelin was detected by enzyme-linked immunosorbent assay(ELISA); the expression of ghrelin mRNA was detected by real-time polymerase chain reaction(RT-PCR).Results: Compared with group A, the blood glucose of group B, C, D and E were significantly increased before and after the treatment(all P〈0.01); after treatment, the gastric emptying rate of group B was significantly decreased(P〈0.01),the migration rates of small intestine in group B, C, D and E were significantly lower(all P〈0.01), and the protein content of ghrelin in group C was significantly decreased(P〈0.01); the expressions of ghrelin mRNA were significantly increased in group B, C, D and E(all P〈0.01), the mean amplitudes of electrogastrogram in group B and D were significantly decreased(both P〈0.01). After treatment, compared with group B, the blood glucose of group C was significantly decreased(P〈0.05), the gastric emptying rate and small intestine migration rate were significantly increased in group C and E(P〈0.05, P〈0.01), the small intestinal migration rate was significantly increased in group D(P〈0.05), the expression of ghrelin in protein and mRNA in group C was significantly lower(P〈0.01), the expression of ghrelin mRNA in group E was significantly lower(P〈0.05), and the mean amplitude of electrogastrogram in group C was significantly increased(P〈0.05). After treatment, compared with group D, the protein and mRNA expressions of ghrelin in group C were significantly decreased(P〈0.01). After treatment, compared with group E, the protein expression of ghrelin in group C was significantly decreased(P〈0.01).Conclusion: EA at Zusanli(ST 36), Liangmen(ST 21) and Sanyinjiao(SP 6) could regulate the blood glucose level of DGP model rats, enhance electrogastrogram activity, promote gastric emptying, and regulate ghrelin expression in protein and mRNA.
文摘Objective: To observe the clinical effect of treating lumbar intervertebral disc protrusion by needling the points on both sides of the impaired lumbar vertebrae. Methods: One hundred and eighty cases of lumbar intervertebral disc protrusion were randomly divided into three groups, treatment group, control group of acupuncture and control group of western medicine, with 60 cases in each group. The therapeutic effects were compared after 20-day treatments. Result: The effective rate was 96.7% in the treatment group, 80.0% in the acupuncture group, and 81.7% in the Western medicine group. There was a statistically significant difference between the treatment group and two control groups (P〈0.05). Conclusion: It is an effective therapy to treat lumbar intervertebral disc protrusion by puncturing the acupuncture points on both sides of the impaired lumbar vertebrae.
文摘Objective:To observe the clinical effects of half puncture plus transcutaneous acupoint electric stimulation in the treatment of infantile facial paralysis. Methods:A total of 60 patients with infantile facial paralysis were divided into a treatment group and a control group by the random digital table, 30 cases in each group. The treatment group was treated with half puncture plus transcutaneous acupoint electric stimulation. The control group was treated with routine acupuncture. Before and after treatment, House-Brackmann (H-B) grading was used to evaluate the sick children respectively. The total effective rates were compared between the two groups after treatment. Results:After 6-course treatments, the total effective rate was 96.5% in the treatment group and 80.0% in the control group, there was a statistical difference between the two groups (P〈0.05) in comparison of the total effective rate. After 6-course treatments, H-B scores were all elevated than those before treatment in the two groups (P〈0.05); there was a statistical difference between the two groups (P〈0.05). Conclusion:Half puncture plus transcutaneous acupoint electric stimulation is better than routine acupuncture in curative effect for infantile facial paralysis.
基金supported by the Top Talent Program of Heilongjiang University of Traditional Chinese Medicine,No.2012RCL02Science & Technology Innovation Team Program in Heilongjiang Colleges and Universities,No.2013TD007~~
文摘Objective:To observe the clinical efficacy of electroacupuncture (EA) combined with iontophoresis of Chinese medicine for lumbar intervertebral disc herniation (LIDH). Methods: A total of 80 LIDH cases were randomly allocated into a treatment group and a control group by the random number table, 40 in each group. Cases in the treatment group were treated with EA combined with iontophoresis of Chinese medicine, whereas cases in the control group were treated with EA alone. Cases in both groups were treated once a day, 10 times for one course and there was a 3-day interval between two courses. The therapeutic efficacies in two groups were assessed after two courses of treatment. The short-form McGill pain questionnaire (SF-MPQ) and Japanese Orthopedic Association (JOA) low back pain evaluation questionnaire were used for the scoring system before treatment, after the first treatment and 2 courses of treatment. Results: After two courses of treatment, the total effective rate was 95.0% in the treatment group, versus 87.5% in the control group, showing a statistical difference (P〈0.05). The therapeutic efficacy in the treatment group was significantly better than that in the control group after the first treatment and 2 courses of treatment. The score of SF-MPQ in the treatment group was more significantly decreased and the JOA score in the treatment group was more significantly increased, showing statistical differences (P〈0.01). Conclusion: EA at Jiaji (EX-B2) points combined with iontophoresis of Chinese medicine is better than EA alone in alleviating low back and leg pain and improving functions of the low back and leg as well as the quality of life of LIDH patients .
文摘Objective:To explore the therapeutic efficacy and mechanism of transcutaneous electrical acupoint stimulation(TEAS)for menopausal insomnia.Methods:A total of 80 patients with menopausal insomnia were randomly divided into a control group and an observation group,with 40 cases in each group.The patients in the control group received conventional Western medication treatment,and the patients in the observation group received TEAS on the basis of conventional Western medication treatment.The treatment for both groups lasted for 4 weeks.Before and after treatment,Pittsburgh sleep quality index(PSQI)and modified Kupperman scale were evaluated,and the serum levels of estradiol(E2)and follicular stimulating hormone(FSH)were measured.The therapeutic efficacy was evaluated after treatment.Results:After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);in the control group,the improvement of PSQI score was significant(P<0.05),while the change of modified Kupperman score was insignificant(P>0.05);the PSQI and Kupperman scores in the observation group were significantly improved after treatment(both P<0.05),and there were significant differences between the observation group and the control group in PSQI and Kupperman scores(both P<0.05).After treatment,the serum E2 and FSH levels in the control group were not statistically different from those before treatment(both P>0.05);the serum E2 level was significantly increased(P<0.05),and the FSH level was decreased(P<0.05)in the observation group after treatment,and the between-group differences in serum levels of E2 and FSH were significant(both P<0.05).Conclusion:TEAS plus conventional Western medication in treating menopausal insomnia is effective,and can significantly improve the symptoms of insomnia and menopause,which may be related to the regulation of serum E2 and FSH levels.