Endogenous electric fields （EFs） have been detected at wounds and damaged tissues. The potential roles of EFs in tissue repair and regeneration have been an intriguing topic for centuries. Recent researches have pro...Endogenous electric fields （EFs） have been detected at wounds and damaged tissues. The potential roles of EFs in tissue repair and regeneration have been an intriguing topic for centuries. Recent researches have provided significant insights into how naturally occurring EFs may participate in the control of tissue repair and regeneration. Applied EFs equivalent to the size of fields measured in vivo direct cell migration, cell proliferation and nerve sprouting at wounds. More remarkably, physiological EFs are a guidance cue that directs cell migration which overrides other well accepted directional signals including initial injury stimulation, wound void, contact inhibition release, population pressure and chemotaxis. EFs activate many intracellular signaling pathways in a directional manner. Modulation of endogenous wound EFs affects epithelial cell migration, cell proliferation, and nerve growth at cornea wounds in vivo. Electric stimulation is being tested clinically for the treatments of bone fracture, wound healing and spinal cord injury. EFs thus may represent a novel type of signaling paradigm in tissue repair and regeneration. Combination of the electric stimulation and other well understood biochemical regulatory mechanisms may offer powerful and effective therapies for tissue repair and regeneration. This review introduces experimental evidence for the existence of endogenous EFs and discusses their roles in tissue repair and regeneration.展开更多
The possibility to achieve unprecedented multiplexing of light-matter interaction in nanoscale is of virtue importance from both fundamental science and practical application points of view. Cylindrical vector beams(C...The possibility to achieve unprecedented multiplexing of light-matter interaction in nanoscale is of virtue importance from both fundamental science and practical application points of view. Cylindrical vector beams(CVBs) manifested as polarization vortices represent a robust and emerging degree of freedom for information multiplexing with increased capacities. Here, we propose and demonstrate massivelyencoded optical data storage(ODS) by harnessing spatially variant electric fields mediated by segmented CVBs. By tight focusing polychromatic segmented CVBs to plasmonic nanoparticle aggregates, recordhigh multiplexing channels of ODS through different combinations of polarization states and wavelengths have been experimentally demonstrated with a low error rate. Our result not only casts new perceptions for tailoring light-matter interactions utilizing structured light but also enables a new prospective for ultra-high capacity optical memory with minimalist system complexity by combining CVB’s compatibility with fiber optics.展开更多
基金This research was supported by the National Natural Science Foundation of China （No. 30871269）.Acknowledgement We are very grateful to Mr. Vu Tran （Dermatology, University of California Davis, USA） for his critical reading of this manuscript.
文摘Endogenous electric fields （EFs） have been detected at wounds and damaged tissues. The potential roles of EFs in tissue repair and regeneration have been an intriguing topic for centuries. Recent researches have provided significant insights into how naturally occurring EFs may participate in the control of tissue repair and regeneration. Applied EFs equivalent to the size of fields measured in vivo direct cell migration, cell proliferation and nerve sprouting at wounds. More remarkably, physiological EFs are a guidance cue that directs cell migration which overrides other well accepted directional signals including initial injury stimulation, wound void, contact inhibition release, population pressure and chemotaxis. EFs activate many intracellular signaling pathways in a directional manner. Modulation of endogenous wound EFs affects epithelial cell migration, cell proliferation, and nerve growth at cornea wounds in vivo. Electric stimulation is being tested clinically for the treatments of bone fracture, wound healing and spinal cord injury. EFs thus may represent a novel type of signaling paradigm in tissue repair and regeneration. Combination of the electric stimulation and other well understood biochemical regulatory mechanisms may offer powerful and effective therapies for tissue repair and regeneration. This review introduces experimental evidence for the existence of endogenous EFs and discusses their roles in tissue repair and regeneration.
基金the financial support from the National Key R&D Program of China (2018YFB1107200)the National Natural Science Foundation of China (91750110, 11674130, 61605061, 11674110 and 11874020)+2 种基金the Guangdong Provincial Innovation and Entrepreneurship Project (2016ZT06D081)the Natural Science Foundation of Guangdong Province (2016A030306016, 2016TQ03X981 and 2016A030308010)Pearl River S and T Nova Program of Guangzhou (201806010040)。
文摘The possibility to achieve unprecedented multiplexing of light-matter interaction in nanoscale is of virtue importance from both fundamental science and practical application points of view. Cylindrical vector beams(CVBs) manifested as polarization vortices represent a robust and emerging degree of freedom for information multiplexing with increased capacities. Here, we propose and demonstrate massivelyencoded optical data storage(ODS) by harnessing spatially variant electric fields mediated by segmented CVBs. By tight focusing polychromatic segmented CVBs to plasmonic nanoparticle aggregates, recordhigh multiplexing channels of ODS through different combinations of polarization states and wavelengths have been experimentally demonstrated with a low error rate. Our result not only casts new perceptions for tailoring light-matter interactions utilizing structured light but also enables a new prospective for ultra-high capacity optical memory with minimalist system complexity by combining CVB’s compatibility with fiber optics.
