Heine is an iron-containing tetrapyrrole that plays a critical role in regulating a variety of biological processes including oxy- gen and electron transport, gas sensing, signal transduction, biological clock, and mi...Heine is an iron-containing tetrapyrrole that plays a critical role in regulating a variety of biological processes including oxy- gen and electron transport, gas sensing, signal transduction, biological clock, and microRNA processing. Most metazoan cells synthesize heine via a conserved pathway comprised of eight enzyme-cataiyzed reactions. Heme can also be acquired from food or extracellular environment. Cellular heine homeostasis is maintained through the coordinated regulation of synthesis, transport, and degradation. This review presents the current knowledge of the synthesis and transport of heine in metazoans and highlights recent advances in the regulation of these pathways.展开更多
基金supported by the National Natural Science Foundation of China(31371435)the National Key Basic Research Program of China(2015CB150300)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Thousand Youth Talents Program of China
文摘Heine is an iron-containing tetrapyrrole that plays a critical role in regulating a variety of biological processes including oxy- gen and electron transport, gas sensing, signal transduction, biological clock, and microRNA processing. Most metazoan cells synthesize heine via a conserved pathway comprised of eight enzyme-cataiyzed reactions. Heme can also be acquired from food or extracellular environment. Cellular heine homeostasis is maintained through the coordinated regulation of synthesis, transport, and degradation. This review presents the current knowledge of the synthesis and transport of heine in metazoans and highlights recent advances in the regulation of these pathways.
