AIM: To clarify whether the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) after pancreatic guidewire placement (PGW) can be reduced by using a different cannulation ...AIM: To clarify whether the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) after pancreatic guidewire placement (PGW) can be reduced by using a different cannulation method. METHODS: BebNeen April 2001 and October 2009, PGW was performed in 142 patients with native papilla to overcome difficult biliary cannulation. Our cannulation method for ERCP was changed from contrast injection (CI) using a single-lumen catheter (April 2001-May 2008) to wire-guided cannulation (WGC) using a double-lumen catheter (June 2008-October 2009). The CI protocol was also changed during the study period: in the first period it was used for routine pancreatography for detecting small pancreatic cancer (April 2001-November 2002), whereas in the second period it was not (December 2002-May 2008). In PGW with CI using a single- lumen catheter, the contrast medium in the catheter lumen was injected into the pancreatic duct. The success rate of biliary cannulation, the incidence of PEP according to the cannulation method, and the impact of CI using a single-lumen catheter on PEP in comparison with WGC using a double-lumen catheter were investigated.RESULTS: CI with routine pancreatography, CI without routine pancreatography, and WGC were performed in 27 patients, 77 patients and 38 patients, respectively. Routine pancreatography did not contribute to the early diagnosis of pancreatic cancer in our study period. In CI without routine pancreatography and WGC, diagnostic pancreatography was performed in 17 patients and no patients, respectively. The success rate of biliary cannulation by PGW alone was 69%, and the final success rate was increased to 80.3% by the addition of consecutive maneuvers or a second ERCP. PEP occurred in 22 patients (15.5%), and the severity was mild in all cases. When analyzed according to cannulation method, the incidence of PEP was 37.0% (10/27) in the patients who underwent CI with routine pancreatography, 14.3% (11/77) in those who underwent CI without routine pancreatography, and 2.6% (1/38) in those who underwent WGC. In all patients who underwent CI using a singlelumen catheter, the incidence of PEP was 20% (21/104), which was significantly higher than that in WGC using a double-lumen catheter. In univariate and multivariate analysis, CI using a single-lumen catheter showed a high, statistically significant, odds ratio for PEP after PGW. CONCLUSION: The practice of a cannulation method involving the use of a double-lumen catheter minimizes the CI dose administered to the pancreatic duct and reduces the incidence of PEP after PGW.展开更多
Micro-light emitting diode(micro-LED)is an emerging display technology with excellent performance of high contrast,low power consumption,long lifetime,and fast response time compared with the current display(e.g.,liqu...Micro-light emitting diode(micro-LED)is an emerging display technology with excellent performance of high contrast,low power consumption,long lifetime,and fast response time compared with the current display(e.g.,liquid crystal and organic LED(OLED)).With technological advantages,micro-LED holds promise to be widely applied in augmented reality(AR),flexible screens,etc.and is thus regarded as the next generation of display technology.In the process flow of micro-LED,the step known as mass transfer that requires transferring millions of micro-LEDs from a growth substrate to a display plane,is one of the key challenges limiting the commercialization of micro-LED from laboratory.Worldwide academic and industrial efforts have been devoted to developing mass transfer strategies with purposes of improving yield and reducing cost.Herein we review three main categories of mass transfer technologies for micro-LED display(pick-and-place,fluid self-assembly and laser-enabled advanced placement)and the coupled detection and repair technologies after transfer.Discussions and comparisons have been provided about the underlying general principle,history,and representative parties,advantages,and disadvantages(yield/efficiency/cost)of these technologies.We further envision the application prospect of these transfer technologies and the promise of the future display of micro-LED.展开更多
Abstract The structural and energetic properties of bimetallic AgmCun (m +n ≤ 5) in the cationic and anionic charged states have been investigated by density functional theory with relativistic effective core pote...Abstract The structural and energetic properties of bimetallic AgmCun (m +n ≤ 5) in the cationic and anionic charged states have been investigated by density functional theory with relativistic effective core potentails. The stable cationic pentamers have three-dimensional structures in contrast to anionic clusters assume planar structures. For the given cluster size the electron affinities decrease as the Cu content increases, while no clear trend can be found in adiabatic ionization potentials. The binding energy per atom also increases with the increasing Cu content and follows the order anion 〈 cation. The most probable dissociation channels of the clusters considered are also discussed.展开更多
文摘AIM: To clarify whether the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) after pancreatic guidewire placement (PGW) can be reduced by using a different cannulation method. METHODS: BebNeen April 2001 and October 2009, PGW was performed in 142 patients with native papilla to overcome difficult biliary cannulation. Our cannulation method for ERCP was changed from contrast injection (CI) using a single-lumen catheter (April 2001-May 2008) to wire-guided cannulation (WGC) using a double-lumen catheter (June 2008-October 2009). The CI protocol was also changed during the study period: in the first period it was used for routine pancreatography for detecting small pancreatic cancer (April 2001-November 2002), whereas in the second period it was not (December 2002-May 2008). In PGW with CI using a single- lumen catheter, the contrast medium in the catheter lumen was injected into the pancreatic duct. The success rate of biliary cannulation, the incidence of PEP according to the cannulation method, and the impact of CI using a single-lumen catheter on PEP in comparison with WGC using a double-lumen catheter were investigated.RESULTS: CI with routine pancreatography, CI without routine pancreatography, and WGC were performed in 27 patients, 77 patients and 38 patients, respectively. Routine pancreatography did not contribute to the early diagnosis of pancreatic cancer in our study period. In CI without routine pancreatography and WGC, diagnostic pancreatography was performed in 17 patients and no patients, respectively. The success rate of biliary cannulation by PGW alone was 69%, and the final success rate was increased to 80.3% by the addition of consecutive maneuvers or a second ERCP. PEP occurred in 22 patients (15.5%), and the severity was mild in all cases. When analyzed according to cannulation method, the incidence of PEP was 37.0% (10/27) in the patients who underwent CI with routine pancreatography, 14.3% (11/77) in those who underwent CI without routine pancreatography, and 2.6% (1/38) in those who underwent WGC. In all patients who underwent CI using a singlelumen catheter, the incidence of PEP was 20% (21/104), which was significantly higher than that in WGC using a double-lumen catheter. In univariate and multivariate analysis, CI using a single-lumen catheter showed a high, statistically significant, odds ratio for PEP after PGW. CONCLUSION: The practice of a cannulation method involving the use of a double-lumen catheter minimizes the CI dose administered to the pancreatic duct and reduces the incidence of PEP after PGW.
基金supported by the National ScienceFoundation for Distinguished Young Scholars(51925301)the National Natural Science Foundation of China(52122315 and 21972008)+3 种基金Beijing Nova Program(Z201100006820021)the Fundamental Research Funds for the Central Universities(XK1902)the Wanren Plan(wrjh201903)the Open Project of State Key Laboratory(sklssm2022)。
文摘Micro-light emitting diode(micro-LED)is an emerging display technology with excellent performance of high contrast,low power consumption,long lifetime,and fast response time compared with the current display(e.g.,liquid crystal and organic LED(OLED)).With technological advantages,micro-LED holds promise to be widely applied in augmented reality(AR),flexible screens,etc.and is thus regarded as the next generation of display technology.In the process flow of micro-LED,the step known as mass transfer that requires transferring millions of micro-LEDs from a growth substrate to a display plane,is one of the key challenges limiting the commercialization of micro-LED from laboratory.Worldwide academic and industrial efforts have been devoted to developing mass transfer strategies with purposes of improving yield and reducing cost.Herein we review three main categories of mass transfer technologies for micro-LED display(pick-and-place,fluid self-assembly and laser-enabled advanced placement)and the coupled detection and repair technologies after transfer.Discussions and comparisons have been provided about the underlying general principle,history,and representative parties,advantages,and disadvantages(yield/efficiency/cost)of these technologies.We further envision the application prospect of these transfer technologies and the promise of the future display of micro-LED.
基金Supported by the National Natural Science Foundation of China under Grant No. 20873036the Fund for Doctorates of Henan University of Science and Technology
文摘Abstract The structural and energetic properties of bimetallic AgmCun (m +n ≤ 5) in the cationic and anionic charged states have been investigated by density functional theory with relativistic effective core potentails. The stable cationic pentamers have three-dimensional structures in contrast to anionic clusters assume planar structures. For the given cluster size the electron affinities decrease as the Cu content increases, while no clear trend can be found in adiabatic ionization potentials. The binding energy per atom also increases with the increasing Cu content and follows the order anion 〈 cation. The most probable dissociation channels of the clusters considered are also discussed.