This paper establishes a 3D numerical model for 15# hydropower house of the Three Gorges Project (TGP) and performs a nonlinear static and dynamic damage analysis. In this numerical model, a coupling model of finite a...This paper establishes a 3D numerical model for 15# hydropower house of the Three Gorges Project (TGP) and performs a nonlinear static and dynamic damage analysis. In this numerical model, a coupling model of finite and infinite elements for simulating infinite foundation of hydropower station is adopted. A plastic-damage model based on continuum damage mechanics, which includes the softening and damage behavior under tension is considered for the concrete material. The dynamic equilibrium equations of moti...展开更多
Environmental micro-vibration is one of the key factors impacting the running of electronic workshop.Low frequency micro-vibration has a significant influence on the normal operation of high precision machining and te...Environmental micro-vibration is one of the key factors impacting the running of electronic workshop.Low frequency micro-vibration has a significant influence on the normal operation of high precision machining and testing equipment,and even causes irreversible damage to the equipment.Micro-vibration testing and response analysis are important to guide the vibration isolation design and ensure the stable operation of various precision equipment in the workshop.Parameters of Davidenkov model are fitted based on whale swarm optimization algorithm,and its applicability is verified.At the same time,taking the testing project of an electronic workshop raw land as an example,the micro-vibration response is analyzed.The results show that the nonlinear constitutive model constructed by whale optimization algorithm can simulate the dynamic nonlinear behavior of soil under the action of micro-vibration better.Compared with the traditional equivalent linearization method,the nonlinear constitutive model based on the whale optimization algorithm has a smaller acceleration response value.It can effectively suppress the“virtual resonance effect”produced by the equivalent linearization method.展开更多
Objective To explore the effect of allocryptopine （All） on the Late sodium current （INa,Late） of atrial myocytes in spontaneously hyper- tensive rats （SHR）. Method The enzyme digestion method was used to separat...Objective To explore the effect of allocryptopine （All） on the Late sodium current （INa,Late） of atrial myocytes in spontaneously hyper- tensive rats （SHR）. Method The enzyme digestion method was used to separate single atrial myocytes from SHR and Wistar-Kyoto rat （WKY） rats. INa,Late was record by patch-clamp technique and the effect of All on the current was evaluated. Results Comparing with WKY cells, markedly increasing of INa,Late current in SHR myocytes was found from 0.24 ± 0.02 pA/pF of WKY cells to 1.73± 0.04 pA/pF of SHR cells （P 〈 0.01, n = 15）. After treament with 30 μmol/L All; the current densities was reduced to 0.92 ± 0.03 pA/pF. The ratio of INa,Late/INa,peak of WKY and SHR were 0.09% ± 0.01% and 0.71% ± 0.02%, INa, Late/INa,peak of SHR was reduced to 0.37% ± 0.02% by 30 μmol/L All （P 〈 0.01, n = 15）. We also determined the effect of All on the gating mechanism of the INa,Late in the SHR cells. It was found that All decreased the INa,Late by alleviating the inactivation of the channels and increasing the window current of sodium channel. Conclusion Increased INa,Late in SHR atrial myocytes and the prolonged APD were inhibited by All coming from Chinese herb medicine.展开更多
基金Supported by National Natural Science Foundation of China (No.50679009)Key Laboratory for Scientific Research of Department of Education in Liaoning Province (No.2008S045)
文摘This paper establishes a 3D numerical model for 15# hydropower house of the Three Gorges Project (TGP) and performs a nonlinear static and dynamic damage analysis. In this numerical model, a coupling model of finite and infinite elements for simulating infinite foundation of hydropower station is adopted. A plastic-damage model based on continuum damage mechanics, which includes the softening and damage behavior under tension is considered for the concrete material. The dynamic equilibrium equations of moti...
文摘Environmental micro-vibration is one of the key factors impacting the running of electronic workshop.Low frequency micro-vibration has a significant influence on the normal operation of high precision machining and testing equipment,and even causes irreversible damage to the equipment.Micro-vibration testing and response analysis are important to guide the vibration isolation design and ensure the stable operation of various precision equipment in the workshop.Parameters of Davidenkov model are fitted based on whale swarm optimization algorithm,and its applicability is verified.At the same time,taking the testing project of an electronic workshop raw land as an example,the micro-vibration response is analyzed.The results show that the nonlinear constitutive model constructed by whale optimization algorithm can simulate the dynamic nonlinear behavior of soil under the action of micro-vibration better.Compared with the traditional equivalent linearization method,the nonlinear constitutive model based on the whale optimization algorithm has a smaller acceleration response value.It can effectively suppress the“virtual resonance effect”produced by the equivalent linearization method.
基金This work was supported by the grant from the National Natural Science Foundation of China （grant number. No： 81030002,81170177, 81100215, 81373835）.
文摘Objective To explore the effect of allocryptopine （All） on the Late sodium current （INa,Late） of atrial myocytes in spontaneously hyper- tensive rats （SHR）. Method The enzyme digestion method was used to separate single atrial myocytes from SHR and Wistar-Kyoto rat （WKY） rats. INa,Late was record by patch-clamp technique and the effect of All on the current was evaluated. Results Comparing with WKY cells, markedly increasing of INa,Late current in SHR myocytes was found from 0.24 ± 0.02 pA/pF of WKY cells to 1.73± 0.04 pA/pF of SHR cells （P 〈 0.01, n = 15）. After treament with 30 μmol/L All; the current densities was reduced to 0.92 ± 0.03 pA/pF. The ratio of INa,Late/INa,peak of WKY and SHR were 0.09% ± 0.01% and 0.71% ± 0.02%, INa, Late/INa,peak of SHR was reduced to 0.37% ± 0.02% by 30 μmol/L All （P 〈 0.01, n = 15）. We also determined the effect of All on the gating mechanism of the INa,Late in the SHR cells. It was found that All decreased the INa,Late by alleviating the inactivation of the channels and increasing the window current of sodium channel. Conclusion Increased INa,Late in SHR atrial myocytes and the prolonged APD were inhibited by All coming from Chinese herb medicine.
