Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim ...Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was in- creased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.展开更多
Objective To compare the therapeutic effect on simple obesity of gastrointestinal heat type between electroacupuncture (EA) and conventional acupuncture (CA). Methods Ninety cases of simple obesity of gastrointest...Objective To compare the therapeutic effect on simple obesity of gastrointestinal heat type between electroacupuncture (EA) and conventional acupuncture (CA). Methods Ninety cases of simple obesity of gastrointestinal heat type were randomized into an EA group and a CA group, 45 cases in each one. In the EA group, CA was applied at Neiting (内庭 ST 44), Shangjuxu (上巨虚 ST 37), Xiajuxu (下巨虚 ST 39), Fenglong (丰隆 ST 40), Tianshu (天枢 ST 25), Zusanli (足三里 ST 36), YTnlingquan (阴陵泉 SP 9) and Ouchi (曲池 LI 12). The electric stimulation was attached at ST 37, ST 44, ST 25 and ST 40. In CA group, the simple acupuncture was applied at the same points as the EA group. The treatment was given once every two days, 22 treatments made one session and 3 sessions were required totally in the two groups. The changes in body mass, obesity degree, body mass index (BMI) and body fat percentage (F%) were observed in the patients before and after treatment. The therapeutic effects on weight loss and fat loss were compared between the two groups. Results After treatment, the weight, obesity degree, BMI and F% were all reduced apparently in the patients of the two groups (all P〈0.01). After the 2st session of treatment, concerning to the effect on weight loss, the total effective rate in the EA group was superior to that in the CA group [95.6% (43/45) vs 77.8% (35/45), P〈0.05]. The effects were not different apparently between the two groups in the later 2 sessions of treatment (all P〉0.05). The effect on fat loss was not different significantly in statistics between EA and CA (all P〉0.05). Conclusion Either EA or CA achieves the significant effect on simple obesity. The therapeutic effect of EA on weight loss in the early stage is obviously superior to that of CA.展开更多
文摘Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was in- creased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.
基金Naional Natural Science Fund Project: 30873307Jiangsu Characterisic Preponderant Discipline Fund ProjectFund Project of Outstanding Innovaion Team of Science and Technology in Jiangsu Colleges and Universiies Qinglan Engineering
文摘Objective To compare the therapeutic effect on simple obesity of gastrointestinal heat type between electroacupuncture (EA) and conventional acupuncture (CA). Methods Ninety cases of simple obesity of gastrointestinal heat type were randomized into an EA group and a CA group, 45 cases in each one. In the EA group, CA was applied at Neiting (内庭 ST 44), Shangjuxu (上巨虚 ST 37), Xiajuxu (下巨虚 ST 39), Fenglong (丰隆 ST 40), Tianshu (天枢 ST 25), Zusanli (足三里 ST 36), YTnlingquan (阴陵泉 SP 9) and Ouchi (曲池 LI 12). The electric stimulation was attached at ST 37, ST 44, ST 25 and ST 40. In CA group, the simple acupuncture was applied at the same points as the EA group. The treatment was given once every two days, 22 treatments made one session and 3 sessions were required totally in the two groups. The changes in body mass, obesity degree, body mass index (BMI) and body fat percentage (F%) were observed in the patients before and after treatment. The therapeutic effects on weight loss and fat loss were compared between the two groups. Results After treatment, the weight, obesity degree, BMI and F% were all reduced apparently in the patients of the two groups (all P〈0.01). After the 2st session of treatment, concerning to the effect on weight loss, the total effective rate in the EA group was superior to that in the CA group [95.6% (43/45) vs 77.8% (35/45), P〈0.05]. The effects were not different apparently between the two groups in the later 2 sessions of treatment (all P〉0.05). The effect on fat loss was not different significantly in statistics between EA and CA (all P〉0.05). Conclusion Either EA or CA achieves the significant effect on simple obesity. The therapeutic effect of EA on weight loss in the early stage is obviously superior to that of CA.