Long-time driving and monotonous visual environment increase the safety risk of driving in an extra-long tunnel. Driving fatigue can be effectively relieved by setting the visual fatigue relief zone in the tunnel. How...Long-time driving and monotonous visual environment increase the safety risk of driving in an extra-long tunnel. Driving fatigue can be effectively relieved by setting the visual fatigue relief zone in the tunnel. However, the setting form of visual fatigue relief zone, such as its length and location, is difficult to be designed and quantified. By integrating virtual reality(VR) apparatus with wearable electroencephalogram(EEG)-based devices, a hybrid method was proposed in this study to assist analyzers to formulate the layout of visual fatigue relief zone in the extra-long tunnel.The virtual environment of this study was based on an 11.5 km extra-long tunnel located in Yunnan Province in China.The results indicated that the use of natural landscape decoration inside the tunnel could improve driving fatigue with the growth rate of attention of the driver increased by more than 20%. The accumulation of driving fatigue had a negative effect on the fatigue relief. The results demonstrated that the optimal location of the fatigue relief zone was at the place where driving fatigue had just occurred rather than at the place where a certain amount of driving fatigue had accumulated.展开更多
Objective： To investigate the mechanism of electroacupuncturein treating chronic fatigue syndrome（CFS） in term of the neuro-endocrine system by observing the regulative effect of EA on hypothalamic-pituitary-adrena...Objective： To investigate the mechanism of electroacupuncturein treating chronic fatigue syndrome（CFS） in term of the neuro-endocrine system by observing the regulative effect of EA on hypothalamic-pituitary-adrenal index （HPA index） and corticotropin releasing hormone mRNA （CRH mRNA） in CFS model rats. Methods： The rats were randomly divided into control group, model group, and electroacupuncture group. Model and electroacupuncture groups were forced to swim in cold water to make CFS model, while rats in electroacupuncture group were treated with electroacupuncture treatment at the same time. Electroacupuncture group was given at Baihui（GV 20） and Zusanli（ST 36）. Evaluation of the model was processed according to the behavior changes of the rats. Hypothalamic, pituitary, and adrenal were weighted to calculate HPA index. CRH mRNA in hypothalamic was measured by fluorescence quantitative polymerase chain reaction （FQPCR）. Results： The model rats had behavior changes, and both physical and mental fatigue was observed. HPA index raised and expression of CRH mRNA in hypothalamus increased in CFS rats. After electroacupuncture treatment, the physical and mental fatigue was improved, and the hypothalamic index and CRH mRNA decreased significantly, while the pituitary and adrenal index only had little decrease. Conclusion： Cold water swim press could mimic the pathogenesis and make similar manifestations in rats with the common clinical symptoms. CFS has close relationship with increase of HPA index and CRH mRNA expression. Electroacupuncture can regulate the function of HPA axis to deal with CFS.展开更多
基金Project(2018YFB2101000) supported by the National Key R&D Program of ChinaProject(20YF1451400) supported by Shanghai Sailing Program,ChinaProject(SLDRCE19-A-14) supported by the Research Fund of State Key Laboratory for Disaster Reduction in Civil Engineering,China。
文摘Long-time driving and monotonous visual environment increase the safety risk of driving in an extra-long tunnel. Driving fatigue can be effectively relieved by setting the visual fatigue relief zone in the tunnel. However, the setting form of visual fatigue relief zone, such as its length and location, is difficult to be designed and quantified. By integrating virtual reality(VR) apparatus with wearable electroencephalogram(EEG)-based devices, a hybrid method was proposed in this study to assist analyzers to formulate the layout of visual fatigue relief zone in the extra-long tunnel.The virtual environment of this study was based on an 11.5 km extra-long tunnel located in Yunnan Province in China.The results indicated that the use of natural landscape decoration inside the tunnel could improve driving fatigue with the growth rate of attention of the driver increased by more than 20%. The accumulation of driving fatigue had a negative effect on the fatigue relief. The results demonstrated that the optimal location of the fatigue relief zone was at the place where driving fatigue had just occurred rather than at the place where a certain amount of driving fatigue had accumulated.
文摘Objective： To investigate the mechanism of electroacupuncturein treating chronic fatigue syndrome（CFS） in term of the neuro-endocrine system by observing the regulative effect of EA on hypothalamic-pituitary-adrenal index （HPA index） and corticotropin releasing hormone mRNA （CRH mRNA） in CFS model rats. Methods： The rats were randomly divided into control group, model group, and electroacupuncture group. Model and electroacupuncture groups were forced to swim in cold water to make CFS model, while rats in electroacupuncture group were treated with electroacupuncture treatment at the same time. Electroacupuncture group was given at Baihui（GV 20） and Zusanli（ST 36）. Evaluation of the model was processed according to the behavior changes of the rats. Hypothalamic, pituitary, and adrenal were weighted to calculate HPA index. CRH mRNA in hypothalamic was measured by fluorescence quantitative polymerase chain reaction （FQPCR）. Results： The model rats had behavior changes, and both physical and mental fatigue was observed. HPA index raised and expression of CRH mRNA in hypothalamus increased in CFS rats. After electroacupuncture treatment, the physical and mental fatigue was improved, and the hypothalamic index and CRH mRNA decreased significantly, while the pituitary and adrenal index only had little decrease. Conclusion： Cold water swim press could mimic the pathogenesis and make similar manifestations in rats with the common clinical symptoms. CFS has close relationship with increase of HPA index and CRH mRNA expression. Electroacupuncture can regulate the function of HPA axis to deal with CFS.
