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电致孔经皮给药配合刺络拔罐治疗肩周炎60例 被引量:1
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作者 赵玉娟 付焕香 时晶 《中医药导报》 2013年第12期87-88,共2页
肩周炎,即肩关节周围炎,祖国医学称之为“漏肩风”又称“五十肩”、“冻结肩”,是以肩部疼痛和功能障碍为主要症状的常见病症[1],主要见于中老年患者,本病好发年龄在50岁左右,女性发病率明显高于男性,多见于体力劳动者,严重影响患者肩... 肩周炎,即肩关节周围炎,祖国医学称之为“漏肩风”又称“五十肩”、“冻结肩”,是以肩部疼痛和功能障碍为主要症状的常见病症[1],主要见于中老年患者,本病好发年龄在50岁左右,女性发病率明显高于男性,多见于体力劳动者,严重影响患者肩关节功能及生活质量.我院采用电致孔经皮给药配合刺络拔罐治疗本病患者60例,取得一定疗效,现报告如下. 展开更多
关键词 电致孔经皮给药 刺络拔罐 肩周炎
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Transdermal Drug Delivery by Electroporation: The Effects of Surfactants on Pathway Lifetime and Drug Transport 被引量:1
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作者 蒋国强 朱德权 +1 位作者 昝佳 丁富新 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2007年第3期397-402,共6页
Electroporation creates aqueous pathways by short high-voltage pulses resulting in a transient perme- abilization of stratum corneum and an increase in the transdermal delivery rate.However the aqueous pathways will r... Electroporation creates aqueous pathways by short high-voltage pulses resulting in a transient perme- abilization of stratum corneum and an increase in the transdermal delivery rate.However the aqueous pathways will reseal after pulsing,which leads to the rapid drop of transdermal flux.In the present study,the surfactants were added to the donor solution to hinder the shrinkage and resealing of the electropore,and to prolong the lifetime of the aqueous pathways with the consideration that the surfactants could reduce the surface energy of the electropore. These effects of surfactants were demonstrated by the dynamic electrical resistance of the skin and the fluorescent imaging of the local transport regions.Piroxicam(PIX)was transported percutaneously in the presence of surfac- tants in vitro.Owing to the longer lifetime of aqueous pathways,together with the promotion of PIX availability at the barrier exterior and the improvement in the partition of PIX into the aqueous pathways,the presence of surfac- tants led to a remarkable increase in the transdermal delivery rate during electroporation and a significant growth of the accumulative transdermal amount of PIX. 展开更多
关键词 transdermal drug delivery skin electroporation SURFACTANT aqueous pathway
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