目的 基于CiteSpace和VOSviewer探讨心房颤动(以下简称“房颤”)与电重构研究的热点与趋势。方法 检索2004年1月至2021年12月Web of Science数据库中有关房颤和电重构研究的文献,利用Cite Space 5.8.R3、VOSviewer 1.6.16绘制国家、机...目的 基于CiteSpace和VOSviewer探讨心房颤动(以下简称“房颤”)与电重构研究的热点与趋势。方法 检索2004年1月至2021年12月Web of Science数据库中有关房颤和电重构研究的文献,利用Cite Space 5.8.R3、VOSviewer 1.6.16绘制国家、机构、作者、关键词可视化图谱。结果 共纳入1 178篇文献,发文量整体呈上升趋势。美国是最高产的国家,蒙特利尔大学是最具影响力的科研机构,Nattle S是发文最多的作者。心房重构、电重构、机制、风险等是该领域的高频和高中介中心性关键词,纤维化是突发强度最强的关键词。结论 房颤与电重构领域的研究热度处于持续上升阶段,主要研究热点是电重构机制、离子通道的变化、房颤的治疗和危险因素的预防,纤维化是未来研究的趋势。展开更多
Electrical remodeling in atrial fibrillation(AF)is considered to beget AF.However,in AF,decreased expressions of introverted ion currents INa and ICa channel proteins are corresponding to the induced increase of ion c...Electrical remodeling in atrial fibrillation(AF)is considered to beget AF.However,in AF,decreased expressions of introverted ion currents INa and ICa channel proteins are corresponding to the induced increase of ion concentration in cells to maintain the membranes’polarity;ITo is phase 1 instantaneous extraverted K+current,IKur is the important extraverted K+current in phases 1 and 2,IKr,IKs are the main extraverted current in phase 2,and the ion channel proteins of them are down-regulated in AF to prolong atrial effective refractory period(AERP),which is disadvantageous to reentry;IK1,IKAch,IKATP work in phase 3,and their up-regulated channel proteins amplify myocardium diastolic potential,lower the myocardium excitability and reduce the ectopic excitement.Therefore,in AF,atrial electrical remodeling is not to beget AF,but to restore its physiological function.AF begets AF in that it can cause atrial structural remodeling,and the structural remodeling facilitates AF initiation and perpetuation.The interaction eventually aggravates atrial muscle injury and induces myocardial electrical disorder.展开更多
目的研究丹参酮ⅡA磺酸钠(TSN)对家兔在体心房单相动作电位(AMAP)及短期快速心房起搏时电重构的影响,探讨其防治房颤的可能机制。方法家兔24只,随机分为对照组与TSN组各12只。将电极经颈内静脉置入右心房记录AMAP,观察基础状态下、给药...目的研究丹参酮ⅡA磺酸钠(TSN)对家兔在体心房单相动作电位(AMAP)及短期快速心房起搏时电重构的影响,探讨其防治房颤的可能机制。方法家兔24只,随机分为对照组与TSN组各12只。将电极经颈内静脉置入右心房记录AMAP,观察基础状态下、给药后0.5 h及以600次.m in-1心房快速起搏后0.5 h、8 h AMAP及其频率适应性的变化。结果与起搏前相比对照组AERP200 m s在起搏后0.5h缩短21.2 m s,起博后8h缩短21.6m s(P<0.05),且心房肌的频率适应性丧失。TSN在基础状态下对AMAPA、AMAPD无明显影响,但使AERP200 m s由(105.9±3.8)m s延长至(114.7±7.2)m s(P<0.05)。起搏后TSN组维持原有的心房肌频率适应性。结论快速心房起搏使心房肌的频率适应性丧失而致电重构,TSN能通过抑制L-型钙通道减轻短期快速心房起搏所致电重构。展开更多
文摘Electrical remodeling in atrial fibrillation(AF)is considered to beget AF.However,in AF,decreased expressions of introverted ion currents INa and ICa channel proteins are corresponding to the induced increase of ion concentration in cells to maintain the membranes’polarity;ITo is phase 1 instantaneous extraverted K+current,IKur is the important extraverted K+current in phases 1 and 2,IKr,IKs are the main extraverted current in phase 2,and the ion channel proteins of them are down-regulated in AF to prolong atrial effective refractory period(AERP),which is disadvantageous to reentry;IK1,IKAch,IKATP work in phase 3,and their up-regulated channel proteins amplify myocardium diastolic potential,lower the myocardium excitability and reduce the ectopic excitement.Therefore,in AF,atrial electrical remodeling is not to beget AF,but to restore its physiological function.AF begets AF in that it can cause atrial structural remodeling,and the structural remodeling facilitates AF initiation and perpetuation.The interaction eventually aggravates atrial muscle injury and induces myocardial electrical disorder.
文摘目的研究丹参酮ⅡA磺酸钠(TSN)对家兔在体心房单相动作电位(AMAP)及短期快速心房起搏时电重构的影响,探讨其防治房颤的可能机制。方法家兔24只,随机分为对照组与TSN组各12只。将电极经颈内静脉置入右心房记录AMAP,观察基础状态下、给药后0.5 h及以600次.m in-1心房快速起搏后0.5 h、8 h AMAP及其频率适应性的变化。结果与起搏前相比对照组AERP200 m s在起搏后0.5h缩短21.2 m s,起博后8h缩短21.6m s(P<0.05),且心房肌的频率适应性丧失。TSN在基础状态下对AMAPA、AMAPD无明显影响,但使AERP200 m s由(105.9±3.8)m s延长至(114.7±7.2)m s(P<0.05)。起搏后TSN组维持原有的心房肌频率适应性。结论快速心房起搏使心房肌的频率适应性丧失而致电重构,TSN能通过抑制L-型钙通道减轻短期快速心房起搏所致电重构。