We report the case of a 41-year-old man presenting with hepatic vein thrombosis (Budd-Chiari syndrome) during Infliximab therapy for ankylosing spondylitis. The systematic work-up revealed paroxysmal nocturnal hemoglo...We report the case of a 41-year-old man presenting with hepatic vein thrombosis (Budd-Chiari syndrome) during Infliximab therapy for ankylosing spondylitis. The systematic work-up revealed paroxysmal nocturnal hemoglobinuria. One year later the patient was receiving anticoagulation therapy and was in good condition. The role of Infliximab in the development of thrombosis in this patient with rare underlying thrombophilia is discussed.展开更多
We report the case of a 65-year-old man with advanced hepatocellular carcinoma related to alcoholic cirrhosis who was hospitalised for oliguric renal failure. Investigations showed a severe nephrotic syndrome related ...We report the case of a 65-year-old man with advanced hepatocellular carcinoma related to alcoholic cirrhosis who was hospitalised for oliguric renal failure. Investigations showed a severe nephrotic syndrome related to paraneoplastic membranous glomerulonephritis. The patient s course was temporarily stabilized with loop diuretics and dialysis but the patient died of hemoperitoneum from a ruptured tumor.展开更多
Ischaemic colitis (IC) is themost frequent formof gastrointestinal ischaemia. Discrepancy between non- specific symptoms and objective findings is a hallmark of IC. Thus delay of diagnosis is common due to its often s...Ischaemic colitis (IC) is themost frequent formof gastrointestinal ischaemia. Discrepancy between non- specific symptoms and objective findings is a hallmark of IC. Thus delay of diagnosis is common due to its often subtle and unpredictable presentation. In particular, the clinical symptoms and signs of IC can overlap with those of inflammatory bowel disease. We present a case of a young man with known factor- V- Leiden mutation in whom IC developed during effective therapy with oral anticoagulants, presenting with symptoms and endoscopic findings suggestive of inflammatory bowel disease.展开更多
Objective： Male breast cancer （MBC） is a rare disease, and studies to compare the prognosis between the MBC and female breast cancer （FBC） available now were case-control studies and population-based studies, how...Objective： Male breast cancer （MBC） is a rare disease, and studies to compare the prognosis between the MBC and female breast cancer （FBC） available now were case-control studies and population-based studies, however, with controversial outcomes. To further investigate whether sex affects the prognosis of breast cancer, we performed a meta-analysis based on all the peered papers. Methods： The PubMed database was screened. Subsequently, the hazard ratios （HRs） for overall survival （OS） and disease special survival （DSS）, were pooled using the Review Manager 5.0 package. Results： This study comprised of 254 MBC and 733 FBC patients enrolled in six case-control studies. There was no statistically significant heterogeneity among the trials for either outcome variable. The pooled HR showed that there was no significant difference in 5-year or 10-year DSS （HR： 1.25, 95% CI： 0.76-2.08; HR： 1.04, 95% CI： 0.68-1.5g） and 5-year or 10-year OS （HR： 0.76, 95% CI： 0.51-1.14; HR： 0.74, 95% CI： 0.54-1.02） between MBCs and FBCs. Conclusion： MBC and FBC with similar prognosis are found in this meta-analysis based on only case-control studies which matched main potential prognostic factors such as age, clinical stage, and time at diagnosis.展开更多
Introduction:Rectal prolapse is a condition that occurs infrequently in men and there is little literature guiding treatment in this population.The purpose of this study was to evaluate the surgical approach and outco...Introduction:Rectal prolapse is a condition that occurs infrequently in men and there is little literature guiding treatment in this population.The purpose of this study was to evaluate the surgical approach and outcomes of rectal-prolapse repair in men.Methods:A retrospective multicenter review was conducted of consecutive men who underwent rectal-prolapse repair between 2004 and 2014.Surgical approaches and outcomes,including erectile function and fecal continence,were evaluated.Results:During the study period,58 men underwent rectal-prolapse repair and the mean age of repair was 52.7624.1 years.The mean follow-up was 13.2 months(range,0.5–117 months).The majority of patients underwent endoscopic evaluation(78%),but few patients underwent anal manometry(16%),defecography(9%)or ultrasound(3%).Ten patients(17%)underwent biofeedback/pelvic-floor physical therapy prior to repair.Nineteen patients(33%)underwent a perineal approach(most were perineal proctosigmoidectomy).Thirty-nine patients(67%)underwent repair using an abdominal approach(all were suture rectopexy)and,of these,77%were completed using a minimally invasive technique.The overall complication rate was 26%including urinary retention(16%),which was more common in patients undergoing the perineal approach(32%vs.8%,P=0.028),urinary-tract infection(7%)and wound infection(3%).The overall recurrence rate was 9%,with no difference between abdominal and perineal approaches.Information on sexual function was missing in the majority of patients both before and after surgery(76%and 78%,respectively).Conclusion:Rectal-prolapse repair in men is safe and has a low recurrence rate;however,sexual function was poorly recorded across all institutions.Further studies are needed to evaluate to best approach to and functional outcomes of rectal-prolapse repair in men.展开更多
文摘We report the case of a 41-year-old man presenting with hepatic vein thrombosis (Budd-Chiari syndrome) during Infliximab therapy for ankylosing spondylitis. The systematic work-up revealed paroxysmal nocturnal hemoglobinuria. One year later the patient was receiving anticoagulation therapy and was in good condition. The role of Infliximab in the development of thrombosis in this patient with rare underlying thrombophilia is discussed.
文摘We report the case of a 65-year-old man with advanced hepatocellular carcinoma related to alcoholic cirrhosis who was hospitalised for oliguric renal failure. Investigations showed a severe nephrotic syndrome related to paraneoplastic membranous glomerulonephritis. The patient s course was temporarily stabilized with loop diuretics and dialysis but the patient died of hemoperitoneum from a ruptured tumor.
文摘Ischaemic colitis (IC) is themost frequent formof gastrointestinal ischaemia. Discrepancy between non- specific symptoms and objective findings is a hallmark of IC. Thus delay of diagnosis is common due to its often subtle and unpredictable presentation. In particular, the clinical symptoms and signs of IC can overlap with those of inflammatory bowel disease. We present a case of a young man with known factor- V- Leiden mutation in whom IC developed during effective therapy with oral anticoagulants, presenting with symptoms and endoscopic findings suggestive of inflammatory bowel disease.
基金Supported by a grant from the Major Science and Technology Project of "National Significant New Drug Creation" (No. 2008ZX09312-002)
文摘Objective： Male breast cancer （MBC） is a rare disease, and studies to compare the prognosis between the MBC and female breast cancer （FBC） available now were case-control studies and population-based studies, however, with controversial outcomes. To further investigate whether sex affects the prognosis of breast cancer, we performed a meta-analysis based on all the peered papers. Methods： The PubMed database was screened. Subsequently, the hazard ratios （HRs） for overall survival （OS） and disease special survival （DSS）, were pooled using the Review Manager 5.0 package. Results： This study comprised of 254 MBC and 733 FBC patients enrolled in six case-control studies. There was no statistically significant heterogeneity among the trials for either outcome variable. The pooled HR showed that there was no significant difference in 5-year or 10-year DSS （HR： 1.25, 95% CI： 0.76-2.08; HR： 1.04, 95% CI： 0.68-1.5g） and 5-year or 10-year OS （HR： 0.76, 95% CI： 0.51-1.14; HR： 0.74, 95% CI： 0.54-1.02） between MBCs and FBCs. Conclusion： MBC and FBC with similar prognosis are found in this meta-analysis based on only case-control studies which matched main potential prognostic factors such as age, clinical stage, and time at diagnosis.
文摘Introduction:Rectal prolapse is a condition that occurs infrequently in men and there is little literature guiding treatment in this population.The purpose of this study was to evaluate the surgical approach and outcomes of rectal-prolapse repair in men.Methods:A retrospective multicenter review was conducted of consecutive men who underwent rectal-prolapse repair between 2004 and 2014.Surgical approaches and outcomes,including erectile function and fecal continence,were evaluated.Results:During the study period,58 men underwent rectal-prolapse repair and the mean age of repair was 52.7624.1 years.The mean follow-up was 13.2 months(range,0.5–117 months).The majority of patients underwent endoscopic evaluation(78%),but few patients underwent anal manometry(16%),defecography(9%)or ultrasound(3%).Ten patients(17%)underwent biofeedback/pelvic-floor physical therapy prior to repair.Nineteen patients(33%)underwent a perineal approach(most were perineal proctosigmoidectomy).Thirty-nine patients(67%)underwent repair using an abdominal approach(all were suture rectopexy)and,of these,77%were completed using a minimally invasive technique.The overall complication rate was 26%including urinary retention(16%),which was more common in patients undergoing the perineal approach(32%vs.8%,P=0.028),urinary-tract infection(7%)and wound infection(3%).The overall recurrence rate was 9%,with no difference between abdominal and perineal approaches.Information on sexual function was missing in the majority of patients both before and after surgery(76%and 78%,respectively).Conclusion:Rectal-prolapse repair in men is safe and has a low recurrence rate;however,sexual function was poorly recorded across all institutions.Further studies are needed to evaluate to best approach to and functional outcomes of rectal-prolapse repair in men.
