Objective： The aim of this study was to compare the effect of 131I therapy of different clinical stages in postopera- tive patients with papillary thyroid carcinoma （PTC）. Methods： Eighty-seven PTC patients after ...Objective： The aim of this study was to compare the effect of 131I therapy of different clinical stages in postopera- tive patients with papillary thyroid carcinoma （PTC）. Methods： Eighty-seven PTC patients after surgery ablated with high doses of 131I from 2004 to 2010 were retrospectively reviewed. The efficacy of 131I therapy was assessed by three diagnostics that serum thyroglobulin （Tg） was normal or significantly reduced, 131I whole body scan （131I-WBS） was negative or the metas- tases shrank or the number of them decreased and new metastases was not found in cervical ultrasound examination. The x2 test was used to analyze 3 factors which might affect the therapeutic efficacy of 131I in patients of different clinical period, including different surgical ways （total or subtotal thyroidectomy along with half or double sides neck lymph node dissection）, age （〈 45 years and 〉 45 years） and ablative 131I dose. Results： Of 87 patients, the effective rate of 46 patients I stage was 89.13% （41）; the effective rate of 22 cases III stage was 77.27% （17）; the effective rate of 19 cases IV stage was 36.84% （7）. The corresponding intra-groups statistical difference of 3 stages was significant by x2 test （x2 = 1.72, 19.03, 6.87; P 〉 0.25, P 〈 0.005, P 〈 0.01）. The effective rate was 91.67% （44） in 48 cases undergoing total thyroidectomy; the effective rate was 53.85% （21） in 39 patients undergoing subtotal thyroidectomy. There was a significant difference between the two groups above by x2 test （x2 = 16.291; P 〈 0.005）. Conclusion： The efficacy of 131I ablation of stage I and stage III in postoperative PTC patients was almost alike, while the efficacy of stage IV descended markedly. The results was mainly determined by residual thyroid tissue size because of different surgical modus.展开更多
OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with i...OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with insomnia were randomly assigned to a placebo group, a low-dose (10 mL/day), or a high-dose (20 mL/day) mistura group. Efficacy was assessed by using the sleep dysfunction rating scale (SDRS) and Clinical Global Impression-Improvement (CGI-I) scores. Safety and tolerability assessments included emergent adverse events, laboratory tests, and electrocardiograms. RESULTS: Total SDRS scores decreased in all three groups, and there were significant differences between the placebo group and the lowand high-dose mistura groups (P=0.000). CGI-I ratings in the lowand high-dose mistura groups were sig-nificantly better than that of the placebo group (P= 0.000). Incidences of rebound insomnia were similar in all three groups (placebo group: 6.94% , low-dose mistura group: 12.99% , and high-dose mistura group: 10.96% ; P=0.475). The efficacy of Huadananshen mistura in the lowor high-dose group was significantly better than that of the placebo group (P=0.000), but with no significant difference found between the lowand high-dose mistura groups (P=0.887). The rates of adverse events were similar in the three groups (placebo 2.44% , low-dose mistura 0%, and high-dose mistura 5%; P=0.088). CONCLUSION: Huadananshen mistura is an effective and generally well-tolerated hypnotic medicine for the treatment of Chinese patients with insomnia.展开更多
OBJECTIVE:To systematically evaluate the curative effect of acupuncture on post-stroke depression(PSD).METHODS:The internet was used to retrieve the Wanfang Medical Data System,Chinese Periodical Net,the Weipu Informa...OBJECTIVE:To systematically evaluate the curative effect of acupuncture on post-stroke depression(PSD).METHODS:The internet was used to retrieve the Wanfang Medical Data System,Chinese Periodical Net,the Weipu Information Resources System,PubMed and the Cochrane Library Database.Relevant articles,up to September 2010,were manually retrieved.These papers included studies that had performed random and semi-random control trials for the use of acupuncture to treat PSD.Fifteen random control tests involving 1096 patients were included in this study and individual cases,interventional measures and curative effects were extracted from this research.Grade methodological quality evaluation and meta-analysis were performed on these studies.RESULTS:Comparison between the acupuncture group and the Western medicine group for the curative rate on PSD revealed an OR of 1.48,95% CI = [1.11 1.97] and P=0.008.Comparison of obviously effective rate shows that OR=1.39,95% CI=[1.08 1.80] and P=0.01.Comparison of effective rate showsthatOR=0.83,95%CI=[0.631.09]andP=0.18.CONCLUSION:Comparison between the acupuncture group and Western medicine group in treating PSD revealed that there is a statistical difference in curative rate and remarkably effective rate,but no difference in effective rate.展开更多
Objective: To observe the therapeutic effects of peridural injection of Mailuoning Compound Liquor (脉络宁复合液) for prolapse of lumbar intervertebral disc (PLID). Methods: Peridural injection of Mailuoning Compound ...Objective: To observe the therapeutic effects of peridural injection of Mailuoning Compound Liquor (脉络宁复合液) for prolapse of lumbar intervertebral disc (PLID). Methods: Peridural injection of Mailuoning Compound Liquor (MCL) was given to 100 cases of PLID, once a week, 4 sessions constituting a therapeutic course. By adopting the scoring method, observations were carried out on the total therapeutic effect and changes in the 13 items of the symptoms and signs. Results: After treatment, the JOA scores in this series of patients were markedly enhanced as compared with the scores before treatment, showing significant differences in the paired t test (P<0.05). The sum of the excellent and good rates was 64%, and the total effective rate was 97%. All the scores in the 13 items under observation were significantly raised as compared with the scores before treatment (P<0.05). Conclusion: Peridural injection of MCL is an effective and safe therapy for PLID, and with shorter treating course, quicker therapeutic effects, and less suffering for the patients.展开更多
The empirical likelihood approach is suggested to the pretest-posttest trial based on the constrains, which we construct to summarize all the given information. The author obtains a log-empirical likelihood ratio test...The empirical likelihood approach is suggested to the pretest-posttest trial based on the constrains, which we construct to summarize all the given information. The author obtains a log-empirical likelihood ratio test statistic that has a standard chi-squared limiting distribution. Thus, in making inferences, there is no need to estimate variance explicitly, and inferential procedures are easier to implement. Simulation results show that the approach of this paper is more efficient compared with ANCOVA II due to the sufficient and appropriate use of information.展开更多
文摘Objective： The aim of this study was to compare the effect of 131I therapy of different clinical stages in postopera- tive patients with papillary thyroid carcinoma （PTC）. Methods： Eighty-seven PTC patients after surgery ablated with high doses of 131I from 2004 to 2010 were retrospectively reviewed. The efficacy of 131I therapy was assessed by three diagnostics that serum thyroglobulin （Tg） was normal or significantly reduced, 131I whole body scan （131I-WBS） was negative or the metas- tases shrank or the number of them decreased and new metastases was not found in cervical ultrasound examination. The x2 test was used to analyze 3 factors which might affect the therapeutic efficacy of 131I in patients of different clinical period, including different surgical ways （total or subtotal thyroidectomy along with half or double sides neck lymph node dissection）, age （〈 45 years and 〉 45 years） and ablative 131I dose. Results： Of 87 patients, the effective rate of 46 patients I stage was 89.13% （41）; the effective rate of 22 cases III stage was 77.27% （17）; the effective rate of 19 cases IV stage was 36.84% （7）. The corresponding intra-groups statistical difference of 3 stages was significant by x2 test （x2 = 1.72, 19.03, 6.87; P 〉 0.25, P 〈 0.005, P 〈 0.01）. The effective rate was 91.67% （44） in 48 cases undergoing total thyroidectomy; the effective rate was 53.85% （21） in 39 patients undergoing subtotal thyroidectomy. There was a significant difference between the two groups above by x2 test （x2 = 16.291; P 〈 0.005）. Conclusion： The efficacy of 131I ablation of stage I and stage III in postoperative PTC patients was almost alike, while the efficacy of stage IV descended markedly. The results was mainly determined by residual thyroid tissue size because of different surgical modus.
基金Supported by the Grants from National Major Project for IND(2012ZX09303-003)Shanghai Health Talent Professional Project(XBR2011049)
文摘OBJECTIVE: To evaluate the effect of Huadananshen mistura in clinical treatment of Chinese patients with insomnia. METHODS: In this randomized, double-blind, placebo-controlled, multi-center study, 244 patients with insomnia were randomly assigned to a placebo group, a low-dose (10 mL/day), or a high-dose (20 mL/day) mistura group. Efficacy was assessed by using the sleep dysfunction rating scale (SDRS) and Clinical Global Impression-Improvement (CGI-I) scores. Safety and tolerability assessments included emergent adverse events, laboratory tests, and electrocardiograms. RESULTS: Total SDRS scores decreased in all three groups, and there were significant differences between the placebo group and the lowand high-dose mistura groups (P=0.000). CGI-I ratings in the lowand high-dose mistura groups were sig-nificantly better than that of the placebo group (P= 0.000). Incidences of rebound insomnia were similar in all three groups (placebo group: 6.94% , low-dose mistura group: 12.99% , and high-dose mistura group: 10.96% ; P=0.475). The efficacy of Huadananshen mistura in the lowor high-dose group was significantly better than that of the placebo group (P=0.000), but with no significant difference found between the lowand high-dose mistura groups (P=0.887). The rates of adverse events were similar in the three groups (placebo 2.44% , low-dose mistura 0%, and high-dose mistura 5%; P=0.088). CONCLUSION: Huadananshen mistura is an effective and generally well-tolerated hypnotic medicine for the treatment of Chinese patients with insomnia.
基金Supported by Specific scientific research fund for doctoral points of higher learning institutions of Education Ministry,20094425110005State natural science fund,30772828+1 种基金Guangdong provincial natural science fund,07004846Project in sci-tech plan of sci-tech department of Guangdong province,2008B030301206
文摘OBJECTIVE:To systematically evaluate the curative effect of acupuncture on post-stroke depression(PSD).METHODS:The internet was used to retrieve the Wanfang Medical Data System,Chinese Periodical Net,the Weipu Information Resources System,PubMed and the Cochrane Library Database.Relevant articles,up to September 2010,were manually retrieved.These papers included studies that had performed random and semi-random control trials for the use of acupuncture to treat PSD.Fifteen random control tests involving 1096 patients were included in this study and individual cases,interventional measures and curative effects were extracted from this research.Grade methodological quality evaluation and meta-analysis were performed on these studies.RESULTS:Comparison between the acupuncture group and the Western medicine group for the curative rate on PSD revealed an OR of 1.48,95% CI = [1.11 1.97] and P=0.008.Comparison of obviously effective rate shows that OR=1.39,95% CI=[1.08 1.80] and P=0.01.Comparison of effective rate showsthatOR=0.83,95%CI=[0.631.09]andP=0.18.CONCLUSION:Comparison between the acupuncture group and Western medicine group in treating PSD revealed that there is a statistical difference in curative rate and remarkably effective rate,but no difference in effective rate.
文摘Objective: To observe the therapeutic effects of peridural injection of Mailuoning Compound Liquor (脉络宁复合液) for prolapse of lumbar intervertebral disc (PLID). Methods: Peridural injection of Mailuoning Compound Liquor (MCL) was given to 100 cases of PLID, once a week, 4 sessions constituting a therapeutic course. By adopting the scoring method, observations were carried out on the total therapeutic effect and changes in the 13 items of the symptoms and signs. Results: After treatment, the JOA scores in this series of patients were markedly enhanced as compared with the scores before treatment, showing significant differences in the paired t test (P<0.05). The sum of the excellent and good rates was 64%, and the total effective rate was 97%. All the scores in the 13 items under observation were significantly raised as compared with the scores before treatment (P<0.05). Conclusion: Peridural injection of MCL is an effective and safe therapy for PLID, and with shorter treating course, quicker therapeutic effects, and less suffering for the patients.
基金Project supported by the National Natural Science Foundation of China(No.10971033)
文摘The empirical likelihood approach is suggested to the pretest-posttest trial based on the constrains, which we construct to summarize all the given information. The author obtains a log-empirical likelihood ratio test statistic that has a standard chi-squared limiting distribution. Thus, in making inferences, there is no need to estimate variance explicitly, and inferential procedures are easier to implement. Simulation results show that the approach of this paper is more efficient compared with ANCOVA II due to the sufficient and appropriate use of information.
