疏肝健脾法治疗肝郁脾虚型卒中后抑郁的疗效Meta分析

目的评价疏肝健脾法治疗肝郁脾虚型卒中后抑郁的临床疗效。方法电子系统及人工检索PubMed、The Cochrane Library、EMbase、CNKI、VIP、WanFang Data和CBM数据库,时限为从建库至2018年9月。收集疏肝健脾法治疗肝郁脾虚型卒中后抑郁的随机对照试验(RCTs),采用Cochrane Reviewer’s Handbook 5.1.0中的方法进行文献质量评价和资料分析,运用Rev Man 5.3软件对纳入的RCT研究进行Meta分析,分类和连续型变量分别用相对危险度(RR)和标准化均数差(SMD)或均数差(MD)作为合并效应量。结果共纳入15个RCTs,包括1099例患者。Meta分析结果示,汉密尔顿抑郁量表(HAMD)有效率[RR=1.19,95%CI(1.12,1.26),P<0.00001],HAMD评分[SMD=-0.79,95%CI(-1.12,-0.46),P<0.00001],中医证候有效率[RR=1.35,95%CI(1.15,1.59),P=0.0002],中医证候总积分[MD=-3.96,95%CI(-6.42,-1.50),P=0.002]、社会功能缺陷量表(SDSS)评分[MD=-2.57,95%CI(-4.29,-0.84),P=0.004]。结论疏肝健脾法治疗肝郁脾虚型卒中抑郁的临床疗效较对照组存在明显优势。

中西医联合治疗儿童变应性鼻炎疗效的Meta分析

目的:系统性评价中西医联合治疗儿童变应性鼻炎的疗效及安全性。方法:通过关键词检索PubMed、Embase、Cochrane、CBM(中国生物医学文献数据库)、CNKI(中国知网数据库)、VIP(维普数据库)、WanFang(万方数据库)等中外数据库,查阅中西医联合治疗儿童变应性鼻炎的随机对照试验,检索时限为2011年1月1日至2021年10月31日,运用Stata 16.0软件进行Meta分析。结果:最终纳入18项随机对照试验,共计1865例患者,其中治疗组938例,对照组927例。Meta分析结果显示:中西医联合治疗儿童变应性鼻炎的总有效率提高15%(RD=0.15,95%CI:0.12~0.19,P<0.05),以及改善鼻塞、流涕方面均优于单纯西药(P<0.05)。结论:中西医联合治疗能有效提高儿童变应性鼻炎的临床治疗效果。

温肾中药复方对慢性阻塞性肺疾病急性加重期合并呼吸衰竭临床疗效的Meta分析

目的:系统评价温肾中药复方对慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭临床疗效。方法:通过检索2008—2018年PubMed、The Cochrane Library、CBM、EMbase、VIP、CNKI和WanFang Data数据库公开发表的温肾中药复方对AECOPD合并呼吸衰竭的随机对照试验(RCT)研究。由2位研究者独立进行文献筛选、资料提取,并对纳入研究的偏倚风险评价后,运用软件Rev Man 5.3进行Meta分析。结果:经过逐步筛选,最终纳入9个随机对照试验,共742例AECOPD合并呼吸衰竭患者,Meta分析结果显示:①在临床疗效显效率方面,温肾中药复方结合西医常规治疗AECOPD合并呼吸衰竭的总体疗效显著优于西医常规治疗[RR=1.35,95%CI(1.16,1.57),P=0.0001]。②在增加患者动脉血气氧分压和降低二氧化碳潴留情况方面,温肾中药复方结合西医常规治疗明显优于西医常规治疗[二氧化碳分压组:MD=-7.38,95%CI(-9.96,-4.80),P<0.00001;氧分压组:MD=9.05,95%CI(6.36,11.74),P<0.00001]。③在缩短机械通气时间方面,温肾中药复方治疗组要低于西医常规治疗组[MD=-2.73,95%CI(-3.57,-1.89),P<0.00001]。结论:温肾中药复方对AECOPD合并呼吸衰竭的治疗具有较好的临床效果,但因纳入文献样本有限以及文献质量不高,仍需高质量的大样本多中心随机对照研究来进一步验证。

左旋肉碱治疗胰岛素抵抗的系统评价和Meta分析

目的:评价左旋肉碱治疗胰岛素抵抗的疗效。方法:检索Cochrane、Pub Med、EMBASE,纳入左旋肉碱治疗胰岛素抵抗的相关研究,对纳入的研究进行系统评价,同时用Stata 12.0软件进行Meta分析。结果:共有5篇随机对照试验研究纳入,其中有631例患者,安慰剂组312例,左旋肉碱组319例,研究时间为4周到6个月。数据表明左旋肉碱在治疗胰岛素抵抗的疗效有统计学意义(P<0.05),同时随着治疗时间的延长,P值逐渐变小。结论:左旋肉碱能够有效治疗胰岛素抵抗,此外,随着左旋肉碱的疗程延长其治疗效果越为明显。

中医药治疗慢性萎缩性胃炎伴异型增生疗效的系统评价

[目的]分析比较中医药治疗与西医治疗慢性萎缩性胃炎(chronic atrophic gastritis,CAG)伴异型增生的疗效和安全性。[方法]检索PubMed、Cochrane图书馆、万方和中国期刊网中的随机对照试验(randomized controlled trial,RCT)文献,根据纳入标准将论文纳入研究并提取纳入研究的特征信息,按治疗方法分为西医对照组和中医药治疗组。采用RevMan5.0软件进行数据分析,先后进行异质性检验,根据检验结果选择相应的效应模型。然后进行敏感性分析,并以漏斗图、Egger回归方程评定有无发表偏倚。[结果]6篇RCT文献纳入本研究,共有632例CAG伴异型增生的患者。研究表明,中医药治疗组的临床症状、胃镜改善及病理改善情况的总显效率及总有效率的优势比(OR)均高于西医对照组;漏斗图基本呈现下宽上窄、左右对称的倒漏斗形,Egger线性回归常数项检验表明无发表偏倚。[结论]中医药治疗CAG伴异型增生能有效改善本病临床症状、胃镜及病理情况,疗效优于西医对照组。

Meta-analysis of the efficacy and safety of Huanglian Wendan Decoction alone or combined with western medicine in treating insomnia caused by phlegm-heat internal disturbance

Objective To evaluate the efficacy and safety of Huanglian Wendan Decoction(黄连温胆汤,HLWDD)alone or combined with western medicine in treating insomnia caused by phlegm-heat internal disturbance in recent 10 years.Methods The randomized controlled trials of HLWDD alone or combined with western medicine in treating insomnia caused by phlegm-heat internal disturbance from January 1,2012 to April 1,2022 were searched in China National Knowledge Infrastructure(CNKI),China Science and Technology Journal Database(VIP),Wanfang Database,China BioMedical Literature Database(CBM),PubMed,Web of Science,Embase,and Cochrane Library databases.After being screening,the included literature was analyzed to evaluate the effective rate,Pittsburgh Sleep Quality Index(PSQI)score,traditional Chinese medicine(TCM)syndrome score,and adverse reactions of HLWDD on insomnia caused by phlegm-heat internal disturbance.The subgroup analyzed the effect of HLWDD after different treatment courses,and compared the therapeutic effects of HLWDD alone and HLWDD combined with western medicine.Results Twenty-seven randomized controlled trials were finally included,with a total of 2395 patients.The results of the meta-analysis showed that the curative effect of HLWDD alone or combined with the western medicine group was better than that of the western medicine group[RR=1.14,95%CI(1.06,1.22),P=0.000].The PSQI score[SMD=-0.31,95%CI(-0.42,-0.20),P=0.000],TCM syndrome score[SMD=-0.40,95%CI(-0.67,-0.12),P=0.005],and adverse reaction rate[RR=0.21,95%CI(0.15,0.29),P=0.000]of HLWDD alone or combined with western medicine group were significantly reduced compared with the western medicine group.The subgroup’s analysis showed that the curative effect of HLWDD alone or combined with western medicine group of 4 weeks treatment course was better than that of the western medicine group[RR=1.14,95%CI(1.03,1.26),P<0.05].The TCM syndrome score of HLWDD alone or combined with the western medicine group of 4 weeks treatment course decreased more obviously than that of the western medicine group[SMD=-0.60,95%CI(-0.96,-0.25),P<0.05].There were no significant differences between HLWDD alone or combined with western medicine group and western medicine group with different treatment courses based on PSQI score and adverse reaction rate.Based on the effective rate,the comparison between the HLWDD alone group and the western medicine group[RR=1.09,95%CI(1.00,-1.20)P<0.05],and between the HLWDD combined with western medicine group and the western medicine group[RR=1.15,95%CI(1.03,1.29),P<0.05]was the same.PSQI score[SMD=-0.44,95%CI(-0.59,-0.30),P<0.05]and TCM syndrome score[SMD=-1.10,95%CI(-1.59,-0.61),P<0.05]of HLWDD combined with western medicine group were significantly lower than those of the western medicine group.There were no significant differences of adverse reaction rate between HLWDD alone group[RR=0.08,95%CI(0.04,0.17),P<0.05]and HLWDD combined with western medicine group[RR=0.36,95%CI(0.24,0.53),P<0.05].Conclusion HLWDD alone or combined with western medicine is an effective treatment for insomnia caused by phlegm-heat internal disturbance,which has a high effective rate,significantly reduced PSQI score and TCM syndrome score,and favorable safety.The best course of treatment is 4 weeks.

The effect of Supplementing Qi and Nourishing Yin combined with chemotherapy for lung cancer： a meta-analysis

Objective： To evaluate whether herbs of supplementing Qi and nourishing Yin combined with chemotherapy （versus chemotherapy alone） improve survival, increase tumor response, improve performance status or reduce chemotherapy toxicity in patients with lung cancer. Methods： Searching the randomized controlled trials （RCT） studies from the databases （China HowNet database, Wan Fang database, VIP database, Master Thesis and Pubmed） between January 2013 and January 2017. RevMan 5.3 software was used to evaluate the quality of these collected papers. Results： Of 48 potentially relevant publications, 10 randomized studies representing 691 patients met inclusion criteria with 369 cases in the supplementing Qi and nourishing Yin plus Chemotherapy group （Herbs ＋ Chem group） and 322 cases in Chemotherapy group （Chem only group）. There were significant differences between Herbs ＋ Chem group and Chem only group in improving the treatment efficacy and reducing the side effects of chemotherapy （P 〈 0.001 for all）. There were also significant differences between the two groups in tumor response and quality of life （P 〈 0.001 for all）. Conclusion： Herbs of supplementing Qi and nourishing Yin may increase chemotherapy effectiveness, reduce chemotherapy toxicity and improve the quality of life of patients with lung cancer when combined with chemotherapy.

Salvage liver transplantation in the treatment of hepatocellular carcinoma:A Meta-analysis

AIM:To evaluate survival and recurrence after salvage liver transplantation(SLT) for the treatment of hepatocellular carcinoma(HCC) compared with primary liver transplantation(PLT) using a meta-analysis.METHODS:Literature on SLT versus PLT for the treatment of HCC published between 1966 and July 2011 was retrieved.A meta-analysis was conducted to estimate pooled survival and disease-free rates.A fixed or random-effect model was established to collect the data.RESULTS:The differences in overall survival and disease-free survival rates at 1-year,3-year and 5-year survival rates were not statistically significant between SLT group and PLT group(P > 0.05).After stratifying the various studies by donor source and Milan criteria,we found that:(1) Living donor liver transplantation recipients had significantly higher 1-year survival rate,lower 3-year and 5-year survival rates compared with deceased-donor liver transplantation(DDLT) recipients.And in DDLT recipients they had better 1-year and 5-year disease-free survival rate in SLT group;and(2) No difference was seen in 1-year,3-year and 5-year survival rates between two groups who beyond Milan criteria at the time of liver transplantation.CONCLUSION:SLT can be effectively performed for patients with recurrence or deterioration of liver function after hepatectomy for HCC.It does not increase the perioperative mortality and has a similar long-term survival rates compared to PLT.

Effects of telbivudine and entecavir for HBeAg-positive chronic hepatitis B: A meta-analysis

AIM:To compare the effects of telbivudine (LDT) and entecavir (ETV) in treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B by meta-analysis. METHODS:We conducted a literature search using PubMed, MEDLINE, EMBASE, the China National Knowledge Infrastructure, the VIP database, the Wanfang database and the Cochrane Controlled Trial Register for all relevant articles published before April 1, 2012. Randomized controlled trials (RCTs) comparing LDT with ETV for treatment of HBeAg-positive chronic hepatitis B were included. The data was analyzed with Review Manager Software 5.0. We used relative risk (RR) as an effect measure, and reported its 95% CI. Meta-analysis was performed using either a fixedeffect or random-effect model, based on the absence or presence of significant heterogeneity. Two reviewers assessed the risk of bias and extracted data indepen- dently and in duplicate. The analysis was executed using the main outcome parameters including hepatitis B virus (HBV) DNA undetectability, alanine aminotransferase (ALT) normalization, HBeAg loss, HBeAg seroconversion, drug-resistance, and adverse reactions. Meta-analysis of the included trials and subgroup analyses were conducted to examine the association between pre-specified characteristics with the therapeutic effects of the two agents. RESULTS:Thirteen eligible trials (3925 patients in total) were included and evaluated for methodological quality and heterogeneity. In various treatment durations of 4 wk, 8 wk, 12 wk, 24 wk, 36 wk, 48 wk, 52 wk, 60 wk and 72 wk, the rates of HBV DNA undetectability and ALT normalization in the two groups were similar, without statistical significance. At 4 wk and 8 wk of the treatment, no statistical differences were found in the rate of HBeAg loss between the two groups, while the rate in the LDT group was higher than in the ETV group at 12 wk, 24 wk, 48 wk and 52 wk, respectively (RR 2.28, 95% CI 1.16, 7.03, P = 0.02; RR 1.45, 95% CI 1.16, 1.82, P = 0.001; RR 1.45, 95% CI 1.11, 1.89, P = 0.006; and RR 1.86, 95% CI 1.04, 3.32, P = 0.04). At 4 wk, 8 wk, 60 wk and 72 wk of the treatment, there were no significant differences in the rate of HBeAg seroconversion between the two groups, while at 12 wk, 24 wk, 48 wk and 52 wk, the rate in the LDT group was higher than in the ETV group (RR 2.10, 95% CI 1.36, 3.24, P = 0.0008; RR 1.71, 95% CI 1.29, 2.28, P = 0.0002; RR 1.86, 95% CI 1.36, 2.54, P < 0.0001; and RR 1.87, 95% CI 1.21, 2.90, P = 0.005). The rate of drug-resistance was higher in the LDT group than in the ETV group (RR 3.76, 95% CI 1.28, 11.01, P = 0.02). In addition, no severe adverse drug reactions were observed in the two groups. And the rate of increased creatine kinase in the LDT group was higher than in the ETV group (RR 5.58, 95% CI 2.22, 13.98, P = 0.0002). CONCLUSION:LDT and ETV have similar virological and biomedical responses, and both are safe and well tolerated. However, LDT has better serological response and higher drug-resistance.

国内双歧杆菌制剂预防小儿继发性腹泻临床疗效的Meta分析

目的系统评价国内双歧杆菌制剂临床预防小儿继发性腹泻的效果。方法按照系统评价的要求检索CBMd isc、VIP、CNK I以及万方数据库等,获得18篇符合纳入标准的文献,共计患儿4050例,对其进行M eta分析,并评价M eta分析结果的稳定性和发表偏倚。结果异质性检验χ^2=34.60,P=0.007〈0.05,采用随机效应模型进行M eta分析,合并RR=0.41,95%C I为0.35～0.49,总体效应检验,Z=10.39,P〈0.00001,差异具有非常显著性,固定效应模型RR值和95%C I与随机效应模型完全一致,剔除小样本报道后的合并RR=0.42,95%C I为0.35～0.50,与剔除前的结果基本一致,且本研究的发表偏倚得到了很好地控制。结论从现有的临床证据来看,双歧杆菌制剂能降低小儿继发性腹泻的发生率,对预防小儿继发性腹泻起到了满意的效果。

Therapeutic Effect and Safety of Ustekinumab for Plaque Psoriasis: A Meta-analysis

Objective To evaluate the efficacy and safety of ustekinumab in the therapy of plaque psoriasis. Methods Literatures published up to November 2013 were collected from Cochrane library, MEDLINE, and PubMed which were related with ustekinumab for plaque psoriasis. The efficacy was estimated using relative risk of Psoriasis Area and Severity Index （PASI） 75 response rate at the week 12 endpoint in clinical trials, and adverse effects were also analyzed. Meta-analysis was carried out by using Review Manager 5.1. Results Six randomized control trials consistent with the inclusion criteria were selected and reviewed. Ustekinumab 45 mg group and 90 mg group could get better therapeutic effect compared with the placebo group （all P〈0.00001）. Furthermore, ustekinumab 90 mg group was more effective than ustekinumab 45 mg group （P=0.01）. Adverse effects in the 6 trials were mentioned including headache, upper respiratory tract infection, nasopharyngtis, infection, serious infection, cardiovascular events, and malignant tumors. There were no statistically significant differences of these adverse effects among three groups （all P〉0.0S）, except that infection rate in ustekinumab 45 mg group was higher than the placebo group （P=0.02）. Conclusions Ustekinumab is an effective and safe therapeutic method for plaque psoriasis. However, further longer time analysis of safety is needed.

盐酸多奈哌齐治疗血管性痴呆的系统评价

目的评价盐酸多奈哌齐治疗血管性痴呆(VD)的临床效果和安全性。方法应用Meta分析方法对11项研究盐酸多奈哌齐治疗VD的自身前后对照试验进行再分析,评价其综合显著性差异和效应大小。结果①盐酸多奈哌齐治疗前后的MMSE评分比较:综合检验Z=14.68,自由度22,P<0.0005;ES:d=1.097。②盐酸多奈哌齐治疗前后的ADL评分比较:综合检验Z=8.30,自由度16,P<0.0005;ES:d=0.71。③11项研究中报道的药物不良反应的发生率为0.29%￣7.1%,主要为胆碱能兴奋的表现。结论盐酸多奈哌齐是一种治疗VD安全、有效的药物。

Meta analysis of the effect of distal or local point selection on acupuncture efficacy

To evaluate the effect of distal point selection, local point selection, and distal-local point selection on acupuncture efficacy. Methods： According to the requirements of evidence-based medicine（EBM）, the literature on acupuncture with distal and local point selection in recent 20 years included in domestic and overseas medical databases was retrieved, and meta-analysis of the included articles was carried out. Results： Thirty-two articles were included finally, totaling 2829 patients. The results of meta-analysis indicated that the curative effect of distal-local point combination was superior to that of simple distal point selection or local point selection during acupuncture–moxibustion treatment for diseases, and there was no obvious difference in the curative effect between simple distal point selection and local point selection. According to the comprehensive analysis of 18 included articles, the difference in total effective rate between distal point selection and local point selection was not statistically significant, i.e. the curative effect of distal point selection and local point selection was equivalent [OR=0.83,95%CI（0.83,1.18）, Z=1.04, P0.01]. According to the comprehensive analysis of 20 included articles, the difference in total effective rate between local point selection and distal-local point selection was statistically significant, and the results indicated that the curative effect of distal-local point selection was superior to that of local point selection [OR=0.32, 95%CI（0.23,0.44）, Z=6.90, P0.01]. According to the comprehensive analysis of 8 included articles, the difference in total effective rate between distal point selection and distal-local point selection was statistically significant, and the results indicated that the curative effect of distal-local point selection was superior to that of distal point selection [OR=0.20,95%CI（0.10,0.40）, Z=4.50, P0.01]. In addition, the analysis of publication bias of this study indicated that publication bias might exist. Since the quality of included articles was generally lower, the above conclusion still needed to be supported by more evidence-based medicine proofs with high quality. Conclusion： The curative effect of distal-local point combination was superior to that of simple distal point selection or local point selection during acupuncture treatment for diseases, and there was no obvious difference in the curative effect between simple distal point selection and local point selection.

Systematic evaluation on the clinical efficacy of acupoint stimulation therapy for treatment of premature ovarian insufficiency on the basis of network Meta-analysis

Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases as Pub Med, Embase, Cochrane Library, web of science, Chinese biomedicine database（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang and VIP in order to collect the randomized controlled trials（RCT） concerning acupoint stimulation therapy for treatment of POI. Software R 3.40 and stata 14.0 were used for Meta-analysis and network Meta-analysis, and Rev Man 5.3 was used for plotting the risk bias diagrams. Results Fortythree RCTs were included in total, involving 3046 POI patients and 18 acupoint stimulation therapies and comprehensive therapies. Metaanalysis showed：（1） The curative effects of acupoint stimulation therapy（RR=1.25, 95%CI [1.07,1.45]）, acupoint stimulation therapy＋Chinese herbal medicine（RR=1.25, 95%CI [1.18,1.32]） and acupoint stimulation therapy＋ hormone replacement therapy（HRT）（RR=1.20, 95%CI [1.12,1.29]） were all superior to that of HRT, indicating that the differences were statistically significant（Z=2.90, P=0.04; Z=7.56, P〈0.000 01; Z=4.06, P〈0.000 01）.（2） Compared with HRT, the occurrence rate of adverse effect of acupoint stimulation therapy was lower, and the safety was superior to that of HRT（RR=0.18, 95%CI [0.08,0.41]）, indicating that the differences were statistically significant（Z=4.08, P〈0.000 1）. Forty-two direct comparisons and 110 indirect comparisons were generated according to network Meta-analysis, among which, 38 comparisons were statistically significant. Network Metaanalysis results with HRT as control showed： the therapeutic measures ranking top 3 according to the curative effect sequence were catgut embedment in acupoint, moxibustion and warming-needle moxibustion, successively, and all the 3 measures were monotherapies without reflecting the advantages of comprehensive therapy. HRT ranked 17 th among the 18 included therapeutic measures. Conclusion On the basis of current evidences, acupoint stimulation therapy has a better clinical efficacy and safety for treatment of POI when compared with HRT. The acupoint stimulation therapies ranking the top 3 have more significant curative effects, but the long-term efficacy and the effect on the ovarian function still need to be further explored. In addition, the conclusion of this study still needs to be verified through a large number of RCTs with reasonable designs and appropriate methods.

Effect of Aidi injection plus chemotherapy on gastric carcinoma:a Meta-analysis of randomized controlled trials

OBJECTIVE: To conduct a Meta-analysis of studies on the effect of Aidi injectioncombined with chemotherapy versus chemotherapy alone in the treatment of gastric cancer(GC).METHODS: Nine electronic databases and six gray literature databases were comprehensively searcheduntil April 20,2013. Two reviewers independently selected and assessed included trialsaccording to the inclusion and exclusion criteria. The risk of bias tool from the Cochrane Handbook version 5.1.0was used to assess trial quality. All calculations were performed using Review Manager 5.0.RESULTS: Thirty-two studies including 1927 participants met the inclusion criteria,most of which were low quality. Compared with chemotherapy alone,Aidi injection plusthe same chemotherapy significantly improved the effective rate [OR = 1.52,95% CI(1.24,1.86),P < 0.0001],clinical beneficial rate [OR = 1.77,95% CI(1.33,2.36),P < 0.0001],and quality of life [OR = 3.02,95% CI(2.39,3.82),P <0.000 01]. There was a significant improvement in nausea and vomiting incidence [OR = 0.34,95%CI(0.24,0.47),P < 0.000 01],diarrhea [OR = 0.47,95%CI(0.33,0.69),P < 0.000 01],leukopenia( 3,0.51),P = 0.05],hemⅢ-ogⅣ)[OR = 0.34,95%CI(0.2lobin decrease(thromⅢ-boⅣ) [OR = 0.42,95%CI(0.18-1.00),P = 0.05],cytopenia(4],and Ⅲ-damⅣ) [OR = 0.46,95%CI(0.22,0.96),P = 0.0age to liver function [OR = 0.36,95%CI(0.24,0.54),P < 0.000 01].CONCLUSION: Aidi injection combined with chemotherapy significantly improved the clinical effect of chemotherapy,reducing the incidence of adverse events. Use of the CONSORT statement for randomized controlled trials is recommended for stricter reporting.

Meta analysis of the curative effect of acupuncture on post-stroke depression

OBJECTIVE:To systematically evaluate the curative effect of acupuncture on post-stroke depression(PSD).METHODS:The internet was used to retrieve the Wanfang Medical Data System,Chinese Periodical Net,the Weipu Information Resources System,PubMed and the Cochrane Library Database.Relevant articles,up to September 2010,were manually retrieved.These papers included studies that had performed random and semi-random control trials for the use of acupuncture to treat PSD.Fifteen random control tests involving 1096 patients were included in this study and individual cases,interventional measures and curative effects were extracted from this research.Grade methodological quality evaluation and meta-analysis were performed on these studies.RESULTS:Comparison between the acupuncture group and the Western medicine group for the curative rate on PSD revealed an OR of 1.48,95% CI = [1.11 1.97] and P=0.008.Comparison of obviously effective rate shows that OR=1.39,95% CI=[1.08 1.80] and P=0.01.Comparison of effective rate showsthatOR=0.83,95%CI=[0.631.09]andP=0.18.CONCLUSION:Comparison between the acupuncture group and Western medicine group in treating PSD revealed that there is a statistical difference in curative rate and remarkably effective rate,but no difference in effective rate.

Effect of Tianshu capsule in treatment of migraine:a meta-analysi of randomized control trials

OBJECTIVE： To review the efficacy of Tianshu capsule in the treatment of migraine. METHODS： Retrieving papers from Pubmed, cochrane central register of controlled trials （CENTRAL）, Weipu database （VIP）, China biology medicine （CBM）, China national knowledge infrastructure （CNKI）, and Wanfang Data. Two reviewers retrieved and extracted the information indepen- dently. Retrieval time scale is up to August 2012.Software Review Manager 5.1 was used for analysis RESULTS： A total of 10 studies including 937 mi- graine patients. The merged data shows Tianshu capsule had a higher effective rate in treating mi- graine, and there is no significant heterogeneity between Tianshu capsule group and control group （x2=6.33, dr-=9, P=0.71, F=0%）, OR=4.18 [95%0 （2.93,5.95）]. Tianshu capsule alone compared to conventional therapy also showed advantages, and there was low heterogeneity （X2=4.53, dr=3, P=0.21, 12 = 34%）, OR=3.95 [95% CI （2.32, 6.72）]. Meta-analysis results show that clinical efficacy of Tianshu capsule was better than that of the control group in the treatment of migraine and there was a signifi- cant difference （P〈0.000 01）. CONCLUSION： Tianshu capsule had better efficacy in the treatment of migraine with fewer adverse effects.

Electroacupuncture at facial acupoints combined with electrical stimulation on the auricular vagus nerve points for 60 cases of chloasma

Objective： To observe the clinical efficacy of electroacupuncture at facial acupoints combined with electrical stimulation on the auricular vagus nerve points for treatment of chloasma.Methods： Sixty patients with chloasma were selected. According to acupoint selection along facial nerve trunk initially created by professor Gao Wei-bin, Yifeng（翳风TE 17）, Shangguan（上关GB 3） Sizhukong（丝竹空 TE 23）,temporal branches, Xiaguan（下关 ST 7） Sibai（四白 ST 2）,zygomatic branches, Qianzheng（牵正）Quanliao（颧髎 SI 18）,zygomatic branches, Jiache（颊车 ST 6） Chengjiang（承浆 CV 24）,buccal branches, and Hegu（合谷 LI 4）. The auricular vagus nerve acupoints was added additionally（two distribution points in each cavity of auricular concha were selected）. Electroacupuncture was conducted for30 min/time, once a day, and 6 times/week. One day was free from treatment between 2 weeks. Treatment for 4 weeks was 1 course of treatment, and the effect was observed after 1 course.Results： Cured： 39 cases, markedly effective： 13 cases, effective： 6 cases, ineffective： 3 cases. The cure rate was 65%, and the total effective rate was up to 95.0%.Conclusion： The curative effect of electroacupuncture at facial acupoints combined with electrical stimulation on the auricular vagus nerve points for treatment of chloasma was satisfactory.