Coccidiosis is a protozoan disease that seriously threatens the poultry in-dustry. At present, the prevention and treatment of chicken coccidiosis mainly rely on chemical drugs and coccidia live vaccine. However, drug...Coccidiosis is a protozoan disease that seriously threatens the poultry in-dustry. At present, the prevention and treatment of chicken coccidiosis mainly rely on chemical drugs and coccidia live vaccine. However, drug control has problems of drug resistance and drug residue, and the coccidia live vaccine has drawbacks of pathogenicity, high production costs and virulence enhancement. Instead, genetic en-gineering vaccine is easy to operate, stable, safe and efficient, so it has become a hot spot in the prevention of chicken coccidiosis. In this paper, the research status, immune mechanism, immune effect＇s influencing factors and cytokine adjuvant appli-cation of genetic engineering vaccine against chicken coccidiosis were reviewed to provide some reference for the research and application of chicken coccidiosis gene vaccine.展开更多
Network epidemiology has become a core framework for investigating the role of human contact patterns in the spreadingof infectious diseases.In network epidemiology,one represents the contact structure as a network of...Network epidemiology has become a core framework for investigating the role of human contact patterns in the spreadingof infectious diseases.In network epidemiology,one represents the contact structure as a network of nodes(individuals)connected bylinks(sometimes as a temporal network where the links are not continuously active)and the disease as a compartmental model(whereindividuals are assigned states with respect to the disease and follow certain transition rules between the states).In this paper,we discussfast algorithms for such simulations and also compare two commonly used versions,one where there is a constant recovery rate(the numberof individuals that stop being infectious per time is proportional to the number of such people);the other where the duration of the diseaseis constant.The results show that,for most practical purposes,these versions are qualitatively the same.展开更多
Objecrive: To investigate the relationship between apoptosis and proliferating cell nuclear antigcn (PCNA)expression of keratinocytes in Condylomata acuminata (CA). Methods: PCNA expression was observed byimmunohistoc...Objecrive: To investigate the relationship between apoptosis and proliferating cell nuclear antigcn (PCNA)expression of keratinocytes in Condylomata acuminata (CA). Methods: PCNA expression was observed byimmunohistochemistry technique (ABC method) in 51 CAspecimens and 1 normal specimens of foreskin or vaginalmucosae. 55 specimens (40 in the CA group and 15 in thecontrol group) were randomly sampled for in situ labelingof apoptotic cells using the TUNEL method. Results: Positive expression of PCNA in CA and controlgroups were 90.2% and 77.8%, respectively, and theproliferation index in CA group was significantly higherthan that in the control group (P<0.001). The positive rateof apoptosis was 42.5% in the LA group and 53.3% in thecontrol group, and there were no significant differences inthe apoptotic index and apoptosis-proliferation ratiobetween two groups (P>0.05). The proliferation indexshowed a significant negativc correlation with theapoptosis-proliferation ratio (r=-0.62, P=0.01) in the CAgrp. Conclusion: It is suggested that the proliferativeappearance of CA could be due to the imbalance betweencell growth and cell death which is caused by moreproliferation and less apoptosis in keratinocytes.展开更多
Epidemic dynamics in networks have attracted a great deal of attention from researchers of many fields. In this paper, we mainly study the global behaviors of discrete-time epidemic model in heterogenous networks. By ...Epidemic dynamics in networks have attracted a great deal of attention from researchers of many fields. In this paper, we mainly study the global behaviors of discrete-time epidemic model in heterogenous networks. By theoretical analysis, we show that the model can be characterized by the basic reproduction number R0. When R0 is smaller than unit, the disease-free equilibrium is globally stable, while R0 is larger than unit, the unique positive equilibrium is globally attractive.展开更多
基金Supported by Natural Science Foundation of Hebei Province(C2014407043)Educational Commission of Hebei Province(ZD2014071)+1 种基金Modern Agricultural IndustrialTechnology System of Hebei Province(HBCT2013090203)~~
文摘Coccidiosis is a protozoan disease that seriously threatens the poultry in-dustry. At present, the prevention and treatment of chicken coccidiosis mainly rely on chemical drugs and coccidia live vaccine. However, drug control has problems of drug resistance and drug residue, and the coccidia live vaccine has drawbacks of pathogenicity, high production costs and virulence enhancement. Instead, genetic en-gineering vaccine is easy to operate, stable, safe and efficient, so it has become a hot spot in the prevention of chicken coccidiosis. In this paper, the research status, immune mechanism, immune effect＇s influencing factors and cytokine adjuvant appli-cation of genetic engineering vaccine against chicken coccidiosis were reviewed to provide some reference for the research and application of chicken coccidiosis gene vaccine.
基金Basic science research program through the national research foundation of Korea(NRF)funded by the ministry of education(2013R1A1A2011947)
文摘Network epidemiology has become a core framework for investigating the role of human contact patterns in the spreadingof infectious diseases.In network epidemiology,one represents the contact structure as a network of nodes(individuals)connected bylinks(sometimes as a temporal network where the links are not continuously active)and the disease as a compartmental model(whereindividuals are assigned states with respect to the disease and follow certain transition rules between the states).In this paper,we discussfast algorithms for such simulations and also compare two commonly used versions,one where there is a constant recovery rate(the numberof individuals that stop being infectious per time is proportional to the number of such people);the other where the duration of the diseaseis constant.The results show that,for most practical purposes,these versions are qualitatively the same.
文摘Objecrive: To investigate the relationship between apoptosis and proliferating cell nuclear antigcn (PCNA)expression of keratinocytes in Condylomata acuminata (CA). Methods: PCNA expression was observed byimmunohistochemistry technique (ABC method) in 51 CAspecimens and 1 normal specimens of foreskin or vaginalmucosae. 55 specimens (40 in the CA group and 15 in thecontrol group) were randomly sampled for in situ labelingof apoptotic cells using the TUNEL method. Results: Positive expression of PCNA in CA and controlgroups were 90.2% and 77.8%, respectively, and theproliferation index in CA group was significantly higherthan that in the control group (P<0.001). The positive rateof apoptosis was 42.5% in the LA group and 53.3% in thecontrol group, and there were no significant differences inthe apoptotic index and apoptosis-proliferation ratiobetween two groups (P>0.05). The proliferation indexshowed a significant negativc correlation with theapoptosis-proliferation ratio (r=-0.62, P=0.01) in the CAgrp. Conclusion: It is suggested that the proliferativeappearance of CA could be due to the imbalance betweencell growth and cell death which is caused by moreproliferation and less apoptosis in keratinocytes.
文摘Epidemic dynamics in networks have attracted a great deal of attention from researchers of many fields. In this paper, we mainly study the global behaviors of discrete-time epidemic model in heterogenous networks. By theoretical analysis, we show that the model can be characterized by the basic reproduction number R0. When R0 is smaller than unit, the disease-free equilibrium is globally stable, while R0 is larger than unit, the unique positive equilibrium is globally attractive.
