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文拉法辛与SSRIs治疗抑郁症伴疼痛疗效观察 被引量:3
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作者 冯俊慧 魏月玲 马霞 《济宁医学院学报》 2007年第3期204-205,共2页
目的比较文拉法辛与SSRIs治疗伴发疼痛抑郁症的临床疗效差异。方法将126例伴疼痛抑郁症患者随机分为文拉法辛治疗组63例(≥150mg/d)和SSRIs治疗组63例[其中氟西汀20例(≥20mg/d),帕罗西汀26例(≥20mg/d)、舍曲林17例(≥50mg/d)],治疗时... 目的比较文拉法辛与SSRIs治疗伴发疼痛抑郁症的临床疗效差异。方法将126例伴疼痛抑郁症患者随机分为文拉法辛治疗组63例(≥150mg/d)和SSRIs治疗组63例[其中氟西汀20例(≥20mg/d),帕罗西汀26例(≥20mg/d)、舍曲林17例(≥50mg/d)],治疗时间6周;应用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、视觉模拟量表(VAS)和副反应量表(TESS)评定疗效和不良反应。结果文拉法辛组有效率80%,SSRIs组为76%,差异无统计学意义(P>0.05)。文拉法辛组第6周末HAMD分数下降(15.2±6.1分),SSRIs组下降(14.4±6.2分),差异无统计学意义(P>0.05)。文拉法辛组治疗第2、4、6周末VAS、HAMA减分值均明显高于SSRIs组,差异有统计学意义(P<0.05)。文拉法辛组不良反应发生率43%,SSRIs组发生率45%,差异无显著性(P>0.05)。结论文拉法辛与SSRIs对患者抑郁症状的治疗效果近似,但对疼痛症状和焦虑症状的改善,文拉法辛优于SSRIs,副反应无差异。 展开更多
关键词 疼痛性抑郁症 文拉法辛 SSRIS
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RANDOMIZED CONTROL STUDY ON DEPRESSION INDUCED BY CHRONIC PAIN TREATED WITH ACUPUNCTURE 被引量:5
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作者 曹雪梅 杨卓欣 +3 位作者 谢红亮 张研 张竟超 饶晓丹 《World Journal of Acupuncture-Moxibustion》 2007年第3期1-8,共8页
Objective To study and verify the efficacy of acupuncture on depression caused by chronic pain and to further analyze the advantages of acupuncture. Methods According to random number table, the cases were randomized ... Objective To study and verify the efficacy of acupuncture on depression caused by chronic pain and to further analyze the advantages of acupuncture. Methods According to random number table, the cases were randomized into experimental group and western medicine group, treated with acupuncture and antidepression drug (deanxit) respectively. Hamilton Depressive Scale (HAMD) and Visual Analogue Scale (VAS) were adopted for the evaluation before treatment and in the 1, 2 and 4 weeks after treatment in two groups successively. Results ① Very significant differences had been achieved on the comparisons of HAMD, VAS and HAMD reducing rate before and after treatment in experimental group (P 〈 0.01). Very significant differences had been achieved in the comparisons of HAMD, VAS and HAMD reducing rate before and after treatment in western medicine group (P 〈 0.01 ). ③Significant differences in HAMD reducing rate^* and VAS score^* * had been achieved in the comparison between experiment group and western medicine group 1 week after treatment (^* P〈0.01, ^* * P〈0.05). ④ The significant differences had not been received in HAMD, VAS score and HAMD reducing rate in 2 and 4 weeks after treatment in the comparison between experimental group and western medicine group (P 〉0.05). ⑤ No any harmful effect happened in experimental group after treatment, but it happened in western medicine group. Conclusion Both acupuncture and deanxit have achieved the definite therapeutic effects on depression caused by chronic pain, with similar efficacy. But the effects of acupuncture are obtained more quickly. In comparison of western medicine, acupuncture has no side and harmful effect. Additionally, acupuncture applies the multi-targeting and holistic modulation to the whole body. 展开更多
关键词 Acupuncture Chronic pain Depression Randomized control
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