目的研究探讨尿蛋白检测在肾损害性疾病早期诊治中的意义。方法随机抽取我院2012年7月至2014年收治的肾损害性疾病患者60例(观察组)与同期健康人员60例为研究对象。对两组研究对象均实行检测尿m Al B、β2-M、24 h尿总蛋白与及时尿m Al...目的研究探讨尿蛋白检测在肾损害性疾病早期诊治中的意义。方法随机抽取我院2012年7月至2014年收治的肾损害性疾病患者60例(观察组)与同期健康人员60例为研究对象。对两组研究对象均实行检测尿m Al B、β2-M、24 h尿总蛋白与及时尿m Al B/尿Cr,采用化学方法检测两组研究对象尿蛋白定性。结果检查结果显示,观察组研究对象各项尿检测均高于对照组,数据符合统计学差异(P<0.05);在观察组患者中肾炎、肾病综合征在进入ESRD的时候尚未出现异常,而在还没有进入ESRD的时候,高血压、糖尿病患者就已经显示尿蛋白检查结果异常,数据符合统计学差异(P<0.05);与此同时在检查的过程中发现,观察组患者m Al B、β2-M、及时尿m Al B/尿Cr检测结果均高于对照组,数据符合统计学差异(P<0.05)。结论在对肾损害性疾病早期诊断的过程中m Al B、β2-M、及时尿m Al B/尿Cr相较于尿蛋白定性更具敏感性,在早期诊断肾脏损害性疾病监测的过程中,可以将这这几项指标作为患者治疗效果与治疗后恢复状况的比较指标,而针对有可能引起慢性肾脏疾病如高血压、糖尿病的应当注意严密监测,以免漏诊。展开更多
Deficiencies in vitamins or other factors(B6,B12,folic acid, betaine)and genetic disorders for the metabolism of the non-protein amino acid-homocysteine(Hcy)lead to hyperhomocysteinemia(HHcy).HHcy is an integral compo...Deficiencies in vitamins or other factors(B6,B12,folic acid, betaine)and genetic disorders for the metabolism of the non-protein amino acid-homocysteine(Hcy)lead to hyperhomocysteinemia(HHcy).HHcy is an integral component of several disorders including cardiovascular disease,neurodegeneration,diabetes and alcoholic liver disease.HHcy unleashes mediators of inflammation such as NFκB,IL-1β,IL-6,and IL-8,increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide(NO),and induces endoplasrnic reticulum(ER)stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation,and inflammation.Animal models have played an important role in determining the biological effects of HHcy.ER stress may also be involved in other liver diseases such as α_1-antitrypsin(α_1-AT)deficiency and hepatitis C and/or B virus infection.Future research should evaluate the possible potentiative effects of alcohol and hepatic virus infection on ER stress-induced liver injury,study potentially beneficial effects of lowering Hcy and preventing ER stress in alcoholic humans,and examine polymorphisrn of Hcy metabolizing enzymes as potential risk-factors for the development of HHcy and liver disease.展开更多
Background Development of arterial dissection is thought to be an important key factor for bailout stenting in femoropopliteal disease. We aimed to evaluate the difference in dissection rate and outcomes between the t...Background Development of arterial dissection is thought to be an important key factor for bailout stenting in femoropopliteal disease. We aimed to evaluate the difference in dissection rate and outcomes between the treatment group with rotational atherectomy and with？out it. Methods From January 2011 to October 2016, we compared the angiography after balloon angioplasty （BA） of de-novo, femoropop？liteal, steno-occlusive lesions whether they were treated by rotational atherectomy prior to the BA or not. Fifty-nine lesions （8 occlusions; 3 involving popliteal segment; lesion length： 86.3 ± 66.8 mm） in 44 patients （29 males; mean age 66.9 ± 9.7 years） were enrolled for this review. Results Forty-two lesions were treated using rotational atherectomy, prior to BA while 17 were recanalized firstly by BA. Clinical and lesion characteristics were not different between the groups. However, the rate of significant arterial dissection （type C to F） was lower in the atherectomy group （88.2% vs. 42.9%; P = 0.001）. In multivariate analysis, use of the atherectomy device was the only risk factor for prevention of development of significant dissection （P = 0.013; OR = 0.12; 95% CI： 0.025？0.642）. Patients were treated either by the angioplasty alone, drug coated balloon or stent insertion. There was lower trend in target vessel revascularization and primary patency toward the atherectomy group （low rank P = 0.108 and 0.166）, however secondary patency was significantly better （low rank P = 0.001）. Conclusions Rotational atherec？tomy before BA reduced the rate of significant dissection and therefore, might be a valuable option for minimizing need of bailout stenting.展开更多
Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western countries.Fatty liver i...Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western countries.Fatty liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin resistance.Hepatic steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of patients.Besides liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been established.Visceral obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver damage.Most of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver damage.Adiponectin is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or NASH.Adiponectin antagonizes excess lipid storage in the liver and protects from inflammation and fibrosis.This review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin.展开更多
文摘目的研究探讨尿蛋白检测在肾损害性疾病早期诊治中的意义。方法随机抽取我院2012年7月至2014年收治的肾损害性疾病患者60例(观察组)与同期健康人员60例为研究对象。对两组研究对象均实行检测尿m Al B、β2-M、24 h尿总蛋白与及时尿m Al B/尿Cr,采用化学方法检测两组研究对象尿蛋白定性。结果检查结果显示,观察组研究对象各项尿检测均高于对照组,数据符合统计学差异(P<0.05);在观察组患者中肾炎、肾病综合征在进入ESRD的时候尚未出现异常,而在还没有进入ESRD的时候,高血压、糖尿病患者就已经显示尿蛋白检查结果异常,数据符合统计学差异(P<0.05);与此同时在检查的过程中发现,观察组患者m Al B、β2-M、及时尿m Al B/尿Cr检测结果均高于对照组,数据符合统计学差异(P<0.05)。结论在对肾损害性疾病早期诊断的过程中m Al B、β2-M、及时尿m Al B/尿Cr相较于尿蛋白定性更具敏感性,在早期诊断肾脏损害性疾病监测的过程中,可以将这这几项指标作为患者治疗效果与治疗后恢复状况的比较指标,而针对有可能引起慢性肾脏疾病如高血压、糖尿病的应当注意严密监测,以免漏诊。
基金Supported by the U.S.National Institute of Alcohol Abuse and Alcoholism,R01 AA014428 and by the Robert E.and May R.Wright Foundation,No.263
文摘Deficiencies in vitamins or other factors(B6,B12,folic acid, betaine)and genetic disorders for the metabolism of the non-protein amino acid-homocysteine(Hcy)lead to hyperhomocysteinemia(HHcy).HHcy is an integral component of several disorders including cardiovascular disease,neurodegeneration,diabetes and alcoholic liver disease.HHcy unleashes mediators of inflammation such as NFκB,IL-1β,IL-6,and IL-8,increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide(NO),and induces endoplasrnic reticulum(ER)stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation,and inflammation.Animal models have played an important role in determining the biological effects of HHcy.ER stress may also be involved in other liver diseases such as α_1-antitrypsin(α_1-AT)deficiency and hepatitis C and/or B virus infection.Future research should evaluate the possible potentiative effects of alcohol and hepatic virus infection on ER stress-induced liver injury,study potentially beneficial effects of lowering Hcy and preventing ER stress in alcoholic humans,and examine polymorphisrn of Hcy metabolizing enzymes as potential risk-factors for the development of HHcy and liver disease.
文摘Background Development of arterial dissection is thought to be an important key factor for bailout stenting in femoropopliteal disease. We aimed to evaluate the difference in dissection rate and outcomes between the treatment group with rotational atherectomy and with？out it. Methods From January 2011 to October 2016, we compared the angiography after balloon angioplasty （BA） of de-novo, femoropop？liteal, steno-occlusive lesions whether they were treated by rotational atherectomy prior to the BA or not. Fifty-nine lesions （8 occlusions; 3 involving popliteal segment; lesion length： 86.3 ± 66.8 mm） in 44 patients （29 males; mean age 66.9 ± 9.7 years） were enrolled for this review. Results Forty-two lesions were treated using rotational atherectomy, prior to BA while 17 were recanalized firstly by BA. Clinical and lesion characteristics were not different between the groups. However, the rate of significant arterial dissection （type C to F） was lower in the atherectomy group （88.2% vs. 42.9%; P = 0.001）. In multivariate analysis, use of the atherectomy device was the only risk factor for prevention of development of significant dissection （P = 0.013; OR = 0.12; 95% CI： 0.025？0.642）. Patients were treated either by the angioplasty alone, drug coated balloon or stent insertion. There was lower trend in target vessel revascularization and primary patency toward the atherectomy group （low rank P = 0.108 and 0.166）, however secondary patency was significantly better （low rank P = 0.001）. Conclusions Rotational atherec？tomy before BA reduced the rate of significant dissection and therefore, might be a valuable option for minimizing need of bailout stenting.
基金Supported by The Faculty of Medicine of the University of Regensburg (ReForM C)The Deutsche Forschungsgemein-schaft
文摘Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western countries.Fatty liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin resistance.Hepatic steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of patients.Besides liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been established.Visceral obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver damage.Most of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver damage.Adiponectin is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or NASH.Adiponectin antagonizes excess lipid storage in the liver and protects from inflammation and fibrosis.This review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin.
