目的了解我院中药处方中妊娠患者的疾病种类及用药合理情况。方法抽取2017年10月~2019年10月期间我院医师为妊娠患者开具的中药处方300张,利用Microsoft Offic e Excel 2016统计软件比较不同孕期阶段发生疾病的种类、频率及使用的中药处...目的了解我院中药处方中妊娠患者的疾病种类及用药合理情况。方法抽取2017年10月~2019年10月期间我院医师为妊娠患者开具的中药处方300张,利用Microsoft Offic e Excel 2016统计软件比较不同孕期阶段发生疾病的种类、频率及使用的中药处方,分析我院医师为妊娠患者开具的中药处方是否合理。结果孕早、中、晚时期各种疾病均可能发生,孕妇外感、先兆流产、阴道炎和妊娠恶阻的人数较多,腹泻和皮肤瘙痒发生频率分别为0.33%、1.67%、1.00%和0.00%、0.67%和1.67%。针对上述疾病,医生为妊娠患者开具的中药处方基本合理,存在少数使用妊娠禁忌药情况。结论在妊娠各阶段疾病的治疗中,我院医师开具的中药处方相对安全,为妊娠患者疾病的治疗和胎儿的安全提供了保障。展开更多
CD4^＋CD25^＋ Regulatory T cells （Treg） have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion of Treg benefits to the disease status of HIV infection remains undefined...CD4^＋CD25^＋ Regulatory T cells （Treg） have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion of Treg benefits to the disease status of HIV infection remains undefined. To address this issue, we enumerated the Treg absolute counts and frequency in 75 antiviral-naive HIV-1-infected individuals in this study. It was found that HIV-infected patients displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition, with disease progression indicated by CD4 T-cell absolute counts, circulating Treg frequency gradually increased; while Treg absolute counts were gradually decreased, suggesting that the alteration of Treg number closely correlated with disease progression in HIV infection Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro. Thus, our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection, influencing the disease progression.展开更多
Retinal dystrophies are genetically determined diseases, implying the loss of function of the retina with a wide phenotypic and genotypic variability. There are very few phenotypic, genotypic and epidemiological data ...Retinal dystrophies are genetically determined diseases, implying the loss of function of the retina with a wide phenotypic and genotypic variability. There are very few phenotypic, genotypic and epidemiological data on retinal dystrophies in Latin America. The Objective of this study is to describe the epidemioiogical and clinical characteristics of hereditary retinal and choroidal diseases, in retina practices in Panama. A descriptive study, from 2012 to 2013, was performed in the main retina practices in Panama. All detected patients were given a free appointment to gather their phenotypic characteristics and pedigrees. An incidence of five new cases per year, and an accumulated incidence of 5.35 patients per I0,000 was calculated for the public hospitals. A frequency of 2.7 cases per 1,000 patients was observed in the main retina practices, where 69% had rod-cone dystrophies, 14.3% cone-rod dystrophies, 7.1% Stargardt disease, 4.8% Stargardt-like macular dystrophy and two patients presented other dystrophies. Blindness was the main family antecedent （45.2%）. Retinal pigment was present in 59% and strabismus in 21.4% of the patients. Rod-cone and cone-rod dystrophies had similar geographic distribution and the autosomal recessive inheritance pattern was the most frequently observed. This study gives the first phenotypic data of retinal dystrophies in Panama to orient clinicians for a better diagnosis and phenotyping-genotyping correlation for retinal dystrophies in Central America.展开更多
文摘目的了解我院中药处方中妊娠患者的疾病种类及用药合理情况。方法抽取2017年10月~2019年10月期间我院医师为妊娠患者开具的中药处方300张,利用Microsoft Offic e Excel 2016统计软件比较不同孕期阶段发生疾病的种类、频率及使用的中药处方,分析我院医师为妊娠患者开具的中药处方是否合理。结果孕早、中、晚时期各种疾病均可能发生,孕妇外感、先兆流产、阴道炎和妊娠恶阻的人数较多,腹泻和皮肤瘙痒发生频率分别为0.33%、1.67%、1.00%和0.00%、0.67%和1.67%。针对上述疾病,医生为妊娠患者开具的中药处方基本合理,存在少数使用妊娠禁忌药情况。结论在妊娠各阶段疾病的治疗中,我院医师开具的中药处方相对安全,为妊娠患者疾病的治疗和胎儿的安全提供了保障。
基金The National Outstanding Youth Foundation of China (30525042)National 973 project of China (2006CB504201,2006CB504205)
文摘CD4^＋CD25^＋ Regulatory T cells （Treg） have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion of Treg benefits to the disease status of HIV infection remains undefined. To address this issue, we enumerated the Treg absolute counts and frequency in 75 antiviral-naive HIV-1-infected individuals in this study. It was found that HIV-infected patients displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition, with disease progression indicated by CD4 T-cell absolute counts, circulating Treg frequency gradually increased; while Treg absolute counts were gradually decreased, suggesting that the alteration of Treg number closely correlated with disease progression in HIV infection Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro. Thus, our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection, influencing the disease progression.
文摘Retinal dystrophies are genetically determined diseases, implying the loss of function of the retina with a wide phenotypic and genotypic variability. There are very few phenotypic, genotypic and epidemiological data on retinal dystrophies in Latin America. The Objective of this study is to describe the epidemioiogical and clinical characteristics of hereditary retinal and choroidal diseases, in retina practices in Panama. A descriptive study, from 2012 to 2013, was performed in the main retina practices in Panama. All detected patients were given a free appointment to gather their phenotypic characteristics and pedigrees. An incidence of five new cases per year, and an accumulated incidence of 5.35 patients per I0,000 was calculated for the public hospitals. A frequency of 2.7 cases per 1,000 patients was observed in the main retina practices, where 69% had rod-cone dystrophies, 14.3% cone-rod dystrophies, 7.1% Stargardt disease, 4.8% Stargardt-like macular dystrophy and two patients presented other dystrophies. Blindness was the main family antecedent （45.2%）. Retinal pigment was present in 59% and strabismus in 21.4% of the patients. Rod-cone and cone-rod dystrophies had similar geographic distribution and the autosomal recessive inheritance pattern was the most frequently observed. This study gives the first phenotypic data of retinal dystrophies in Panama to orient clinicians for a better diagnosis and phenotyping-genotyping correlation for retinal dystrophies in Central America.
