Diabetic nephropathy(DN)is currently the most common complication of diabetes.It is considered to be one of the leading causes of end-stage renal disease(ESRD)and affects many diabetic patients.The pathogenesis of DN ...Diabetic nephropathy(DN)is currently the most common complication of diabetes.It is considered to be one of the leading causes of end-stage renal disease(ESRD)and affects many diabetic patients.The pathogenesis of DN is extremely complex and has not yet been clarified;however,in recent years,increasing evidence has shown the important role of innate immunity in DN pathogenesis.Pattern recognition receptors(PRRs)are important components of the innate immune system and have a significant impact on the occurrence and development of DN.In this review,we classify PRRs into secretory,endocytic,and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments.PRRs can recognize related pathogen-associated molecular patterns(PAMPs)and danger-associated molecular patterns(DAMPs),thus triggering a series of inflammatory responses,promoting renal fibrosis,and finally causing renal impairment.In this review,we describe the proposed role of each type of PRRs in the development and progression of DN.展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.81060063 and 81660129).
文摘Diabetic nephropathy(DN)is currently the most common complication of diabetes.It is considered to be one of the leading causes of end-stage renal disease(ESRD)and affects many diabetic patients.The pathogenesis of DN is extremely complex and has not yet been clarified;however,in recent years,increasing evidence has shown the important role of innate immunity in DN pathogenesis.Pattern recognition receptors(PRRs)are important components of the innate immune system and have a significant impact on the occurrence and development of DN.In this review,we classify PRRs into secretory,endocytic,and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments.PRRs can recognize related pathogen-associated molecular patterns(PAMPs)and danger-associated molecular patterns(DAMPs),thus triggering a series of inflammatory responses,promoting renal fibrosis,and finally causing renal impairment.In this review,we describe the proposed role of each type of PRRs in the development and progression of DN.
