茶尺蠖感染核型多角体病毒后病死时间分布的数学模拟

本文观察了１４℃、１８℃、２２℃、２６℃４种恒温和杭州５一６月自然变温下，茶尺蠖各龄初幼虫感染核型多角体病毒后的病死时间分布。结果表明，各恒温下幼虫累计相对病死频率的时间分布（Ｔ－分布）趋于一致。病死时间正规化后；同龄幼虫在各恒温下的病死时间分布可用公共Ｔ－分布代表，并可用Ｗｅｉｂｕｌｌ函数很好地加以拟合。采用此法，也可较好地模拟自然变温下幼虫的病死时间分布。

子午流注与病死时间规律初探

子午流注学说 ,其理论源于《内经》中的经脉流注、脏气法时、五脏传移、五脏逆传及阴阳应象规律。若违背这些规律 ,就会出现病理现象 ,以至死亡。以 6 45例住院患者的死亡时间为基点 ,对子午流注及病死规律作一探讨。

温度对甜菜夜蛾核型多角体病毒流行的影响

在恒温条件下 ,研究了甜菜夜蛾 3龄初幼虫感染核型多角体病毒后的病死速率、病死时间分布与温度关系。结果表明 ,在2 9℃以下 ,随温度的升高 ,病死率增加 ,幼虫病死速率加快 ,病死持续时间缩短 ;该病毒的热抑制温度在 2 7℃左右。改进的Schoolfield模型、Stinner模型可很好地描述幼虫病死速率与温度关系。甜菜夜蛾种群饲毒后的每日病死率可用时间 -剂量 -死亡率模型较好地拟合 ,模型模拟值与实测值有较好的吻合 (Hosmer- L em oshow统计量检验不显著 ) ,方程中各项系数经 t检验达极显著水平 ;不同温度下的幼虫累计病死时间分布可用 Weibull模型、Gompertz模型及 L ogistic模型拟合 ,模型经 F检验显著 ,模型中各系数经 t检验均达到或接近显著水平。用剩余平方和 Q比较各模型的拟合程度 ,以 L ogistic模型拟合最好 ,Gompertz模型次之 ,Weibull模型拟合效果稍差。

宿主虫龄对斜纹夜蛾核型多角体病毒病流行的影响

通过对田间感病幼虫跟踪观察 ,研究了对斜纹夜蛾不同龄期幼虫喷施斜纹夜蛾核型多角体病毒后 ,病毒病在当代种群中的田间流行动态 .结果表明 ,随虫龄的增大 ,幼虫对病毒的敏感性下降 ,宿主幼虫病死率降低 ,病死速率减慢 ,病死持续时间延长 ,幼虫病亡和疾病现患始期、高峰期推迟 .对不同龄期幼虫喷施病毒后 ,幼虫每日病死时间分布可用互补重对数模型较好地拟合 (Hosmer Lemoshow统计量检验不显著 ) ,模型中各项系数经t检验达极显著水平 ;疾病现患时间分布可用Holliday模型拟合 ,模型经F检验显著 ,方程中各项系数达到或接近显著水平 ;幼虫逐日病死时间分布可用Weibull模型、Gompertz模型及Lo gistic模型较好地拟合 ,通过用剩余平方和Q比较各模型的拟合程度 。

活血化瘀方药对脑出血作用及脑出血发病节律的研究进展

近年的实验研究表明 :活血化瘀方药对脑出血的作用包括促进血肿吸收、减轻周围脑组织炎症及水肿、减缓颅内压增高、改善局部血液循环、保护脑组织免受坏死以及有利于神经功能恢复等作用 ;脑出血的发病与死亡存在一定的年、月、季节及昼夜节律性 。

characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases

AIM: To reveal the frequency, characteristics and prognosis of chronic intestinal pseudo-obstruction (CIP) in mitochondrial disease patients. METHODS: Between January 2000 and December 2010, 31 patients (13 males and 18 females) were di-agnosed with mitochondrial diseases at our hospital. We conducted a retrospective review of the patients' sex, subclass of mitochondrial disease, age at onset of mitochondrial disease, frequency of CIP and the age at its onset, and the duration of survival. The age at onset or at the first diagnosis of the disorder that led to the clinical suspicion of mitochondrial disease was also examined. RESULTS: Twenty patients were sub-classified with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), 8 with chronic progressive external ophthalmoplegia (CPEO), and 3 with myoclonus epilepsy associated with ragged-red fibers (MERRF). Nine patients were diagnosed with CIP, 8 of the 20 (40.0%) patients with MELAS, 0 of the 8 (0.0%) patients with CPEO, and 1 of the 3 (33.3%) patients with MERRF. The median age (range) at the diagnosis and the median age at onset of mitochondrial disease were 40 (17-69) and 25 (12-63) years in patients with CIP, and 49 (17-81) and 40 (11-71) years in patients without CIP. During the survey period, 5 patients (4 patients with MELAS and 1 with CPEO) died. The cause of death was cardiomyopathy in 2 patients with MELAS, cerebral infarction in 1 patient with MELAS, epilepsy and aspiration pneumonia in 1 patient with MELAS, and multiple metastases from gastric cancer and aspiration pneumonia in 1 patient with CPEO. CONCLUSION: Patients with CIP tend to have disorders that are suspected to be related to mitochondrial diseases at younger ages than are patients without CIP.

Extra-pancreatic complications,especially hemodialysis predict mortality and length of stay,in ICU patients admitted with acute pancreatitis

Background and aims:Patients in the intensive care unit(ICU)with acute pancreatitis(AP)are at risk for extra-pancreatic complications given their severe illness and prolonged length of stay.We sought to determine the rate of extra-pancreatic complications and its effect on length of stay(LOS)and mortality in ICU patients with AP.Methods:We performed a retrospective cohort study of ICU patients admitted to a tertiary-care center with a diagnosis of AP.A total of 287 ICU patients had a discharge diagnosis of AP,of which 163 met inclusion criteria.We calculated incidence rates of extra-pancreatic complications and performed a univariate and multi-variable analysis to determine predictors of LOS and mortality.Results:There were a total of 158 extra-pancreatic complications(0.97 extra-pancreatic complications per patient).Ninetyfive patients had at least one extra-pancreatic complication,whereas 68 patients had no extra-pancreatic complications.Patients with extra-pancreatic complications had a significantly longer LOS(14.7 vs 8.8 days,p<0.01)when controlling for local pancreatic complications.Patients with non-infectious extra-pancreatic complications had a higher rate of mortality(24.0%vs 16.2%,p=0.04).Patients requiring dialysis was an independent predictor for LOS and mortality(incidence risk ratio[IRR]1.73,95%confidence interval[CI]:1.263–2.378 and IRR 1.50,95%CI 1.623–6.843,p<0.01)on multi-variable analysis.Coronary events were also a predictor for mortality(p=0.05).Other extra-pancreatic complications were not significant.Conclusions:Extra-pancreatic complications occur frequently in ICU patients with AP and impact LOS.Patients with noninfectious extra-pancreatic complications have a higher mortality rate.After controlling for local pancreatic complications,patients requiring dialysis remained an independent predictor for LOS and mortality.