Steatosis in patients with chronic hepatitis C (CHC) may be the result of both viral and host factors. To evaluate: (1) the relationship between steatosis and either host or viral factors; (2) the correlation between ...Steatosis in patients with chronic hepatitis C (CHC) may be the result of both viral and host factors. To evaluate: (1) the relationship between steatosis and either host or viral factors; (2) the correlation between steatosis and fibrosi s in patientswith CHC. A consecutive series of 349 patients were evaluated for s teatosis. At liver biopsy, patients were tested for virological, and laboratory analysis and questioned for alcohol consumption. Logistic regression analysis de monstrated that steatosis was independently associated with genotype 3a (odds ra tio, OR 3.5), alcohol intake at the time of biopsy (OR 2.6) and age >35 years (O R 2.7). In multivariate analysis the presence of fibrosis was associated with pa st alcohol abuse (OR 3.7), and age older than 44 years (OR 2.2). Overall, a weak correlation was found between grade of steatosis and fibrosis score (r=0.861, P =0.05), which disappeared excluding patients without past or current alcohol int ake. A direct correlation emerged between grade of steatosis and both ‘grading ’and ‘staging’only in patients with genotypes other than 3a. Genotype 3a is t hemain risk factor for steatosis in patientswith CHC. The grade of steatosis cor related with both grading and staging only in patients with genotypes other than 3a and this relationship is strictly linked to alcohol consumption.展开更多
文摘患者,女,54岁,入院时间为2010年10月11日,主诉体检时超声发现膀胱肿瘤10余天。现病史：体检超声发现膀胱肿物,无痛性血尿及发热,无尿频、尿急、尿痛,无腹痛及腹泻。既往史：否认高血压、心脏病、头痛头晕病史。入院后血常规、肝功能、肾功能、凝血、病毒学检查无明显异常。泌尿系CTU（平扫＋增强＋重建）：膀胱顶部偏右侧见一类圆形结节状影,突入膀胱腔内,大小约9 mm,
文摘Steatosis in patients with chronic hepatitis C (CHC) may be the result of both viral and host factors. To evaluate: (1) the relationship between steatosis and either host or viral factors; (2) the correlation between steatosis and fibrosi s in patientswith CHC. A consecutive series of 349 patients were evaluated for s teatosis. At liver biopsy, patients were tested for virological, and laboratory analysis and questioned for alcohol consumption. Logistic regression analysis de monstrated that steatosis was independently associated with genotype 3a (odds ra tio, OR 3.5), alcohol intake at the time of biopsy (OR 2.6) and age >35 years (O R 2.7). In multivariate analysis the presence of fibrosis was associated with pa st alcohol abuse (OR 3.7), and age older than 44 years (OR 2.2). Overall, a weak correlation was found between grade of steatosis and fibrosis score (r=0.861, P =0.05), which disappeared excluding patients without past or current alcohol int ake. A direct correlation emerged between grade of steatosis and both ‘grading ’and ‘staging’only in patients with genotypes other than 3a. Genotype 3a is t hemain risk factor for steatosis in patientswith CHC. The grade of steatosis cor related with both grading and staging only in patients with genotypes other than 3a and this relationship is strictly linked to alcohol consumption.
