Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and nece...Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and economic way. The influenza subunit and VLP vaccines, taking the advantage of recombinant DNA technologies and expression system platforms, can be produced in such an ideal way. This review summarized the recent advancements in the research and development of influenza subunit and VLP vaccines based on the recombinant expression of hemagglutinin antigen (HA), neuraminidase antigen (NA), Matrix 2 protein (M2) and nucleocapsid protein (NP). It would help to get insight into the current stage of influenza vaccines, and suggest the future design and development of novel influenza vaccines.展开更多
This is a conceptual paper which was motivated by the fact that Swaziland does not have a Social Accounting Matrix （SAM） in place and as such there are many shocks that affect that country＇s economy but which canno...This is a conceptual paper which was motivated by the fact that Swaziland does not have a Social Accounting Matrix （SAM） in place and as such there are many shocks that affect that country＇s economy but which cannot be analyzed effectively. Most notable of this is the economic effects of the HIV/AIDS scourge that is affecting that country of which it has been difficult to determine the effects it has had on the economy in an objective manner. This paper will highlight the usefulness of the SAM and Computable General Equilibrium （CGE） models in analyzing the possible economic effects of HIV/AIDS in Swaziland. The absence of a SAM for Swaziland means that empirical analysis of the effect of the disease on the economy could not be undertaken, but it is hoped that the arguments presented here will contribute to the use of these methods as tools for analyzing various shocks in an economy. The paper is divided into 4 parts. Part 1 is a brief introduction into the Swaziland economy, part 2 is a brief description of the SAM, description of CGE Modeling and a detailed application of the SAM data into the CGE modeling framework, part 3 introduces the HIV/AIDS situation in Swaziland and models its possible effects using a macroeconomic SAM and part 4 is the discussion and conclusion. The main aim of the paper then is to lay the basic framework to help small developing countries develop practical SAMs that will become an important tool in analyzing the performances of their economies.展开更多
There has been a global attack of A/H1N1 virus in 2009, which widely affected the world＇s normal stability and economic development. Since the emergence of the first diagnosed A/H1N1 influenza infected person in 11 M...There has been a global attack of A/H1N1 virus in 2009, which widely affected the world＇s normal stability and economic development. Since the emergence of the first diagnosed A/H1N1 influenza infected person in 11 May 2009 in China, very strict policy including quarantine and isolation measures were widely implemented to control the spread of this disease before the vaccine appeared. We propose a compartmental model that mimics the infection process of A/H1N1 under control strategies taken in China's Mainland. Apart from theoretical analysis, using the statistic data of Shaanxi Province, we estimated the unknown epidemiological parameters of this disease in Shaanxi via least-squares fitting method. The estimated control reproductive number of H1N1 for its first peak was Rc1 = 2.555 （95% CI： 2.362 2.748） and that for the second peak was Rc2 = 1.886 （95% CI： 1.765-2.001）. Our findings in this paper suggest that neither quarantine nor isolation measures could be relaxed, and the implementation of these interventions can reduce the pandemic outbreak of A/H1N1 pandemic significantly.展开更多
基金The Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KSCX2-EW-G-8)
文摘Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and economic way. The influenza subunit and VLP vaccines, taking the advantage of recombinant DNA technologies and expression system platforms, can be produced in such an ideal way. This review summarized the recent advancements in the research and development of influenza subunit and VLP vaccines based on the recombinant expression of hemagglutinin antigen (HA), neuraminidase antigen (NA), Matrix 2 protein (M2) and nucleocapsid protein (NP). It would help to get insight into the current stage of influenza vaccines, and suggest the future design and development of novel influenza vaccines.
文摘This is a conceptual paper which was motivated by the fact that Swaziland does not have a Social Accounting Matrix （SAM） in place and as such there are many shocks that affect that country＇s economy but which cannot be analyzed effectively. Most notable of this is the economic effects of the HIV/AIDS scourge that is affecting that country of which it has been difficult to determine the effects it has had on the economy in an objective manner. This paper will highlight the usefulness of the SAM and Computable General Equilibrium （CGE） models in analyzing the possible economic effects of HIV/AIDS in Swaziland. The absence of a SAM for Swaziland means that empirical analysis of the effect of the disease on the economy could not be undertaken, but it is hoped that the arguments presented here will contribute to the use of these methods as tools for analyzing various shocks in an economy. The paper is divided into 4 parts. Part 1 is a brief introduction into the Swaziland economy, part 2 is a brief description of the SAM, description of CGE Modeling and a detailed application of the SAM data into the CGE modeling framework, part 3 introduces the HIV/AIDS situation in Swaziland and models its possible effects using a macroeconomic SAM and part 4 is the discussion and conclusion. The main aim of the paper then is to lay the basic framework to help small developing countries develop practical SAMs that will become an important tool in analyzing the performances of their economies.
文摘There has been a global attack of A/H1N1 virus in 2009, which widely affected the world＇s normal stability and economic development. Since the emergence of the first diagnosed A/H1N1 influenza infected person in 11 May 2009 in China, very strict policy including quarantine and isolation measures were widely implemented to control the spread of this disease before the vaccine appeared. We propose a compartmental model that mimics the infection process of A/H1N1 under control strategies taken in China's Mainland. Apart from theoretical analysis, using the statistic data of Shaanxi Province, we estimated the unknown epidemiological parameters of this disease in Shaanxi via least-squares fitting method. The estimated control reproductive number of H1N1 for its first peak was Rc1 = 2.555 （95% CI： 2.362 2.748） and that for the second peak was Rc2 = 1.886 （95% CI： 1.765-2.001）. Our findings in this paper suggest that neither quarantine nor isolation measures could be relaxed, and the implementation of these interventions can reduce the pandemic outbreak of A/H1N1 pandemic significantly.
