临床研究证实,抗-遗传型Mab能有效治疗致命性肿瘤黑素瘤。在第Ⅱ阶段的临床试验中,研究者发现Mab MK2-23诱导免疫性并使第Ⅳ期黑素瘤患者中60％延长存活期。除ImClone Systems Inc.发展的抗-idMab外,其它Mab模拟抗原不是特别致免疫的。...临床研究证实,抗-遗传型Mab能有效治疗致命性肿瘤黑素瘤。在第Ⅱ阶段的临床试验中,研究者发现Mab MK2-23诱导免疫性并使第Ⅳ期黑素瘤患者中60％延长存活期。除ImClone Systems Inc.发展的抗-idMab外,其它Mab模拟抗原不是特别致免疫的。而MKα-23模拟存在于80～85％黑素瘤细胞上的膜蛋白的高分子量黑素瘤抗体。给予的抗体尚不能消除肿瘤。展开更多
Optic neuritis presentations are thought to have a better prognosis. The aim of our study was to compare conversion to multiple sclerosis on the different topographies of CISs. We prospectively evaluated 320 patients ...Optic neuritis presentations are thought to have a better prognosis. The aim of our study was to compare conversion to multiple sclerosis on the different topographies of CISs. We prospectively evaluated 320 patients with CISs (123 with optic neuritis, 78 with brainstem syndromes, 89 with spinal cord syndromes, and 30 with other topographies) who were observed for a median of 39 months. Patients underwent brain MRI within 3 months of their first attack and again 12 months later. Conversion to multiple sclerosis determined either clinically or by MRI was evaluated according to topography. Baseline MRI was normal in 49.2% of patients with optic neuritis compared with 24% in brainstem syndromes, 24% in spinal cord syndromes, and 18.5% in other syndromes. Optic neuritis behaved differently from the other CISs for lower conversion to clinically definite multiple sclerosis and smaller proportion of patients fulfilling MRI dissemination in space, time, or both. Nevertheless, when only patients with abnormal cranial MRI results at baseline were selected, no differences for clinical or MRI conversion were found. Optic neuritis has a smaller risk for conversion to multiple sclerosis. Nevertheless, MRI at baseline, not CIS topography, appears to be the crucial issue at multiple sclerosis presentation.展开更多
Cervical cord magnetization transfer ratio (MTR) histograms were obtained from 45 patients at presentation with clinically isolated syndromes (CIS) suggestive ofmultiple sclerosis (MS). The mean values of MTR histogra...Cervical cord magnetization transfer ratio (MTR) histograms were obtained from 45 patients at presentation with clinically isolated syndromes (CIS) suggestive ofmultiple sclerosis (MS). The mean values of MTR histogram derived metrics were not different between CIS patients and healthy control subjects or between patients with and without evidence of disease dissemination in time. Only three patients showed significantly lower cord MTR values than control subjects. These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS.展开更多
文摘临床研究证实,抗-遗传型Mab能有效治疗致命性肿瘤黑素瘤。在第Ⅱ阶段的临床试验中,研究者发现Mab MK2-23诱导免疫性并使第Ⅳ期黑素瘤患者中60％延长存活期。除ImClone Systems Inc.发展的抗-idMab外,其它Mab模拟抗原不是特别致免疫的。而MKα-23模拟存在于80～85％黑素瘤细胞上的膜蛋白的高分子量黑素瘤抗体。给予的抗体尚不能消除肿瘤。
文摘Optic neuritis presentations are thought to have a better prognosis. The aim of our study was to compare conversion to multiple sclerosis on the different topographies of CISs. We prospectively evaluated 320 patients with CISs (123 with optic neuritis, 78 with brainstem syndromes, 89 with spinal cord syndromes, and 30 with other topographies) who were observed for a median of 39 months. Patients underwent brain MRI within 3 months of their first attack and again 12 months later. Conversion to multiple sclerosis determined either clinically or by MRI was evaluated according to topography. Baseline MRI was normal in 49.2% of patients with optic neuritis compared with 24% in brainstem syndromes, 24% in spinal cord syndromes, and 18.5% in other syndromes. Optic neuritis behaved differently from the other CISs for lower conversion to clinically definite multiple sclerosis and smaller proportion of patients fulfilling MRI dissemination in space, time, or both. Nevertheless, when only patients with abnormal cranial MRI results at baseline were selected, no differences for clinical or MRI conversion were found. Optic neuritis has a smaller risk for conversion to multiple sclerosis. Nevertheless, MRI at baseline, not CIS topography, appears to be the crucial issue at multiple sclerosis presentation.
文摘Cervical cord magnetization transfer ratio (MTR) histograms were obtained from 45 patients at presentation with clinically isolated syndromes (CIS) suggestive ofmultiple sclerosis (MS). The mean values of MTR histogram derived metrics were not different between CIS patients and healthy control subjects or between patients with and without evidence of disease dissemination in time. Only three patients showed significantly lower cord MTR values than control subjects. These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS.
