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利培酮口服液治疗老年期痴呆患者病理性行为对照研究 被引量:5
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作者 白丽莉 陈铁光 周宝林 《临床精神医学杂志》 2010年第3期192-193,共2页
目的:对具有病理性行为的老年期痴呆患者分别给予利培酮和氟哌啶醇治疗的疗效进行比较。方法:65例伴有病理性行为的老年期痴呆患者随机分为研究组33例和对照组32例,分别给予利培酮口服液和氟哌啶醇针剂治疗。疗程2周。于治疗前及治疗2h... 目的:对具有病理性行为的老年期痴呆患者分别给予利培酮和氟哌啶醇治疗的疗效进行比较。方法:65例伴有病理性行为的老年期痴呆患者随机分为研究组33例和对照组32例,分别给予利培酮口服液和氟哌啶醇针剂治疗。疗程2周。于治疗前及治疗2h、24h、72h、1周和2周采用痴呆病理行为评定量表(BEHAVE-AD)和治疗中出现的症状量表(TESS)评定疗效及不良反应,并观察服药依从性。结果:利培酮口服液与氟哌啶醇针剂疗效相仿(P>0.05),但利培酮不良反应更小,依从性更好(P<0.05或P<0.01)。结论:利培酮口服液更适用于老年期痴呆患者的病理性行为的治疗。 展开更多
关键词 老年期痴呆 病理性行为 利培酮 氟哌啶醇
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利培酮口服液与片剂在治疗痴呆患者病理性行为中的临床差异性研究 被引量:2
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作者 孙秀琪 《中华灾害救援医学》 2020年第12期709-711,共3页
目的分析比较利培酮口服液与片剂治疗痴呆患者病理性行为的临床效果。方法选取北京市大兴区心康医院2019-01至2019-10的住院痴呆患者55例,按照随机分组法,分为对照组(n=27)和观察组(n=28),对照组患者给予利培酮片剂治疗,观察组患者给予... 目的分析比较利培酮口服液与片剂治疗痴呆患者病理性行为的临床效果。方法选取北京市大兴区心康医院2019-01至2019-10的住院痴呆患者55例,按照随机分组法,分为对照组(n=27)和观察组(n=28),对照组患者给予利培酮片剂治疗,观察组患者给予利培酮口服液治疗。比较两组患者的治疗依从性、治疗前后患者病理行为地阿尔茨海默病病理行为评分表(behavioral pathology in Alzheimer's disease rating scale,BEHAVE-AD)评分及总有效率。结果观察组治疗依从性高于对照组,差异具有统计学意义(P<0.05);两组治疗前后病理行为BEHAVE-AD量表评分比较,两组治疗后的第4、8周末两组BEHAVEAD评分和治疗前比较有显著差异,差异具有统计学意义(P<0.05)。两组副反应量表(Treatment Emergent Symptom Scale,TESS)评定比较显示,组间差异具有统计学意义(P<0.05)。结论利培酮口服液与片剂治疗痴呆患者病理性行为的临床效果均比较好,且疗效相似,均可改善患者的病理性行为,但其中的利培酮口服液治疗方式能更好减轻不良反应,且可提高患者的治疗依从性,值得推广和应用。 展开更多
关键词 利培酮口服液 痴呆患者 病理性行为 临床疗效
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Application of rational emotive behavior therapy in patients with colorectal cancer undergoing adjuvant chemotherapy 被引量:5
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作者 Yuxin Liu Xiaoyan Ni +2 位作者 Rong Wang Huini Liu Zifen Guo 《International Journal of Nursing Sciences》 CSCD 2022年第2期147-154,I0002,I0003,共10页
Objective:This study aimed to explore the effects of our rational emotive behavior therapy(REBT)program on symptoms,anxiety,depression,and sleep state in patients with colorectal cancer(CRC)undergoing chemotherapy.Met... Objective:This study aimed to explore the effects of our rational emotive behavior therapy(REBT)program on symptoms,anxiety,depression,and sleep state in patients with colorectal cancer(CRC)undergoing chemotherapy.Methods:From October 2020 to May 2021,fifty-six patients with CRC in a hospital in the Hunan Province were randomly divided into an intervention group(n=28)and a control group(n=28).The patients in the intervention group completed a 6-week REBT program based on routine nursing care,including four courses:1)establish a relationship and formulate health files;2)group communications and study symptom management;3)continuously provide health knowledge and strengthen healthy behavior;and 4)review the treatment and summary.The control group maintained routine nursing care.The simplified Chinese version of the Memorial Symptom Assessment Scale Short Form(MSASeSFeSC),the Hospital Anxiety and Depression Scale(HADS),and the Pittsburgh Sleep Quality Index(PSQI)scale were used to investigate and compare the intervention effects of the two groups at baseline(T1,before the intervention),four weeks(T2),and six weeks(T3)after the intervention.Results:The intervention group was significantly improved in symptoms,anxiety,depression,and sleep state,compared with the control group.At T2,MSASeSFeSC(24.43±4.26 vs.28.07±3.91),symptom distress(17.29±4.04 vs.19.39±3.59),symptom frequency(7.14±1.51 vs.8.68±1.42),HADS(13.68±3.38 vs.15.86±3.79),anxiety(3.89±1.85 vs.5.18±2.18),and depression(9.79±2.06 vs.10.68±2.23),showed that the difference between the two groups was statistically significant(P<0.05).At T3,MSASeSFeSC(23.89±3.54 vs.30.14±3.94),symptom distress(17.61±3.52 vs.21.32±3.57),symptom frequency(6.29±1.49 vs.8.82±1.47),HADS(11.82±2.57 vs.16.29±3.13),anxiety(3.21±1.64 vs.5.61±1.77),and depression(8.61±1.52 vs.10.68±1.81),showed that the difference between the two groups was statistically significant(P<0.05).The sleep state of the intervention group was better than the control group at T3,with decreased score of PSQI[4.00(3.00,8.00)vs.9.00(7.00,12.50),Z=-3.706,P<0.001].Conclusion:The 6-week REBT program can effectively improve the symptom,anxiety,depression,and sleep state of patients with CRC undergoing chemotherapy,which could as a care plan for patients with CRC who are repeatedly admitted to the hospital for chemotherapy. 展开更多
关键词 ANXIETY Adjuvant chemoradiotherapy Colorectal neoplasms DEPRESSION PATIENTS Rational emotive behavior therapy
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Evaluation of Self Management Behavior of Chronic Kidney Disease Patients
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作者 Sook Hui Phua Nur Akmar Taha +1 位作者 Kiew Bing Pau Wei Yen Kong 《Journal of Pharmacy and Pharmacology》 2017年第4期179-188,共10页
CKD (chronic kidney disease) is a progressive disease. If it is left untreated, it can eventually result in end stage renal failure and necessitate dialysis or kidney transplantation. There is no cure for CKD; inste... CKD (chronic kidney disease) is a progressive disease. If it is left untreated, it can eventually result in end stage renal failure and necessitate dialysis or kidney transplantation. There is no cure for CKD; instead a great deal of self management over time is essential. The purpose is to evaluate self management behaviour of patients at different stages of CKD. A total of 300 CKD patients were recruited in this cross sectional study from March to July 2015 at nephrology clinic of a tertiary care setting using convenience sampling. Self management behaviour score was determined using in Partners in Health scale and was then compared at different stages of CKD. Demographic and clinical factors contributing to self management behaviour were determined. Results: There was a significant difference in age (p 〈 0.001), gender (p 〈 0.001), education level (p 〈 0.001), marital status (p 〈 0.001), duration of illness (p 〈 0.001) and number of co-morbidities (p 〈 0.001) among CKD stages. A significant difference in self management behaviour mean score was found among CKD stages (p 〈 0.001). Post hoc analysis showed self management behaviour mean score for Stage Ⅰ (mean ± SD: 77.81 ± 9.41) was significantly higher than Stage Ⅳ (mean ± SD: 70.53 ± 13.91) and Stage Ⅴ (mean ± SD: 69.54 ± 12.31). Self management behaviour mean score for Stage Ⅱ (mean ± SD: 78.46 ± 10.01) was significantly higher than Stage Ⅳ and Stage Ⅴ. Multiple linear regression revealed education level (p 〈 0.001) and number of co-morbidities (p = 0.01) as significant predictors of self management behaviour. It can be concluded that special attention should be focused on patients at late stage of CKD, especially those with diabetic nephropathy; low education level and multiple co-morbidities to improve self management behaviour. 展开更多
关键词 Self management behaviour chronic kidney disease PREDICTORS demographic factors clinical factors.
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