The gonadal histopathology, and its correlation with the clinical features has been investigated in 9 true hermaphroditism patients, aged 5-21 yr. Seven of 9 patients had been raised as females, of which the chromosom...The gonadal histopathology, and its correlation with the clinical features has been investigated in 9 true hermaphroditism patients, aged 5-21 yr. Seven of 9 patients had been raised as females, of which the chromosomal karyotype was 46XX in 5 cases, 46XX/46XY and 46XX/47XXY in 2 cases. Two of 9 pa- tients were raised as males, the chromosomal karyotypes being 46XX and 46XX/46XY. All 9 patients had testicular tissue excised, and biopsies of the conserved ovarian tissue were performed. Ovotestis was the most common form of the abnormal gonads; two of 9 patients had bilateral ovotestes, seven had unilateral ovotestes (5 in right side, 2 in left side). In seven patients with a unilateral ovotestis, 6 had a contralateral ovary and one had a contralateral testis. Microscopically, the ovarian tissue of 11 ovotestes, including 6 biopsies from contealateral ovaris, were normal, with many primordal follicles and a few growing follicles. In two of the patients, aged over 15 years, evidence of ovulation was observed. In comparison, the testicu- lar tissue of the ovotestis and the one left inguinal testis was histologically abnormal, with immature semi- niferous tubules, most of which filled with Sertoli cells only. Three of 9 patients married after surgical treatment. Two of these subsequently conceived and delivered of normal infants by cesarean section.展开更多
Duodenal duplication,a rare congenital malformation,can also be observed in adulthood.Although it can be cystic or tubular,communicating or non-communicating,cystic and non-communicating forms are the most common.Seve...Duodenal duplication,a rare congenital malformation,can also be observed in adulthood.Although it can be cystic or tubular,communicating or non-communicating,cystic and non-communicating forms are the most common.Several complications,such as obstruction,bleeding,perforation and pancreatitis,may result.Optimal treatment is total excision,although endoscopic procedures have also been described in appropriate cases.If total excision is not possible,subtotal excision and internal derivation can be performed.The 38-year-old woman presented here had occasional attacks of abdominal pain and obstruction,and we considered the diagnosis of duodenal duplication by abdominal computerized tomography.As we confirmed the diagnosis with operative findings and histopathological signs,we treated her with subtotal excision and intraduodenal cystoduodenostomy.展开更多
文摘The gonadal histopathology, and its correlation with the clinical features has been investigated in 9 true hermaphroditism patients, aged 5-21 yr. Seven of 9 patients had been raised as females, of which the chromosomal karyotype was 46XX in 5 cases, 46XX/46XY and 46XX/47XXY in 2 cases. Two of 9 pa- tients were raised as males, the chromosomal karyotypes being 46XX and 46XX/46XY. All 9 patients had testicular tissue excised, and biopsies of the conserved ovarian tissue were performed. Ovotestis was the most common form of the abnormal gonads; two of 9 patients had bilateral ovotestes, seven had unilateral ovotestes (5 in right side, 2 in left side). In seven patients with a unilateral ovotestis, 6 had a contralateral ovary and one had a contralateral testis. Microscopically, the ovarian tissue of 11 ovotestes, including 6 biopsies from contealateral ovaris, were normal, with many primordal follicles and a few growing follicles. In two of the patients, aged over 15 years, evidence of ovulation was observed. In comparison, the testicu- lar tissue of the ovotestis and the one left inguinal testis was histologically abnormal, with immature semi- niferous tubules, most of which filled with Sertoli cells only. Three of 9 patients married after surgical treatment. Two of these subsequently conceived and delivered of normal infants by cesarean section.
文摘Duodenal duplication,a rare congenital malformation,can also be observed in adulthood.Although it can be cystic or tubular,communicating or non-communicating,cystic and non-communicating forms are the most common.Several complications,such as obstruction,bleeding,perforation and pancreatitis,may result.Optimal treatment is total excision,although endoscopic procedures have also been described in appropriate cases.If total excision is not possible,subtotal excision and internal derivation can be performed.The 38-year-old woman presented here had occasional attacks of abdominal pain and obstruction,and we considered the diagnosis of duodenal duplication by abdominal computerized tomography.As we confirmed the diagnosis with operative findings and histopathological signs,we treated her with subtotal excision and intraduodenal cystoduodenostomy.
