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病理组织大切片技术在肺癌的临床分析 被引量:2
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作者 胡国梅 《吉林医学》 CAS 2015年第8期1575-1575,共1页
目的:探讨病理组织大切片技术在非小细胞肺癌组织异质性分析中的应用效果。方法:选择80例非小细胞肺癌标本作为研究对象,将其制成病理组织大切片,进行HE染色,染色后进行Cg A、Syn、NSE表达检测,根据检测结果进行病理诊断。结果:腺癌41例... 目的:探讨病理组织大切片技术在非小细胞肺癌组织异质性分析中的应用效果。方法:选择80例非小细胞肺癌标本作为研究对象,将其制成病理组织大切片,进行HE染色,染色后进行Cg A、Syn、NSE表达检测,根据检测结果进行病理诊断。结果:腺癌41例(51.25%)、鳞癌19例(23.75%)、腺鳞癌30例(37.50%);单一组织类型表现46例(57.50%),有2种或2种以上组织类型34例(42.50%)。Syn阳性23例,占28.75%,Cg A阳性24例,占30.0%。NE(神经内分泌分化)阳性者36例(45.0%),腺癌标本的NE阳性率显著高于腺鳞癌及鳞癌,差异有统计学意义(P<0.05)。80例标本中,有51例有异质性表现,异质性肿瘤比例为63.75%。结论:非小细胞肺癌组织的一个重要特征就是异质性,应用病理组织大切片技术,可全面观察肿瘤组织类型,了解肿瘤细胞异质性,从而为病理诊断提供可靠依据。 展开更多
关键词 病理组织大切片 非小细胞肺癌 异质性
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肺癌病理大切片技术的应用与价值研究
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作者 李成之 《中国卫生标准管理》 2022年第9期63-65,共3页
目的观察肺癌病理大切片技术的应用和临床价值分析。方法临床选择2019年5月—2020年2月在医院接受诊治的非小细胞肺癌患者80例的组织标本,制成病理组织大切片,予以HE染色,染色后予以血清神经元特异性烯醇化酶(neuron specific enolase,N... 目的观察肺癌病理大切片技术的应用和临床价值分析。方法临床选择2019年5月—2020年2月在医院接受诊治的非小细胞肺癌患者80例的组织标本,制成病理组织大切片,予以HE染色,染色后予以血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、突触素(synaptophysin,Syn)、嗜铬素A(chromogranin A,CgA)等免疫标志物检测,根据其检测结果分析病理切片诊断,分析非小细胞肺癌的病理大切片诊断结果。结果非小细胞肺癌患者80例中,腺鳞癌14例(17.5%),鳞癌17例(21.3%),腺癌49例(61.3%),其中多种组织类型者37例(46.3%),单一组织类型表现者43例(53.8%);其中腺癌标本的NSE阳性、CgA阳性、Syn阳性指标显著高于腺鳞癌、鳞癌,差异有统计学意义(P<0.05);非小细胞肺癌病理切片神经元特异性烯醇化酶(NSE)、突触素(Syn)、嗜铬素A(CgA)诊断符合率与病理结果比较,差异无统计学意义(P>0.05)。结论对非小细胞肺癌患者进行病理组织大切片检查,可对肿瘤组织的状态进行全面监测,分析肿瘤细胞的异质性有助于为后续治疗及病理诊断提供准确的依据。 展开更多
关键词 应用价值 病理组织大切片技术 非小细胞肺癌 神经元特异性烯醇化酶 突触素 嗜铬素A
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Effects of sulfasalazme on biopsy mucosal pathologies and histological grading of patients with active ulcerative colitis 被引量:4
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作者 Ying-Qiang Zhong Zhao-Hua Zhu +3 位作者 Qi-Kui Chen Jun Zhan Hua-Rong Huang Lian-Chun Xing 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第28期4435-4438,共4页
AIM: To investigate the mechanisms of sulfasalazine (SASP) in the treatment of ulcerative colitis (UC).METHODS: Changes of pathological signs and histological grading of 106 patients with active UC were observed... AIM: To investigate the mechanisms of sulfasalazine (SASP) in the treatment of ulcerative colitis (UC).METHODS: Changes of pathological signs and histological grading of 106 patients with active UC were observed before and after the treatment with SASP, 1 g, thrice daily for 6 wk.RESULTS: The effect of SASP on the vasculitis in lamina propria was 48.2% and 17.4% in the mild active UC (P〈0.001) and 68% and 26.7% in the moderate active UC (P〈0.001) before and after treatment, Fibroid necrosis of vessel wail was found in one case of mild UC and two cases of moderate UC before treatment and was not found after treatment, No thrombosis was found in mild UC before and after treatment, while thrombosis was found in one case of moderate UC before treatment, The effect on mucosal glandular abnormality was 30.4% and 13.0% in mild UC (P〈0.05), and 42% and 40% in moderate UC (P〉0.05) before and after treatment, The rate of eosinophil infiltration was 98.2% and 80,4% in mild UC (P〈0.01),and 100% and 91,1% in moderate UC (P〈0.05) before and after treatment, The effect on crypt abscess was 21.4% and 4.4% in mild UC (P〈0.05), and 48% and 13.3% in moderate UC (P〈0.001) before and after treatment. The effect on mucosal pathohistological grading was 2.00±0.84 and 0.91±0.46 in mild UC (P〈0.001), and 2.49±0.84 and 1.31±0.75 in moderate UC (P〈0.001) before and after treatment.CONCLUSION: SASP can improve small vessel lesions and crypt abscesses and reduce neutrophilic and eosinophilic leukocyte infiltration in inflammatory mucosa of UC. 展开更多
关键词 UlceraUve colitis Biopsy mucosae SULFASALAZINE PATHOLOGY
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