时辰药理学在合理用药中的应用

时辰药理学又称时间药理学,它通过研究药物在体内代谢及效应过程的周期性变化及药物对机体各种生理病理节律的影响,制定最佳给药时间。使药物给药时间与人体生理节律同步化,以达最佳疗效,并可避免某些药物因持续高浓度而产生耐受性及不良反应,进而使临床治疗疾病更加科学化。

Experimental gastric dysrhythmias and its correlation with in vivo gastric muscle contractions

AIM： To study the direct correlation between gastric dysrhythrnias and in vivo gastric muscle tone. METHODS： Five healthy dogs were implanted with 4 pairs of electrodes along the greater curvature, with a strain gauge （SG） being sutured parallel to the distal electrodes （2 cm above the pylorus）. Intravenous vasopressin was given to induce gastric dysrhythrnia. The percentage of regular slow waves and SG energy were calculated. RESULTS： （1） the regularity of gastric rnyoelectric activity （GMA） was reduced during and after infusion of vasopressin; （2） SG energy was significantly decreased during the infusion of vasopressin; （3） the decrease in SG energy was well correlated with the reduction in GMA regularity; （4） SG energy was negatively correlated with bradygastria and tachygastria. CONCLUSION： Vasopressin inhibits gastric contractions and impairs gastric slow waves; gastric dysrhythrnias are associated with the reduced antral muscle contractions, and are indicative of antral hypornotility.

浅谈时间医学问题

中医时间治疗有着悠久的历史，其内容是中医治疗学不可分割的重要组成部分。它的形成除了和古人对人体生理病理的研究认识水平有关外，还与古代天文、历法的发展水平密切相关，特别是还与古人的“天人相应”哲学思想分不开，当时认为人和天地自然都来源于气，受着阴阳、五行规律的支配，因此人和自然具有相通或相类的关系。