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三叉神经痛模型大鼠的疼痛状况与脑内兴奋性氨基酸递质表达的相关性 被引量:3
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作者 刘艳春 韦彦锋 李家伟 《临床和实验医学杂志》 2019年第7期683-686,共4页
目的探讨三叉神经痛(TN)模型大鼠的疼痛状况与脑内兴奋性氨基酸递质表达的相关性。方法健康SD大鼠32只随机分为对照组16只与模型组16只,模型组于大鼠背部皮下注射硝酸甘油建立TM模型,对照组在大鼠背部皮下注射生理盐水。观察与记录大鼠... 目的探讨三叉神经痛(TN)模型大鼠的疼痛状况与脑内兴奋性氨基酸递质表达的相关性。方法健康SD大鼠32只随机分为对照组16只与模型组16只,模型组于大鼠背部皮下注射硝酸甘油建立TM模型,对照组在大鼠背部皮下注射生理盐水。观察与记录大鼠不同时间段的行为与疼痛状况,采用免疫组化法检测谷氨酸的表达并进行相关性分析。结果模型组大鼠在造模后30 min内都出现挠头、爬笼、耳红等症状,对照组大鼠未出现上述行为变化,表明造模成功。在不同时间段内,模型组的挠头与爬笼次数显著多于对照组(P <0.05)。造模前两组大鼠痛觉反应阈值对比无显著差异(P> 0.05),模型组造模后3~7 d的痛觉反应阈值显著高于对照组(P <0.05)。模型组大鼠三叉神经节的细胞内谷氨酸蛋白的表达高于显著对照组,差异有显著性(P <0.05)。在模型组中,直线相关分析显示造模后7d大鼠的谷氨酸蛋白表达水平与疼痛反应阈值呈正相关性(P <0.05)。结论 TN模型大鼠的疼痛状况与脑内兴奋性氨基酸递质-谷氨酸表达有显著相关性,谷氨酸可能与TN的痛觉传递过程有关。 展开更多
关键词 大鼠 三叉神经痛 谷氨酸 痛觉反应阈值 相关性
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Analysis of the pain threshold at the acupoints on the medial crus in pelvic inflammatory disease 被引量:5
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作者 Jiang-yun WU Yi-ni SUN +4 位作者 Qing-chen ZHOU Lei WANG,Zhi-hong WEN Xue-si HOU Shu-han QU Yi-fan JIAb,Ji-ping ZHAOb 《World Journal of Acupuncture-Moxibustion》 CSCD 2018年第3期204-208,I0006,共6页
Objective: To explore the tenderness response at the acupoints on the medial crus in the patients of pelvic inflammatory disease.Methods: A total of 30 patients of pelvic inflammation and 30 healthy people were incl... Objective: To explore the tenderness response at the acupoints on the medial crus in the patients of pelvic inflammatory disease.Methods: A total of 30 patients of pelvic inflammation and 30 healthy people were included. WAGNER FDX body mechanics algometer was used to determine the score of the visual analogue scale(VAS) and tenderness threshold value at Yīnlíngquán(阴陵泉 SP 9), Sānyīnjiāo(三阴交SP 6) and Lígōu(蠡沟 LR 5).The changes in the tenderness on the body surface at the relevant acupoints were compared and analyzed in the patients of pelvic inflammation.Results: The occurrence rate of tenderness at LR 5 at the pelvic inflammation group was higher significantly than the health group(86% Vs 42%, P0.01). In SP 9, SP 6 and LR 5,the VAS scores at the acupoints in the pelvic inflammation group were higher significantly than the health group(test 1:55.00± 15.12 vs 27.25 ± 10.31,47.07 ± 18.38 vs 29.75 ± 14.30, 47.16 ± 19.4 vs 20.16 ±10.76; test2:53.40± 17.23 vs 33.42± 13.07, 45.95 ± 15.74 vs 29.15± 11.97, 42.50± 21.67 vs 21.05 ± 11.97; test 3:48.50± 14.97 vs 40.08 ± 13.20, 38.24± 15.29 vs 29.29± 12.37, 37.93± 19.17 vs 23.09± 12.26), P〈0.01,P〈0.05.In SP 9, SP 6 and LR 5,the tenderness threshold values at the acupoints in the pelvic inflammation group were higher significantly than the health group(test 1:0.86 ± 0.95 vs 0.53 ± 0.39, 0.86 士 0.95 vs 0.53 ±0.39, 0.85 ± 0.77 vs 0.47 ± 0.47; test 2:0.88 ± 0.81 vs 0.44 ± 0.32, 0.98 ± 0.83 vs 0. 44 ± 0. 32,0.85±0.77 vs 0.47±0.47; test 3:0.98±0.80 vs 0.36±0.26, 1.11 ±0.92 vs 0. 36±0. 26,0.85±0.77 vs0.47 ± 0.47), P〈0.01,P〈0.05(P〈0.05).Conclusion: The VAS scores and tenderness threshold values at SP 9, SP 6 and LR 5 in the patients of pelvic inflammation are higher significantly than those in the healthy people. The occurrence rate of tenderness at LR 5 is higher significantly as compared with the healthy people. 展开更多
关键词 Pelvic inflammation Pain response Visual analogue scale Tenderness threshold value
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