温针灸对坐骨神经痛患者痛阈值的影响

目的观察温针灸对坐骨神经痛患者痛阈值的影响,探索将痛阈值作为判断坐骨神经痛疗效的量化标准的可行性。方法将90例病人随机分为3组,每组30例。温针灸组取肾俞、大肠俞、环跳等穴,施以温针灸;西药组口服尼美舒利片;穴位注射组用654-2作穴位注射,取穴同温针灸组。结果3组治愈率分别为56·67%、26·67%、20·00%;3组总有效率分别为90·00%、73·33%、63·33%。温针灸组疗效优于西药组、穴位注射组(均P<0·01)。温针灸组痛阈值平均上升幅度优于西药组、穴位注射组(均P<0·01)。结论温针灸治疗坐骨神经痛能使痛阈值升高,改善临床症状,提高患者生活质量。

缝隙连接蛋白Cx43基因在针刺镇痛中的作用

目的:探讨缝隙连接蛋白Cx43与针刺镇痛作用的相关性。方法:选用缝隙连接蛋白Cx43基因敲除小鼠,随机分为4组:野生型(widetype,WT)对照组、野生型针刺组、杂合子(heterozy-gous,HT)对照组、杂合子针刺组。分别通过热板、扭体法致痛,观察针刺对杂合子和野生型小鼠镇痛作用的不同效应。结果:杂合子和野生型小鼠的基础痛阈值差异无显著性意义(P>0.05)。针刺能明显提高野生型和杂合子小鼠热板致痛的痛阈值;延长首次扭体潜伏期,减少扭体反应次数,与针刺前相比,差异分别有非常显著(P<0.01)和显著性意义(P<0.05)。针刺后,杂合子小鼠的痛阈值、首次扭体潜伏期和扭体反应次数与野生型相比,差异有显著性意义(P<0.05)。结论:敲除缝隙连接蛋白Cx43基因可部分抑制针刺镇痛效应,提示Cx43与经络及针刺镇痛效应具有一定的相关性。

THE ROLE OF CONNEXIN 43 GENE IN ACUPUNCTURE ANALGESIA

Objective To and connexin 43. Methods investigate the possible relationship between the analgesic effect of acupuncture Connexin 43 gene knock-out mice were randomly divided into 4 groups： a wide type （WT） control group, a WT acupuncture group, a heterozygous （HT） control group and HT acupuncture group. Hot-plate test and writhing response induced by acetic acid were used for investigating the different analgesic effect of acupuncture on HT and WT mice. Results There was no significant difference in the basic pain threshold value between HT and WT mice （P 〉0.05）. Acupuncture could significantly increase the pain threshold value, prolong the latency period of writhing body and decrease the number of writhing body as compared with pre-acupuncture in WT and HT mice （P 〈 0.01 or P 〈 0.05）. The pain threshold, latency period of writhing and number of writhing body in HT mice were less than WT mice post-acupuncture （P〈0.05）. Conclusion Connexin 43 gene knock-out might partially inhibit the analgesic effect of acupuncture, suggesting that connexin 43 is possibly related with meridians and the effect of acupuncture.