血管性痴呆病因病机与发病机制研究概况

血管性痴呆(vascular dementia,VD)属中医学"呆病"、"痴证"等范畴,为肾精亏虚-髓海不足、痰、浊(水湿)-瘀血等蒙蔽(阻)脑窍、玄府郁阻、浊毒内侵、本虚标实、气血亏虚、三焦气化失司、伏邪内生-损害元神、脏腑功能失调、络脉学说;病理机制包括中枢胆碱能、兴奋性氨基酸、氧自由基、神经细胞凋亡、细胞和分子(海马Ca2+、钙调素CaM依赖性蛋白激酶Ⅱ-CaMPKⅡ,内皮素-1-ET-1降钙素)、炎性反应、遗传机制、危险等。中医虽然对血管性痴呆发病原因论述较多,但机理尚未明确,未能达成共识,亦有待于临床与实验进一步检验,对呆病诊断也需扩展其内涵。认为现代医学虽在科研上取得一些研究成果,但也存在一定问题,未来应统一实验标准、设计严谨科研方案等,指导临床VD治疗,判断治法方药优劣性及稳定性。

A CLINICAL TRIAL ON YU CONG TANG IN TREATMENT OF SENILE DEMENTIA

Yu Cong Tang ([symbol: see text]), a TCM decoction, was used to treat senile dementia. It has the action of invigorating the spleen, reinforcing the kidney, nourishing yin, strengthening yang, improving blood circulation, dredging the channels, removing phlegm and restoring consciousness. CT, EEG, REG, Hb, PaO2, Tch, TG and 17-OHCS were tested, showing significant differences (P