目的搔抓动作表现为手腕的加速度变化,采用加速度记录仪以手表形式佩戴于利侧手腕客观定量化评价特应性皮炎(atopic dermatitis,AD)瘙痒程度。方法健康志愿者与AD患者连续佩戴加速度记录仪记录手腕的加速度变化,设定ZCM模式第13型Mini-M...目的搔抓动作表现为手腕的加速度变化,采用加速度记录仪以手表形式佩戴于利侧手腕客观定量化评价特应性皮炎(atopic dermatitis,AD)瘙痒程度。方法健康志愿者与AD患者连续佩戴加速度记录仪记录手腕的加速度变化,设定ZCM模式第13型Mini-Motionlogger作为分析参数。为排除非瘙痒引起的干扰,采用夜间睡眠期的变量作为分析对象。评价治疗前后湿疹面积及严重度指数评分(eczema area and severity index,EASI)、视觉模拟评分(visual analogue scale,VAS)值变化,观察平均活动量(night activity,NA)和瘙痒时间占总睡眠时间百分比(the percent of itching time,PIT)的变化。并评价三者与皮损EASI评分间的相关性。结果 AD患者夜间睡眠时活动量较健康受试者更为频密。AD患者治疗前后NA的前后差值(△)与EASI评分的前后差值(△)相关性较低(P>0.05,r=0.42);VAS评分的前后差值与EASI评分的前后差值几乎没有线性关系(P>0.05,r=0.34);而PIT的前后差值与EASI评分的前后差值则呈直线相关(P<0.05,r=0.75)。结论本研究以健康人的夜间活动量作为基础阈值,计算PIT值,将非瘙痒引起的因素尽可能降低,取得了较好的效果。以PIT值作为分析指标,可取得AD患者夜间搔抓行为相对准确的定量。PIT值与EASI有较高的相关性。展开更多
We have studied nocturnal movements using wrist-worn accelerometers in 33 adu lts with a range of pruritic dermatoses, 30 adult control subjects,25 children w ith atopic dermatitis,and 17 pediatric control subjects. I...We have studied nocturnal movements using wrist-worn accelerometers in 33 adu lts with a range of pruritic dermatoses, 30 adult control subjects,25 children w ith atopic dermatitis,and 17 pediatric control subjects. In all, 26 adults and 2 0 children were studied on more than one occasion, up to a maximum of 6 occasion s. Participants were examined and a range of subjective measures about the exten t of skin disease, itch, and quality of sleep were recorded. We show clear diffe rences between patients and control subjects for both age groups studied, with a ctivity medians approximately twice as high in the patients as in the control su bjects (P < . 001). Studies on the same person show a considerable night-to-ni ght variation that is unlikely to relate to measurement error, but instead, we b elieve, reflect genuine differences in nocturnal activity (and perhaps disease s everity). Movement through the night did not seem to follow any obvious pattern. The relation between subjective measures, Severity sCORing of Atopic Dermatitis (SCORAD)index scores, and objective recorded activity was imperfect, with much unaccounted for variation. In particular, in adults, but not in children, we fou nd a negative correlation (-0.44, P <. 02) between objective movement activity and self-reported quality of sleep. Our results support the use of objective me asures of scratch in the assessment of disease activity,andsuggest that the rela tion between subjective and objective measures of disease severity may not be st raightforward.展开更多
文摘目的搔抓动作表现为手腕的加速度变化,采用加速度记录仪以手表形式佩戴于利侧手腕客观定量化评价特应性皮炎(atopic dermatitis,AD)瘙痒程度。方法健康志愿者与AD患者连续佩戴加速度记录仪记录手腕的加速度变化,设定ZCM模式第13型Mini-Motionlogger作为分析参数。为排除非瘙痒引起的干扰,采用夜间睡眠期的变量作为分析对象。评价治疗前后湿疹面积及严重度指数评分(eczema area and severity index,EASI)、视觉模拟评分(visual analogue scale,VAS)值变化,观察平均活动量(night activity,NA)和瘙痒时间占总睡眠时间百分比(the percent of itching time,PIT)的变化。并评价三者与皮损EASI评分间的相关性。结果 AD患者夜间睡眠时活动量较健康受试者更为频密。AD患者治疗前后NA的前后差值(△)与EASI评分的前后差值(△)相关性较低(P>0.05,r=0.42);VAS评分的前后差值与EASI评分的前后差值几乎没有线性关系(P>0.05,r=0.34);而PIT的前后差值与EASI评分的前后差值则呈直线相关(P<0.05,r=0.75)。结论本研究以健康人的夜间活动量作为基础阈值,计算PIT值,将非瘙痒引起的因素尽可能降低,取得了较好的效果。以PIT值作为分析指标,可取得AD患者夜间搔抓行为相对准确的定量。PIT值与EASI有较高的相关性。
文摘We have studied nocturnal movements using wrist-worn accelerometers in 33 adu lts with a range of pruritic dermatoses, 30 adult control subjects,25 children w ith atopic dermatitis,and 17 pediatric control subjects. In all, 26 adults and 2 0 children were studied on more than one occasion, up to a maximum of 6 occasion s. Participants were examined and a range of subjective measures about the exten t of skin disease, itch, and quality of sleep were recorded. We show clear diffe rences between patients and control subjects for both age groups studied, with a ctivity medians approximately twice as high in the patients as in the control su bjects (P < . 001). Studies on the same person show a considerable night-to-ni ght variation that is unlikely to relate to measurement error, but instead, we b elieve, reflect genuine differences in nocturnal activity (and perhaps disease s everity). Movement through the night did not seem to follow any obvious pattern. The relation between subjective measures, Severity sCORing of Atopic Dermatitis (SCORAD)index scores, and objective recorded activity was imperfect, with much unaccounted for variation. In particular, in adults, but not in children, we fou nd a negative correlation (-0.44, P <. 02) between objective movement activity and self-reported quality of sleep. Our results support the use of objective me asures of scratch in the assessment of disease activity,andsuggest that the rela tion between subjective and objective measures of disease severity may not be st raightforward.
