PURPOSE: To assess the correlation between the serum leptin concentration and ocular involvement in patients with Behcet’s disease. Methods: The study included 28 male consecutive patients with Behcet’s disease (gro...PURPOSE: To assess the correlation between the serum leptin concentration and ocular involvement in patients with Behcet’s disease. Methods: The study included 28 male consecutive patients with Behcet’s disease (group A, aged 19-59, median 35.5 years) and 15 male healthy control subjects (group B, aged 25-45, median 35 years). The body mass index (BMI) was calculated for each subject at the study enrollment stage. We measured serum leptin, neutrophil count and erythrocyte sedimentation rate (ESR). Kruskal-Wallis variance analysis and the Mann-Whitney U-test were used for statistical analysis. Results: The age and BMI between the patients with ocular Behcet’s disease and the control group were not different. White cell count and ESR values were found to be significantly higher among patients with Behcet’s disease and ocular involvement (p< 0.001). The median serum leptin concentrations were as follows: group A: 2.66 (0.57-7.02 ng/ml) and in group B: 2.55 (1.55-7.82 ng/ml). There was no statistically significant difference between the groups. Conclusion: Serum leptin level does not correlate with ocular involvement in patients with Behcet’s disease.展开更多
目的检测哮喘患者的肺功能指标与血清瘦素含量,并明确两者的相关性。方法根据体重指数(body mass index,BMI),将门诊就诊的60例支气管哮喘患者分为两大类:正常体重的哮喘患者(BMI小于等于25/kg/m^2,)和肥胖的哮喘患者(BMI大于25/kg/m^2)...目的检测哮喘患者的肺功能指标与血清瘦素含量,并明确两者的相关性。方法根据体重指数(body mass index,BMI),将门诊就诊的60例支气管哮喘患者分为两大类:正常体重的哮喘患者(BMI小于等于25/kg/m^2,)和肥胖的哮喘患者(BMI大于25/kg/m^2),酶联免疫吸附测定(enzyme linked mmunosorbent assay,ELISA)血清瘦素水平,肺功能仪测量患者用力肺活量(FVC)所占预估值百分率(FVC%pred)和第1秒用力呼气容积(FEV_1)所占预估值百分率(FEV_1%pred),并统计瘦素水平与呼吸功能的相关性。结果与不肥胖的哮喘患者相比,肥胖哮喘的患者FVC%pred和FEV_1%pred等肺功能指标明显下降,血清瘦素含量组明显增长;相关分析发现:血清瘦素水平与哮喘患者FVC%pred和FEV_1%pred呈负相关。结论哮喘患者肺功能与瘦素水平呈负相关。展开更多
文摘PURPOSE: To assess the correlation between the serum leptin concentration and ocular involvement in patients with Behcet’s disease. Methods: The study included 28 male consecutive patients with Behcet’s disease (group A, aged 19-59, median 35.5 years) and 15 male healthy control subjects (group B, aged 25-45, median 35 years). The body mass index (BMI) was calculated for each subject at the study enrollment stage. We measured serum leptin, neutrophil count and erythrocyte sedimentation rate (ESR). Kruskal-Wallis variance analysis and the Mann-Whitney U-test were used for statistical analysis. Results: The age and BMI between the patients with ocular Behcet’s disease and the control group were not different. White cell count and ESR values were found to be significantly higher among patients with Behcet’s disease and ocular involvement (p< 0.001). The median serum leptin concentrations were as follows: group A: 2.66 (0.57-7.02 ng/ml) and in group B: 2.55 (1.55-7.82 ng/ml). There was no statistically significant difference between the groups. Conclusion: Serum leptin level does not correlate with ocular involvement in patients with Behcet’s disease.
