Background and aim: Helicobacter pylori infection and gastric atrophy are both risk factors for gastric cancer. We aimed to elucidate the natural history of gastric cancer development according to H pylori infection a...Background and aim: Helicobacter pylori infection and gastric atrophy are both risk factors for gastric cancer. We aimed to elucidate the natural history of gastric cancer development according to H pylori infection and gastric atrophy status. Subjects and methods: A total of 9293 participants in a mass health appraisal programme were candidates for inclusion in the present prospective cohort study: 6983 subjects revisited the follow up programme. Subjects were classified into four groups according to serological status at initial endoscopy. Group A (n = 3324) had “normal”pepsinogen and were negative for H pylori antibody; group B (n = 2134) had “normal”pepsinogen and were positive for H pylori antibody; group C (n = 1082) had “atrophic”pepsinogen and were positive for H pylori antbody; and group D (n = 443) had “atrophic”pepsinogen and were negative for Hpylori antibody. Incidence of gastric cancer was determined by annual endoscopic examination. Results: Mean duration of follow up was 4.7 years and the average number of endoscopic examinations was 5.1. The annual incidence of gastric cancer was 0.04%(95%confidence interval (CI) 0.02-0.09), 0.06%(0.03-0.13), 0.35%(0.23-0.57), and 0.60%(0.34-1.05) in groups A, B, C, and D, respectively. Hazard ratios compared with group A were 1.1 (95%CI 0.4-3.4), 6.0 (2.4-14.5), and 8.2 (3.2-21.5) in groups B, C, and D, respectively. Age, sex, and “group”significantly served as independent valuables by multivariate analysis. Conclusions: The combination of serum pepsinogen and anti-H pylori antibody provides a good predictive marker for the development of gastric cancer.展开更多
Background: An extremely high prevalence of stomach cancer was observed in Mizoram (India), where the population consumes uncommon food. The relation of food habits and stomach cancer was examined in this study. Metho...Background: An extremely high prevalence of stomach cancer was observed in Mizoram (India), where the population consumes uncommon food. The relation of food habits and stomach cancer was examined in this study. Methods: A hospital-based case-control study was conducted during 2001-2004 to determine the risk factors among 329 patients with histologically confirmed stomach cancer and 658 matched controls. Food habits were determined by personal interview. Results: An elevated risk of stomach cancer was observed with frequent consumption of sa-um [odds ratio (OR) 3.4] (sa-umis fermented pork fat, a traditional food) and with frequent consumption of smoked dried salted meat (OR 2.8) and fish (OR 2.5). Soda (alkali), used as a food additive, increased the risk of stomach cancer (OR 2.9). Helicobacter pylori infection was not found to be an independent risk factor for carcinogenesis of stomach cancer in this study. However, when H. pylori infection interacted with consumption of sa-um or smoked dried meat, it showed a significant association. Conclusion: Peculiar food habits in Mizoram might be associated with the high prevalence of stomach cancer in Mizoram along with other factors. H. pylori infection might increase the risk of stomach cancer, or it may play a role as a promoter of stomach cancer in Mizoram.展开更多
近日,一项发表于国际杂志the Australia and New Zealand Journal of Public Health上的研究论文中,来自奥克兰大学的研究人员通过研究发现,个体患脑瘤的风险或许并不会因为手机使用频率的增加而发生明显改变;文章中,研究者调查了1995年...近日,一项发表于国际杂志the Australia and New Zealand Journal of Public Health上的研究论文中,来自奥克兰大学的研究人员通过研究发现,个体患脑瘤的风险或许并不会因为手机使用频率的增加而发生明显改变;文章中,研究者调查了1995年至2010年间在新西兰原发性脑部癌症发生的趋势。人们都非常关注手机的使用是否会增加个体患脑部肿瘤的风险,研究者指出,通过数据的分析,展开更多
文摘Background and aim: Helicobacter pylori infection and gastric atrophy are both risk factors for gastric cancer. We aimed to elucidate the natural history of gastric cancer development according to H pylori infection and gastric atrophy status. Subjects and methods: A total of 9293 participants in a mass health appraisal programme were candidates for inclusion in the present prospective cohort study: 6983 subjects revisited the follow up programme. Subjects were classified into four groups according to serological status at initial endoscopy. Group A (n = 3324) had “normal”pepsinogen and were negative for H pylori antibody; group B (n = 2134) had “normal”pepsinogen and were positive for H pylori antibody; group C (n = 1082) had “atrophic”pepsinogen and were positive for H pylori antbody; and group D (n = 443) had “atrophic”pepsinogen and were negative for Hpylori antibody. Incidence of gastric cancer was determined by annual endoscopic examination. Results: Mean duration of follow up was 4.7 years and the average number of endoscopic examinations was 5.1. The annual incidence of gastric cancer was 0.04%(95%confidence interval (CI) 0.02-0.09), 0.06%(0.03-0.13), 0.35%(0.23-0.57), and 0.60%(0.34-1.05) in groups A, B, C, and D, respectively. Hazard ratios compared with group A were 1.1 (95%CI 0.4-3.4), 6.0 (2.4-14.5), and 8.2 (3.2-21.5) in groups B, C, and D, respectively. Age, sex, and “group”significantly served as independent valuables by multivariate analysis. Conclusions: The combination of serum pepsinogen and anti-H pylori antibody provides a good predictive marker for the development of gastric cancer.
文摘Background: An extremely high prevalence of stomach cancer was observed in Mizoram (India), where the population consumes uncommon food. The relation of food habits and stomach cancer was examined in this study. Methods: A hospital-based case-control study was conducted during 2001-2004 to determine the risk factors among 329 patients with histologically confirmed stomach cancer and 658 matched controls. Food habits were determined by personal interview. Results: An elevated risk of stomach cancer was observed with frequent consumption of sa-um [odds ratio (OR) 3.4] (sa-umis fermented pork fat, a traditional food) and with frequent consumption of smoked dried salted meat (OR 2.8) and fish (OR 2.5). Soda (alkali), used as a food additive, increased the risk of stomach cancer (OR 2.9). Helicobacter pylori infection was not found to be an independent risk factor for carcinogenesis of stomach cancer in this study. However, when H. pylori infection interacted with consumption of sa-um or smoked dried meat, it showed a significant association. Conclusion: Peculiar food habits in Mizoram might be associated with the high prevalence of stomach cancer in Mizoram along with other factors. H. pylori infection might increase the risk of stomach cancer, or it may play a role as a promoter of stomach cancer in Mizoram.
文摘近日,一项发表于国际杂志the Australia and New Zealand Journal of Public Health上的研究论文中,来自奥克兰大学的研究人员通过研究发现,个体患脑瘤的风险或许并不会因为手机使用频率的增加而发生明显改变;文章中,研究者调查了1995年至2010年间在新西兰原发性脑部癌症发生的趋势。人们都非常关注手机的使用是否会增加个体患脑部肿瘤的风险,研究者指出,通过数据的分析,
