恶性肿瘤是极大危害人类健康的疾病之一，《2008年世界癌症报告》中指出，2000年全球新发癌症病例约1000万，死亡620万，现患病例2200万，预计2020年癌症新发病例将达到1500万，死亡1000万［1］。癌症正在成为新世纪人类的第一杀手，这...恶性肿瘤是极大危害人类健康的疾病之一，《2008年世界癌症报告》中指出，2000年全球新发癌症病例约1000万，死亡620万，现患病例2200万，预计2020年癌症新发病例将达到1500万，死亡1000万［1］。癌症正在成为新世纪人类的第一杀手，这已成为一个全球性的公共健康问题。为此WHO要求各会员国制定国家癌症防控规划，并指出“ If you are not planning，you are planning to fail” Dr．John R．Seffrin［1］。自20世纪20年代末开始，各个国家均致力于肿瘤的防治研究工作［2］。在我国，恶性肿瘤是城市第一位死因，是农村前三位死因疾病之一，恶性肿瘤的预防、早诊早治、及预后已成为急需解决的重点问题之一。近年来，全国各地都在研究探讨建立有效的肿瘤综合防治措施及管理模式［3］。对于肿瘤患者症状的治疗管理，到目前为止，癌症患者症状的治疗主要集中在单一症状的管理，而不是对患者同时存在的症状进行整体治疗，如果要更进一步理解症状之间的关系，进行全程的、综合的、整体的治疗，我们应制定症状管理方法，建立症状管理模式［4］。展开更多
AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the stu...AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus,hypertention,hepatolithiasis,primary sclerosing cholangitis,liver fluke infection (Clonorchis sinensis ),was investigated through clinical records. Blood from all participants was tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies. Odds ratios (OR) and 95% confi dence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with controls,ICC patients had a higher prevalence of HBsAg seropositivity (48.4% vs 9.6%,P < 0.000),and hepatolithiasis (5.4% vs 1.1%,P = 0.001). By multivariate analysis,the signif icant risk factors for development of ICC were HBsAg seropositivity (adjusted OR,8.876,95% CI,5.973-13.192),and hepatolithiasis (adjusted OR,5.765,95% CI,1.972-16.851). The prevalence of anti-HCV seropositivity,diabetes mellitus,hypertention,cigarette smoking,and alcohol consumption were not significantly different between cases and controls. CONCLUSION: These findings suggest that HBV infection and hepatolithiasis are strong risk factors for development of ICC in China.展开更多
文摘恶性肿瘤是极大危害人类健康的疾病之一，《2008年世界癌症报告》中指出，2000年全球新发癌症病例约1000万，死亡620万，现患病例2200万，预计2020年癌症新发病例将达到1500万，死亡1000万［1］。癌症正在成为新世纪人类的第一杀手，这已成为一个全球性的公共健康问题。为此WHO要求各会员国制定国家癌症防控规划，并指出“ If you are not planning，you are planning to fail” Dr．John R．Seffrin［1］。自20世纪20年代末开始，各个国家均致力于肿瘤的防治研究工作［2］。在我国，恶性肿瘤是城市第一位死因，是农村前三位死因疾病之一，恶性肿瘤的预防、早诊早治、及预后已成为急需解决的重点问题之一。近年来，全国各地都在研究探讨建立有效的肿瘤综合防治措施及管理模式［3］。对于肿瘤患者症状的治疗管理，到目前为止，癌症患者症状的治疗主要集中在单一症状的管理，而不是对患者同时存在的症状进行整体治疗，如果要更进一步理解症状之间的关系，进行全程的、综合的、整体的治疗，我们应制定症状管理方法，建立症状管理模式［4］。
文摘AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus,hypertention,hepatolithiasis,primary sclerosing cholangitis,liver fluke infection (Clonorchis sinensis ),was investigated through clinical records. Blood from all participants was tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies. Odds ratios (OR) and 95% confi dence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with controls,ICC patients had a higher prevalence of HBsAg seropositivity (48.4% vs 9.6%,P < 0.000),and hepatolithiasis (5.4% vs 1.1%,P = 0.001). By multivariate analysis,the signif icant risk factors for development of ICC were HBsAg seropositivity (adjusted OR,8.876,95% CI,5.973-13.192),and hepatolithiasis (adjusted OR,5.765,95% CI,1.972-16.851). The prevalence of anti-HCV seropositivity,diabetes mellitus,hypertention,cigarette smoking,and alcohol consumption were not significantly different between cases and controls. CONCLUSION: These findings suggest that HBV infection and hepatolithiasis are strong risk factors for development of ICC in China.
