癌症相关脂肪细胞在肿瘤微环境中的研究进展

肿瘤细胞与肿瘤微环境互相串扰,通过影响基质细胞和基质的成分从而形成一个利于肿瘤发生发展的微环境。脂肪细胞是重要的基质细胞之一,癌症相关脂肪细胞(cancer-associated adipocyte,CAA)是一类表现出恶性表型的脂肪细胞并且与肿瘤细胞相邻,在肿瘤发生发展、侵袭转移和治疗反应的整个过程中都发挥着积极的作用。癌症相关脂肪细胞分泌多种因子以及改变炎症免疫细胞生物学特征和行为参与肿瘤炎症反应和免疫调控;重编程糖、氨基酸、脂质代谢满足肿瘤细胞需求;重塑细胞外基质利于肿瘤细胞进展和转移。此外,癌症相关脂肪细胞还参与了肿瘤耐药机制,阻碍肿瘤治疗效果。因此靶向癌症相关脂肪细胞和肿瘤细胞之间的相互串扰可以为治疗肿瘤提供新的思路。本文综述了肿瘤微环境中癌症相关脂肪细胞的形成,并介绍癌症相关脂肪细胞促进肿瘤进展和耐药的机制以及讨论可能的治疗靶点。

脂肪酸代谢促进乳腺癌转移

脂代谢在乳腺癌转移过程中发挥着重要作用。癌症相关脂肪细胞(cancer-associated adipocyte, CAA)通过分泌游离脂肪酸(FA)和脂质代谢产物,直接参与乳腺癌细胞的脂肪酸代谢,提供能量支持并增强肿瘤的侵袭能力。CAA还分泌多种脂肪因子和炎症因子,激活信号通路,进一步推动乳腺癌的侵袭和转移。与此同时,乳腺癌细胞通过上调脂肪酸合成和氧化的关键酶,增强其侵袭性和转移能力。脂肪酸代谢不仅在原发性肿瘤中起到促进癌细胞侵袭的作用,还在脑、肺等远处转移部位中促进乳腺癌细胞的定植和扩展。本文综述了脂代谢在乳腺癌转移进展中的重要作用,并探讨了脂代谢相关的潜在治疗靶点,为乳腺癌的个性化治疗提供了新的思路。Lipid metabolism plays an important role in breast cancer metastasis. Cancer-associated adipocyte (CAA) is directly involved in fatty acid metabolism of breast cancer cells by secreting free fatty acids (FA) and lipid metabolites, which provide energy support and enhance tumor invasion. CAA also secretes a variety of adipokines and inflammatory factors that activate signaling pathways that further promote breast cancer invasion and metastasis. At the same time, breast cancer cells enhance their invasiveness and metastatic ability by upregulating key enzymes for fatty acid synthesis and oxidation. Fatty acid metabolism plays a role in promoting cancer cell invasion not only in primary tumors, but also in colonization and expansion of breast cancer cells in distant metastatic sites such as brain and lung. This paper reviews the important role of lipid metabolism in the metastatic progression of breast cancer and discusses the potential therapeutic targets related to lipid metabolism, which provides new ideas for personalized treatment of breast cancer.

脂肪细胞在乳腺癌发展及治疗中的相关作用机制研究进展

乳腺癌的发生发展取决于乳腺癌细胞和肿瘤微环境的交互作用。脂肪细胞既是乳腺间质细胞的组成成分,同时也是乳腺癌肿瘤微环境的重要组成部分。其中,位于乳腺癌浸润前沿的癌症相关脂肪细胞,能够通过分泌多种活性因子和相关机制参与乳腺癌的进展和转移。该文作者就脂肪细胞对乳腺癌发展及治疗作用相关机制研究进展进行了综述。