根据基因表达谱数据的特点,提出了全局分量模型(global component model,简称GCM)和癌症组分量模型(cancer component model,简称CCM)两种癌症识别模型.结合GCM模型和CCM模型的互补性,利用基于权值的投票组合策略提出一种基于组合GCM和...根据基因表达谱数据的特点,提出了全局分量模型(global component model,简称GCM)和癌症组分量模型(cancer component model,简称CCM)两种癌症识别模型.结合GCM模型和CCM模型的互补性,利用基于权值的投票组合策略提出一种基于组合GCM和CCM的癌症分类算法(ensemble algorithm based on GCM and CCM for cancer recognition,简称EAGC).在Leukemia,Breast,Prostate,DLBCL,Colon,Ovarian这6个数据集上进行了独立测试实验和交叉测试实验.实验结果表明,EAGC有效地综合了GCM和CCM识别模型的解决方案,弥补了单个分类器的不足,具有较好的泛化性,在所有数据集上都取得较好的分类性能.展开更多
Toll-like receptors （TLRs） are probably the most important class of pattern-recognition receptors. Members of the TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-a...Toll-like receptors （TLRs） are probably the most important class of pattern-recognition receptors. Members of the TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-associated molecular patterns （PAMPs） by TLRs, either alone or in heterodimedzation with other TLR or non-TLR receptors, induces the production of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinflammatory cytokines. Thus, TLRs are involved in the development of many pathological conditions including infectious diseases, tissue damage, and cancer especially. In this review, the contribution of TLRs to tumorgenesis is evaluated. We hope to provide new insight into the progression of cancer and more importantly into the potential for TLRs as targets of therapeutics.展开更多
文摘根据基因表达谱数据的特点,提出了全局分量模型(global component model,简称GCM)和癌症组分量模型(cancer component model,简称CCM)两种癌症识别模型.结合GCM模型和CCM模型的互补性,利用基于权值的投票组合策略提出一种基于组合GCM和CCM的癌症分类算法(ensemble algorithm based on GCM and CCM for cancer recognition,简称EAGC).在Leukemia,Breast,Prostate,DLBCL,Colon,Ovarian这6个数据集上进行了独立测试实验和交叉测试实验.实验结果表明,EAGC有效地综合了GCM和CCM识别模型的解决方案,弥补了单个分类器的不足,具有较好的泛化性,在所有数据集上都取得较好的分类性能.
文摘Toll-like receptors （TLRs） are probably the most important class of pattern-recognition receptors. Members of the TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-associated molecular patterns （PAMPs） by TLRs, either alone or in heterodimedzation with other TLR or non-TLR receptors, induces the production of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinflammatory cytokines. Thus, TLRs are involved in the development of many pathological conditions including infectious diseases, tissue damage, and cancer especially. In this review, the contribution of TLRs to tumorgenesis is evaluated. We hope to provide new insight into the progression of cancer and more importantly into the potential for TLRs as targets of therapeutics.
