皮肤基底细胞癌种植转移临床分析（附3例报告及文献复习）

目的 探讨头面部皮肤基底细胞癌种植转移的致病因素及防治措旆。方法 总结本院在1990年-2002年收治发生于头面部的基底细胞癌56例，其中3例发生邻近组织种植转移，男1例，女2例。均为60岁以上农民。原发灶位于下睑1例、耳前2例。分析种植转移的致病因素、发生发展规律及转归。结果 3例均在首次治疗后1年左右发生种植转移，2例一处转移，1例多处转移。2例随访至今光复发或再转移，1例于再次放射治疗加化疗后1年死亡。结论 头面部基底细胞癌种植转移发生率低5．36％(3／56)，死亡率高33．33％(1／3)。主要致病因素是手术种植、放射线刺激和不良生活习惯所致。

直肠癌种植转移至肛瘘

患者男,61岁,2006年6月囚肛周疼痛流脓于当地医院就诊，诊断为“肛瘘”，行“肛瘘切除术”，术后病理报告示：中分化腺癌。患者当时拒绝进一步检查治疗，肛瘘切口术后5周愈合。2007年10月，因便血伴大便次数增多半年来我院，大便每天7～8次，旱糊状，有时伴少量鲜红血便；无里急后重，无肛周红肿流液。体检：肛门左前陈旧质软手术疤痕．直肠指检示：距肛6cm内未及肿块，指套无染血。

肝细胞癌医源性腹壁种植转移三例临床分析

肝癌经血液等途径的皮肤转移临床少见,但随着有创诊断治疗手段的增加,医源性肝癌种植转移也逐渐增多[1-3].2006年6月至2009年12月我科共收治3例肝癌种植转移患者,报告如下.

原发性肝癌肝移植术后右心房转移一例

原发性肝细胞癌（HCC）转移多见于肝内、肺、骨、淋巴结、肾上腺及腹腔，右心房内种植转移罕见，现报道解放军总医院一例因原发性肝癌行肝移植术后2年余发生右心房内肝癌种植转移病例。

Human breast carcinoma xenografts in nude mice

OBJECTIVE: To investigate spontaneous metastasis, micrometastasis and genetic stability in human breast carcinoma xenografts in nude mice. METHODS: Intact tissue from surgical specimens from breast carcinoma patients was xenografted into nude mice and transplanted from generation to generation. Cells from the xenografts were cultured in vitro and retransplanted into nude mice. Microsatellite DNA in the genome of human breast carcinomas, xenotransplanted tumors and metastases in nude mice were analyzed at three microsatellite loci. RESULTS: The tumorigenicity of orthotopic xenotransplantation was 88.6% (31/35), with a metastatic rate of 41.9% (13/31). Cells from xenotransplants were successfully cultured in vitro. The taking rate of retransplantation into nude mice and the spontaneous lung metastasis rate were both 100% (10/10). Microsatellite DNA sequences in the genome of xenotransplanted tumors and metastases in nude mice were identical with that of the original human breast carcinoma at three microsatellite loci. CONCLUSIONS: Tumorigenicity and metastatic potential can be improved in human breast carcinoma xenografts using intact fresh tumor tissue and orthotopic grafts. Xenotransplanted tumors and tumors after serial passage maintained the genetic stability. The detection of microsatellite DNA may identify micrometastases in a nude mouse model.