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克癌7851抗癌作用的实验研究 被引量:1
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作者 周舒 迟永春 +2 位作者 杜皓萍 陈子馨 刘颖 《中日友好医院学报》 1991年第1期3-7,2,共6页
本文报告了由铜、铁微量元素与清热解毒、活血化瘀中草药组成的克癌7851对小鼠肝癌和肺癌抑制作用。对肝癌抑制率45.9%~73.5%,肺癌34.3%~35.9%。与对照组相比,荷瘤动物活存动态曲线明显抬高,癌细胞分裂指数下降,对照组33.4‰~39.... 本文报告了由铜、铁微量元素与清热解毒、活血化瘀中草药组成的克癌7851对小鼠肝癌和肺癌抑制作用。对肝癌抑制率45.9%~73.5%,肺癌34.3%~35.9%。与对照组相比,荷瘤动物活存动态曲线明显抬高,癌细胞分裂指数下降,对照组33.4‰~39.8‰,给药组19.6‰~24.2‰,癌细胞DNA含量较少,对照组42.9~47.2 A.U.,给药组33.5~41.1 A.U.,组方图明显左移。 展开更多
关键词 克癌7851 抑癌率 癌细胞分裂指数 DNA含量
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Experimental study of gemcitabine combination with radiation in vitro on a highly metastatic human ovarian cancer cell line HO-8910PM
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作者 Linhui Gu Lijuan Qian Chihong Zhu Yutian Ling Hongwei Zhang, Xianglin Liu 《The Chinese-German Journal of Clinical Oncology》 CAS 2010年第11期648-651,共4页
Objective: The aim of the study was to investigate the mechanism of gemcitabine (GEM) combination with radiation on the high metastasis human ovarian cancer cell line (HO-8910PM). Methods: Human ovarian cancer c... Objective: The aim of the study was to investigate the mechanism of gemcitabine (GEM) combination with radiation on the high metastasis human ovarian cancer cell line (HO-8910PM). Methods: Human ovarian cancer cell line HO- 8910PM was treated with different concentrations of gemcitabine for 24 h, then the cells were counted. In the study of GEM combination with radiation, an efficiency of colony formation was observed; the cell cycle and apoptosis were analyzed by flow cytometry; the experiment of depend on the time and its radio sensitivity were observed by using mitotic index with the cells for each 24, 48, 72 and 96 h after experiment. Results: It suggested that the GEM had an inhibition effect on the human ovarian cancer cell line. The alive cell numbers were decreased by following a height of GEM concentration. When GEM in combina- tion with a radiation, the suppression was significantly increased than that of single GEM therapy. The efficiency of colony formation was significantly lower, under this condition the cell could be arrested at G0-G1 phase and could be decreased to enter into the S phase; the apoptosis percentage could be significantly increased; especially, under the 4 Gy and 6 Gy doses the cell apoptosis was more obvious. GEM combination with radiation had depended on the time to the cells; mitotic index of the calls in combination group was observed significantly lower than that of single GEM therapy or single radiation, and this showed that it had an effect of radiosensitivity. Conclusion: The GEM has a significant growth inhibition on the human ovarian cancer cells, GEM combination with radiation could induce HO-8910PM cell occurred arrested and apoptosis. It has depended on the time and has a radiosensitivity effect. The result shows that it is a better method to treat the human ovarian cancer by using radiotherapy combined with gemcitabine. 展开更多
关键词 gemcitabine (GEM) RADIATION human ovarian cancer HO-8910PM cell line
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The Effect of Gnaphafium oxyphyllum var. natalie on Cancer and Blood Cells
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作者 Elisa Vega-Avila Shindu Irais Gomez-Covarrubias +2 位作者 Adolfo Espejo-Sema Elizabeth Hernandez-Perez Maria de los Angeles Aguilar-Santamaria 《Journal of Pharmacy and Pharmacology》 2016年第5期231-239,共9页
Gnaphalium oxyphyllum DC is a medicinal plant whose common uses by Mexican people include the treatment of cancer. The toxicity of the aqueous and organic fractions as well as the aqueous decoction of G. oxyphyllum va... Gnaphalium oxyphyllum DC is a medicinal plant whose common uses by Mexican people include the treatment of cancer. The toxicity of the aqueous and organic fractions as well as the aqueous decoction of G. oxyphyllum var. natalie F. J. Espinosa were assessed on three human cancer cell lines as well as in blood cells in healthy human lymphocyte cultures. Cytotoxic activity was assessed by the Sulforhodamine B method on HeLa (human cervical carcinoma), T47D (human breast carcinoma) and 22Rvl (human prostate carcinoma cancer). Colchicine was used as positive control. The decoction was also tested on lymphocytes from healthy donors through the mitotic index as biomarker. We used whole blood for these cultures and estimated the effect of the extract on platelets, leukocytes and erythrocytes. The aqueous decoction was cytotoxic (EDs0 〈 20 μg/mL) on the three cancer cell lines. The mitotic index in the exposed lymphocyte cultures did not significantly differ from the control nor the blood counts showed any difference between the experimental and control cultures. These results prove that the toxic effect of the aqueous decoction of G. oxyphyllum var. natalie is specific for cancer cell lines. 展开更多
关键词 Gnaphalium oxyphyllum cancer cell lines CYTOTOXICITY lymphocyte culture mitotic index.
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