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癌肿瘤免疫疗法模型的RBF神经网络控制
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作者 马成荣 高华 《绍兴文理学院学报》 2007年第9期22-26,共5页
针对癌肿瘤免疫疗法生物数学模型,基于RBF神经网络和Lyapunov函数,提出了一种控制器设计方案,该方案将逼近误差引入到控制率中以保证控制方法的鲁棒性与稳定性.在外界无扰动与扰动存在两种情况下,分别实现了对癌肿系统的控制.生物医学上... 针对癌肿瘤免疫疗法生物数学模型,基于RBF神经网络和Lyapunov函数,提出了一种控制器设计方案,该方案将逼近误差引入到控制率中以保证控制方法的鲁棒性与稳定性.在外界无扰动与扰动存在两种情况下,分别实现了对癌肿系统的控制.生物医学上即:防止了癌肿瘤的肿大、破裂,使癌肿瘤处于稳定、不易恶化的状态.数值举例表明了控制方法的有效性. 展开更多
关键词 生物数学模型 癌肿瘤免疫疗法 RBF神经网络 LYAPUNOV函数 稳定性
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Expression of HMGB1 Protein in Human Cervical Squamous Epithelium Carcinoma 被引量:4
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作者 付欣 杜晓琴 郝权 《Chinese Journal of Clinical Oncology》 CSCD 2008年第1期53-57,共5页
OBJECTIVE To investigate the expression of the high mobility group boxl(HMGB1) in human cervical squamous epithelial carcinoma (CSEC) and to explore the relationship of HMGB1 expression to the differentiation degr... OBJECTIVE To investigate the expression of the high mobility group boxl(HMGB1) in human cervical squamous epithelial carcinoma (CSEC) and to explore the relationship of HMGB1 expression to the differentiation degree, size, invasion and metastasis of CSEC. METHODS Immunohistochemical staining of tissue microarrays and Western blot analysis were conducted to detect the expression of HMGB1 in the following tissue samples: 30 carcinoma in situ, 90 invasive CSEC without metastasis, 30 invasive CSEC with metastasis, 30 cases of normal cervical squamous epithelia. RESULTS The positive-expression rate of HMGB1 was 58.7% (88/150) in CSEC, showing a significant difference compared to normal cervical squamous epithelia. The expression of HMGB1 was correlated with tumor size, invasion and metastasis of CSEC (respectively, P〈0.01), but had no relationship with the degree of differentiation (P〉0.05). CONCLUSION The over-expression of HMGB1 in CSEC might be a useful parameter as an indication of tumor invasion, metastasis, prognosis and overall biological behavior of human CSEC, as well as a noval target site for gene therapy. 展开更多
关键词 cervical squamous epithelium carcinoma (CSEC) high mobility group box1 HMGB1 IMMUNOHISTOCHEMISTRY Western blot tumor invasion.
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Colon cancer and the immune system:The role of tumor invading T cells 被引量:16
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作者 Maximilian Waldner Carl C Schimanski Markus F Neurath 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第45期7233-7238,共6页
Colon cancer is still one of the leading causes of cancer death worldwide. Although the host immune system has been shown to react against tumor cells, mainly through tumor infi ltrating lymphocytes and NK cells, tumo... Colon cancer is still one of the leading causes of cancer death worldwide. Although the host immune system has been shown to react against tumor cells, mainly through tumor infi ltrating lymphocytes and NK cells, tumor cells may utilize different ways to escape anti-tumor immune response. Tumor infi ltration of CD8+ and CD4+ (T-bet+) effector T cells has been attributed to a beneficial outcome, and the enhancement of T cell activation through T cell receptor stimulation and co-stimulatory signals provides promising strategies for immunotherapy of colon cancer. Growing evidence supports a role for the Fas/FasL system in tumor immunology, although the mechanisms and consequences of FasL activation in colon cancer are not completely understood. In animal models, depletion of regulatory T cells (CD4+ CD25+ T cells) can enhance the anti-tumor immune response under certain conditions. Taken together, recent insights in the immune reaction against colon carcinoma have provided new approaches to immunotherapy, although much remains to be learned about the exact mechanisms. 展开更多
关键词 CD4-positive T-lymphocytes CD8-positive T-lymphocytes IMMUNOLOGY Colonic neoplasms therapy Colorectal neoplasms Humans LYMPHOCYTES Tumor-infiltrating Tumor escape
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