Objective To explore the effects on endocrinal function treated with acupuncture based on Qijie （the pathway of qi） theory in epilepsy patients. Methods A total of 60 epilepsy patients were randomly divided into acu...Objective To explore the effects on endocrinal function treated with acupuncture based on Qijie （the pathway of qi） theory in epilepsy patients. Methods A total of 60 epilepsy patients were randomly divided into acupuncture and medication group （n--30）, and single medication group （n = 30）. Both groups were taken antiepileptic drugs, sodium valproate regularly. The acupoints of Fengfu（风府 GV 16）,TiEmzhu （天柱 BL 10） and Renying （人迎 ST 9） were selected as major points according to Qijie theory （气街理论） in acupuncture and medication group. The plasma levels of cortisol （CORT）, estrogen （E2）, progesterone （Prog）, pituitary prolactin （PRL）, and epilepsy score were observed successively in both enrolled groups in pre-treatment and post-treatment. The outcomes were statistically analyzed. Results The effective rate was 96.7% in either group, and there was no significant differences; the epilepsy score was （13. 584.01） in pre- treatment and （7.86 ___4.90） in post-treatment in acupuncture and medication group and those in single medi- cation group were （12.97 ± 3. 91） and （7. 86 ± 4.90） respectively, indicating apparent improvement （P〈O. 05）. The increase of CORT in acupuncture and medication group indicated significant difference in post-treatment compared with that in single medication group （P = 0.046）. The differences of E2, PRL, Prog in post-treatment in two groups showed no statistical significance （P〉0. 05）. More effects had been a- chieved in acupuncture and medication group on endocrinal function and controlling epileptic seizures in epilepsy patients. Conclusion Acupuncture treatment based on Qijie theory is effective on improving endocrinal function in epilepsy patients.展开更多
Objective： The strategies against epilepsy are currently very limited. The author performed this work to determine the effect of electroacupuncture （EA） on epileptic seizures and define the optimal EA conditions （...Objective： The strategies against epilepsy are currently very limited. The author performed this work to determine the effect of electroacupuncture （EA） on epileptic seizures and define the optimal EA conditions （acupoints and stimulation parameters）. Methods： Experimental epilepsy was induced by injecting kainic acid into the lateral cerebral ventricle of adult male SD rats. EA with a current of 1 mA/100 Hz or 1 mA/10 Hz was applied to the model starting at 0.5 h after the injection for 30 rain. Four pairs of acupoints were tested, including Renzhong （GV 26） ＋ Dazhui （GV 14）, Jinsuo （GV 8） ＋ Yaoqi （Ex-B 9）, Neiguan （PC 6） ＋ Quchi （LI 11） and Fenglong （ST 40） ＋ Yongquan （KI 1）. Results： Behavioral scores showed that （1） either high （100 Hz） or low （10 Hz） frequency EA at different acupoints attenuated epileptic seizures （P〈0.05 or 0.01 vs. the control）, except EA at Neiguan （PC 6） ＋ Quchi （LI 11） with 1 mA/10 Hz current; （2） EA with low frequency stimulation （10 Hz） induced a better effect at Fenglong （ST 40） ＋ Yongquan （KI1） than other acupoints （P〈0.05 or 0.01）; （3） there was no significant difference in EA effects induced by various acupoints when exposed to high frequency EA （100 Hz）; and （4） high frequency EA （100 Hz） elicited a better effect than low frequency EA （10 Hz） in all groups （P〈0.05 or 0.01） except for that of Jinsuo （GV 8） ＋ Yaoqi （Ex-B 9）. EEG showed the similar tendency, i.e., EA generally reduced the amplitude and frequency of epileptic discharges. Conclusion： Electroacupuncture attenuates epileptic seizures, which is relatively specific to EA parameters and acupoints.展开更多
基金subsidized by Guangdong Province Bureau of Traditional Chinese Medicine(NO:103018)
文摘Objective To explore the effects on endocrinal function treated with acupuncture based on Qijie （the pathway of qi） theory in epilepsy patients. Methods A total of 60 epilepsy patients were randomly divided into acupuncture and medication group （n--30）, and single medication group （n = 30）. Both groups were taken antiepileptic drugs, sodium valproate regularly. The acupoints of Fengfu（风府 GV 16）,TiEmzhu （天柱 BL 10） and Renying （人迎 ST 9） were selected as major points according to Qijie theory （气街理论） in acupuncture and medication group. The plasma levels of cortisol （CORT）, estrogen （E2）, progesterone （Prog）, pituitary prolactin （PRL）, and epilepsy score were observed successively in both enrolled groups in pre-treatment and post-treatment. The outcomes were statistically analyzed. Results The effective rate was 96.7% in either group, and there was no significant differences; the epilepsy score was （13. 584.01） in pre- treatment and （7.86 ___4.90） in post-treatment in acupuncture and medication group and those in single medi- cation group were （12.97 ± 3. 91） and （7. 86 ± 4.90） respectively, indicating apparent improvement （P〈O. 05）. The increase of CORT in acupuncture and medication group indicated significant difference in post-treatment compared with that in single medication group （P = 0.046）. The differences of E2, PRL, Prog in post-treatment in two groups showed no statistical significance （P〉0. 05）. More effects had been a- chieved in acupuncture and medication group on endocrinal function and controlling epileptic seizures in epilepsy patients. Conclusion Acupuncture treatment based on Qijie theory is effective on improving endocrinal function in epilepsy patients.
基金the Science Foundation of Shanghai Municipal Commission of Science and Technology(05DZ19745,06DZ19732,064319053,07DZ19722,07DZ19733)the National Basic Research Program of China(973 Program,2005CB523306)+1 种基金Shanghai Leading Academic Discipline Project(B112 and T0302)NIH-HD3485
文摘Objective： The strategies against epilepsy are currently very limited. The author performed this work to determine the effect of electroacupuncture （EA） on epileptic seizures and define the optimal EA conditions （acupoints and stimulation parameters）. Methods： Experimental epilepsy was induced by injecting kainic acid into the lateral cerebral ventricle of adult male SD rats. EA with a current of 1 mA/100 Hz or 1 mA/10 Hz was applied to the model starting at 0.5 h after the injection for 30 rain. Four pairs of acupoints were tested, including Renzhong （GV 26） ＋ Dazhui （GV 14）, Jinsuo （GV 8） ＋ Yaoqi （Ex-B 9）, Neiguan （PC 6） ＋ Quchi （LI 11） and Fenglong （ST 40） ＋ Yongquan （KI 1）. Results： Behavioral scores showed that （1） either high （100 Hz） or low （10 Hz） frequency EA at different acupoints attenuated epileptic seizures （P〈0.05 or 0.01 vs. the control）, except EA at Neiguan （PC 6） ＋ Quchi （LI 11） with 1 mA/10 Hz current; （2） EA with low frequency stimulation （10 Hz） induced a better effect at Fenglong （ST 40） ＋ Yongquan （KI1） than other acupoints （P〈0.05 or 0.01）; （3） there was no significant difference in EA effects induced by various acupoints when exposed to high frequency EA （100 Hz）; and （4） high frequency EA （100 Hz） elicited a better effect than low frequency EA （10 Hz） in all groups （P〈0.05 or 0.01） except for that of Jinsuo （GV 8） ＋ Yaoqi （Ex-B 9）. EEG showed the similar tendency, i.e., EA generally reduced the amplitude and frequency of epileptic discharges. Conclusion： Electroacupuncture attenuates epileptic seizures, which is relatively specific to EA parameters and acupoints.
