由法国、意大利、美国及德国等一众蜚声国际的癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译本--《婴儿、儿童和青少年期癫痫综合征》...由法国、意大利、美国及德国等一众蜚声国际的癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译本--《婴儿、儿童和青少年期癫痫综合征》第六版即将由人民卫生出版社出版。《婴儿、儿童和青少年期癫痫综合征》第六版中文版由暨南大学附属第一医院癫痫中心主任秦兵教授牵头,召集国内一批文笔尚佳的中青年癫痫病学者历时数载。展开更多
由法国、意大利、美国及德国等一众蜚声国际的癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译本——《婴儿、儿童和青少年期癫痫综合征...由法国、意大利、美国及德国等一众蜚声国际的癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译本——《婴儿、儿童和青少年期癫痫综合征》第六版即将由人民卫生出版社出版。展开更多
由法国、意大利、美国、德国等癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译著——《婴儿、儿童和青少年期癫痫综合征》第六版即将由...由法国、意大利、美国、德国等癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译著——《婴儿、儿童和青少年期癫痫综合征》第六版即将由人民卫生出版社出版。展开更多
Gamma-aminobutyric acid(GABA) contributes substantially to neurocognitive function as an important inhibitory neurotransmitter in the human cerebral cortex. However, the pathophysiology of disorders such as epilepsy a...Gamma-aminobutyric acid(GABA) contributes substantially to neurocognitive function as an important inhibitory neurotransmitter in the human cerebral cortex. However, the pathophysiology of disorders such as epilepsy are not well understood, since GABA agonists are not quite effective in treating epilepsy. Knowledge of the mechanism of action of GABA would contribute to review previously proposed anti-epileptic processes by GABA agonists. In this study based on recent experiments on GABAergic astrocytes, we developed a modified GABAergic astrocyte model, and successfully simulated a long-lasting Ca^(2+) oscillation in astrocytes after 0.5-s stimulation of GABAergic transmission. We then incorporated this GABAergic astrocyte model into a classical Ullah-Schiff seizure model and surprisingly found that this GABAergic astrocyte model functions to hinder the anti-epileptic action of GABA agonists, thereby explaining their low efficiency in previous experiments. These results also update our knowledge of the mechanism of action of GABA and the effects of astrocytes on physiological and pathological functions of the brain.展开更多
文摘由法国、意大利、美国及德国等一众蜚声国际的癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译本--《婴儿、儿童和青少年期癫痫综合征》第六版即将由人民卫生出版社出版。《婴儿、儿童和青少年期癫痫综合征》第六版中文版由暨南大学附属第一医院癫痫中心主任秦兵教授牵头,召集国内一批文笔尚佳的中青年癫痫病学者历时数载。
文摘由法国、意大利、美国及德国等一众蜚声国际的癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译本——《婴儿、儿童和青少年期癫痫综合征》第六版即将由人民卫生出版社出版。
文摘由法国、意大利、美国、德国等癫痫病学家主编的世界医学经典名著《Epileptic Syndrome in Infancy,Childhood and Adolescence》第六版(俗称“蓝皮书指南”,Blue Guide)中文版译著——《婴儿、儿童和青少年期癫痫综合征》第六版即将由人民卫生出版社出版。
基金supported by the National Natural Science Foundation of China(Grant No.11472202)
文摘Gamma-aminobutyric acid(GABA) contributes substantially to neurocognitive function as an important inhibitory neurotransmitter in the human cerebral cortex. However, the pathophysiology of disorders such as epilepsy are not well understood, since GABA agonists are not quite effective in treating epilepsy. Knowledge of the mechanism of action of GABA would contribute to review previously proposed anti-epileptic processes by GABA agonists. In this study based on recent experiments on GABAergic astrocytes, we developed a modified GABAergic astrocyte model, and successfully simulated a long-lasting Ca^(2+) oscillation in astrocytes after 0.5-s stimulation of GABAergic transmission. We then incorporated this GABAergic astrocyte model into a classical Ullah-Schiff seizure model and surprisingly found that this GABAergic astrocyte model functions to hinder the anti-epileptic action of GABA agonists, thereby explaining their low efficiency in previous experiments. These results also update our knowledge of the mechanism of action of GABA and the effects of astrocytes on physiological and pathological functions of the brain.
