目的:了解缩短动态脑电图(AEEG)监测时间后对癫诊断的影响。方法:将观察组90例癫患者的AEEG监测时间从24 h缩短为15 h(下午17:00至次晨8:00);对照组90例癫患者则仍进行24 h AEEG监测。结果:观察组与对照组样放电检出率差异无统计学意义(...目的:了解缩短动态脑电图(AEEG)监测时间后对癫诊断的影响。方法:将观察组90例癫患者的AEEG监测时间从24 h缩短为15 h(下午17:00至次晨8:00);对照组90例癫患者则仍进行24 h AEEG监测。结果:观察组与对照组样放电检出率差异无统计学意义(P>0.05)。结论:适当缩短AEEG监测时间不影响癫的诊断,同时可减少病人负担,减轻病人痛苦,方便病人。展开更多
A 62-year-old male with decompensated liver cirrhosis due to hepatitis C virus developed severe hepatic encephalopathy with status epileptic us. The blood ammonia level on admission was more than twice the normal leve...A 62-year-old male with decompensated liver cirrhosis due to hepatitis C virus developed severe hepatic encephalopathy with status epileptic us. The blood ammonia level on admission was more than twice the normal level. Brain computed tomography and magnetic resonance imaging were normal. In addition, electroencephalogram showed diffuse sharp waves, consistent with hepatic encephalopathy. The status epilepticus was resolved after antiepileptic therapy （phenytoin sodium） and treatment for hepatic encephalopathy （Branched chain amino acids）. The blood ammonia level normalized with the clinical improvement and the patient did not have a recurrence of status epilepticus after the end of the antiepileptic treatment. Additionally, the electroencephalogram showed normal findings. Thus, we diagnosed the patient as hepatic encephalopathy with status epilepticus. We consider the status epilepticus of this patient to a rare and interesting finding in hepatic encephalopathy.展开更多
Objective To evaluate the efficacy of electrocorticographic(ECoG) monitoring and the application of different surgical approaches in the surgical treatment of solitary supretentorial cavernous malformations with secon...Objective To evaluate the efficacy of electrocorticographic(ECoG) monitoring and the application of different surgical approaches in the surgical treatment of solitary supretentorial cavernous malformations with secondary epilepsy. Methods This study enrolled a consecutive series of 36 patients with solitary supratentorial cavernous malformations and secondary epilepsy who underwent surgery with intraoperative ECoG monitoring in the Department of Neurosurgery between January 2004 and January 2008. The patients were composed of 15 males and 21 females, aged between 8 and 52 years(mean age 27.3±2.8 years) at the time of surgery. Epilepsy history, the type of epilepsy at the presentation, lesion location, the incidence of residual epileptiform discharges, and postoperative outcomes were evaluated. Results Histopathological examination indicated cavernous malformations and hippocampal sclerosis in 36 and 5 cases, respectively. Neuronal degeneration, glial cell proliferation, and neurofibrillary tangles were found in all the resected cerebral tissues of extended lesionectomy of residual epileptic foci. Lesionectomy, anterior temporal lobectomy, anterior temporal lobectomy plus cortical thermocoagulation, extended lesionectomy, extended lesionectomy plus cortical thermocoagulation were performed in 4, 4, 1, 14, and 13 cases, respectively. Residual epileptiform discharges were captured in 9 out of the 14 patients who had additional cortical thermocoagulation. According to Engle class for postoperative outcomes, 27 cases were class I(75.00%), 5 were class II(13.89%), 2 were class III(5.56%), and 2 were class IV(5.56%), thus the total effective rate(class I+class II) was 88.89%. Neither of epilepsy history, the type of epilepsy, and the location of cavernous malformation was significantly related to outcomes(P>0.05). A significant relationship was found between the incidence of residual epileptiform discharges and outcomes(P=0.041). Conclusions Intraoperative ECoG monitoring, the application of different surgical approaches, and the resection of residual epileptic foci could produce good result in the surgical treatment of supratentorial cavernous malformation with secondary epilepsy. Postoperative residual epileptiform discharges could be a useful predictor for evaluating the outcomes.展开更多
Sleep and waking EEG of 522 patients with epilepsy and various disease with attack nature were studied. EEG showed paroxysmal activities(PA) in 217 cases. PA appeared only during sleep in 96 cases. Posi- tive rate of ...Sleep and waking EEG of 522 patients with epilepsy and various disease with attack nature were studied. EEG showed paroxysmal activities(PA) in 217 cases. PA appeared only during sleep in 96 cases. Posi- tive rate of EEG diagnosis increased from 23. 2 percent in waking recordings to 41. 6 percent. Fifty of 97 benign childhood epilepsy with centrotemporal spike(51. 6% ) had focal PA only during sleep. Two of 6 cases with Lennox-Gastaut syndrome showed tonic seizure and/or generalized paroxysmal fast activities, Seizure types of 15 patients were defined by interictal PA and letal EEG during sleep. There was no corre- sponding relationship between seizure time(waking or sleep) and PA sensitivity to state of vigilance.展开更多
ELECTROCORTICOGRAPHY (ECoG), the intraoperative recording of cortical potentials, has played an important role in the surgical management of patients with medically intractable epilepsy. This technique is useful in ep...ELECTROCORTICOGRAPHY (ECoG), the intraoperative recording of cortical potentials, has played an important role in the surgical management of patients with medically intractable epilepsy. This technique is useful in epilepsy surgery to delineate margins of epileptogenic zones, guide resection,展开更多
Aim: To observe the therapeutic effect of acupoint catgut embedding in the treatment of epilepsy rats. Methods: 40 Wistar rats were randomly and evenly divided into normal control, model, medication (Natrii Valproas s...Aim: To observe the therapeutic effect of acupoint catgut embedding in the treatment of epilepsy rats. Methods: 40 Wistar rats were randomly and evenly divided into normal control, model, medication (Natrii Valproas syrup), and catgut embedding groups. Epilepsy model was established by intraperitoneal injection of sodium penicillin (0.4 mu/100 g), twice every week, continuously for 4 weeks. Electroencephalograph (EEG) was used as the index for assessing the effect of catgut embedding on epilepsy. Results: In epilepsy rats of model group, the amplitude and frequency of EEG increased significantly in comparison with control group (P<0.05). While the amplitude and frequency of EEG of catgut embedding group and medication group were all significantly lower than those of model group (P<0.05, 0.01). The frequency of EEG of catgut embedding group was significantly lower than that of medication group (P<0.05). These findings show that both acupoint catgut embedding and medication can apparently improve epileptic electrical activities of the brain in the rat, and the effect of catgut embedding is better than that of medication in lowering the frequency of EEG.展开更多
文摘目的:了解缩短动态脑电图(AEEG)监测时间后对癫诊断的影响。方法:将观察组90例癫患者的AEEG监测时间从24 h缩短为15 h(下午17:00至次晨8:00);对照组90例癫患者则仍进行24 h AEEG监测。结果:观察组与对照组样放电检出率差异无统计学意义(P>0.05)。结论:适当缩短AEEG监测时间不影响癫的诊断,同时可减少病人负担,减轻病人痛苦,方便病人。
文摘A 62-year-old male with decompensated liver cirrhosis due to hepatitis C virus developed severe hepatic encephalopathy with status epileptic us. The blood ammonia level on admission was more than twice the normal level. Brain computed tomography and magnetic resonance imaging were normal. In addition, electroencephalogram showed diffuse sharp waves, consistent with hepatic encephalopathy. The status epilepticus was resolved after antiepileptic therapy （phenytoin sodium） and treatment for hepatic encephalopathy （Branched chain amino acids）. The blood ammonia level normalized with the clinical improvement and the patient did not have a recurrence of status epilepticus after the end of the antiepileptic treatment. Additionally, the electroencephalogram showed normal findings. Thus, we diagnosed the patient as hepatic encephalopathy with status epilepticus. We consider the status epilepticus of this patient to a rare and interesting finding in hepatic encephalopathy.
文摘Objective To evaluate the efficacy of electrocorticographic(ECoG) monitoring and the application of different surgical approaches in the surgical treatment of solitary supretentorial cavernous malformations with secondary epilepsy. Methods This study enrolled a consecutive series of 36 patients with solitary supratentorial cavernous malformations and secondary epilepsy who underwent surgery with intraoperative ECoG monitoring in the Department of Neurosurgery between January 2004 and January 2008. The patients were composed of 15 males and 21 females, aged between 8 and 52 years(mean age 27.3±2.8 years) at the time of surgery. Epilepsy history, the type of epilepsy at the presentation, lesion location, the incidence of residual epileptiform discharges, and postoperative outcomes were evaluated. Results Histopathological examination indicated cavernous malformations and hippocampal sclerosis in 36 and 5 cases, respectively. Neuronal degeneration, glial cell proliferation, and neurofibrillary tangles were found in all the resected cerebral tissues of extended lesionectomy of residual epileptic foci. Lesionectomy, anterior temporal lobectomy, anterior temporal lobectomy plus cortical thermocoagulation, extended lesionectomy, extended lesionectomy plus cortical thermocoagulation were performed in 4, 4, 1, 14, and 13 cases, respectively. Residual epileptiform discharges were captured in 9 out of the 14 patients who had additional cortical thermocoagulation. According to Engle class for postoperative outcomes, 27 cases were class I(75.00%), 5 were class II(13.89%), 2 were class III(5.56%), and 2 were class IV(5.56%), thus the total effective rate(class I+class II) was 88.89%. Neither of epilepsy history, the type of epilepsy, and the location of cavernous malformation was significantly related to outcomes(P>0.05). A significant relationship was found between the incidence of residual epileptiform discharges and outcomes(P=0.041). Conclusions Intraoperative ECoG monitoring, the application of different surgical approaches, and the resection of residual epileptic foci could produce good result in the surgical treatment of supratentorial cavernous malformation with secondary epilepsy. Postoperative residual epileptiform discharges could be a useful predictor for evaluating the outcomes.
文摘Sleep and waking EEG of 522 patients with epilepsy and various disease with attack nature were studied. EEG showed paroxysmal activities(PA) in 217 cases. PA appeared only during sleep in 96 cases. Posi- tive rate of EEG diagnosis increased from 23. 2 percent in waking recordings to 41. 6 percent. Fifty of 97 benign childhood epilepsy with centrotemporal spike(51. 6% ) had focal PA only during sleep. Two of 6 cases with Lennox-Gastaut syndrome showed tonic seizure and/or generalized paroxysmal fast activities, Seizure types of 15 patients were defined by interictal PA and letal EEG during sleep. There was no corre- sponding relationship between seizure time(waking or sleep) and PA sensitivity to state of vigilance.
文摘ELECTROCORTICOGRAPHY (ECoG), the intraoperative recording of cortical potentials, has played an important role in the surgical management of patients with medically intractable epilepsy. This technique is useful in epilepsy surgery to delineate margins of epileptogenic zones, guide resection,
文摘Aim: To observe the therapeutic effect of acupoint catgut embedding in the treatment of epilepsy rats. Methods: 40 Wistar rats were randomly and evenly divided into normal control, model, medication (Natrii Valproas syrup), and catgut embedding groups. Epilepsy model was established by intraperitoneal injection of sodium penicillin (0.4 mu/100 g), twice every week, continuously for 4 weeks. Electroencephalograph (EEG) was used as the index for assessing the effect of catgut embedding on epilepsy. Results: In epilepsy rats of model group, the amplitude and frequency of EEG increased significantly in comparison with control group (P<0.05). While the amplitude and frequency of EEG of catgut embedding group and medication group were all significantly lower than those of model group (P<0.05, 0.01). The frequency of EEG of catgut embedding group was significantly lower than that of medication group (P<0.05). These findings show that both acupoint catgut embedding and medication can apparently improve epileptic electrical activities of the brain in the rat, and the effect of catgut embedding is better than that of medication in lowering the frequency of EEG.
