目的观察肾白宁治疗肝肾亏虚、瘀血湿浊型糖尿病肾病的临床疗效。方法将80例肝肾亏虚、瘀血湿浊型糖尿病肾病患者随机分为治疗组和对照组,每组各40例。治疗组予肾白宁水丸,对照组予洛汀新,疗程3个月。观察治疗前后总有效率及空腹血糖(F...目的观察肾白宁治疗肝肾亏虚、瘀血湿浊型糖尿病肾病的临床疗效。方法将80例肝肾亏虚、瘀血湿浊型糖尿病肾病患者随机分为治疗组和对照组,每组各40例。治疗组予肾白宁水丸,对照组予洛汀新,疗程3个月。观察治疗前后总有效率及空腹血糖(FBG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb A1c),24 h Upro、UAER。结果治疗组与对照组治疗后综合疗效比较,治疗组总有效率为89.47%,对照组总有效率为66.67%,治疗组优于对照组(P<0.01);肾白宁治疗组患者治疗后24 h Upro、UAER水平均明显降低,优于对照组(P<0.05)。结论肾白宁益肾敛精,化瘀泄浊,能明显减少糖尿病肾病患者的尿蛋白排泄。展开更多
目的:观察肾白宁对糖尿病肾病大鼠ACE2蛋白及基因表达的影响。方法:采用左侧肾脏摘除+STZ诱发DN大鼠模型,将成模大鼠随机分为4组:假手术组、模型组、对照组、中药组。中药组将肾白宁浸膏溶于生理盐水,配制成混悬液,予以2.97 g·(kg&...目的:观察肾白宁对糖尿病肾病大鼠ACE2蛋白及基因表达的影响。方法:采用左侧肾脏摘除+STZ诱发DN大鼠模型,将成模大鼠随机分为4组:假手术组、模型组、对照组、中药组。中药组将肾白宁浸膏溶于生理盐水,配制成混悬液,予以2.97 g·(kg·d)^(-1),2 m L混悬液灌胃;对照组将盐酸贝那普利溶于生理盐水,配制成混悬液,予以中等剂量0.9mg·(kg·d)^(-1),2 m L混悬液灌胃;模型组及假手术组予以等体积生理盐水,1次·d-1,灌胃,观察12周。检测大鼠肾脏组织ACE2蛋白及基因表达。结果:与假手术组比较,模型组、对照组、中药组ACE2蛋白及基因表达水平明显降低,差异具有统计学意义(P<0.01)。与模型组比较,对照组、中药组ACE2蛋白及基因表达水平明显升高,差异有统计学意义(P<0.05或P<0.01)。与对照组比较,中药组ACE2蛋白表达水平明显升高,差异具有统计学意义(P<0.05);ACE2基因表达水平升高,但差异无统计学意义(P>0.05)。结论:肾白宁能明显升高糖尿病肾病模型大鼠肾脏组织ACE2蛋白及基因表达,从而起到拮抗肾脏纤维化,延缓大鼠糖尿病肾病进展的作用。展开更多
The Jianchang Basin is one of the main localities of the precious fossils of Jehol Biota in western Liaoning.The fossil-bearing horizons are mainly in the Yixian-and Jiufotang formations.In the Weijialing--Yaolugou of...The Jianchang Basin is one of the main localities of the precious fossils of Jehol Biota in western Liaoning.The fossil-bearing horizons are mainly in the Yixian-and Jiufotang formations.In the Weijialing--Yaolugou of southwest Jianchang Basin,many precious fossils have been found at Luojiagou Bed of the 2nd Member of the Yixian Formation and at Xidian Bed of the 1st member of the Jiufotang Formation.The geologic setting,sedimentary environment and paleogeography of the precious fossil-bearing beds were also studied.展开更多
文摘目的观察肾白宁治疗肝肾亏虚、瘀血湿浊型糖尿病肾病的临床疗效。方法将80例肝肾亏虚、瘀血湿浊型糖尿病肾病患者随机分为治疗组和对照组,每组各40例。治疗组予肾白宁水丸,对照组予洛汀新,疗程3个月。观察治疗前后总有效率及空腹血糖(FBG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb A1c),24 h Upro、UAER。结果治疗组与对照组治疗后综合疗效比较,治疗组总有效率为89.47%,对照组总有效率为66.67%,治疗组优于对照组(P<0.01);肾白宁治疗组患者治疗后24 h Upro、UAER水平均明显降低,优于对照组(P<0.05)。结论肾白宁益肾敛精,化瘀泄浊,能明显减少糖尿病肾病患者的尿蛋白排泄。
文摘目的:观察肾白宁对糖尿病肾病大鼠ACE2蛋白及基因表达的影响。方法:采用左侧肾脏摘除+STZ诱发DN大鼠模型,将成模大鼠随机分为4组:假手术组、模型组、对照组、中药组。中药组将肾白宁浸膏溶于生理盐水,配制成混悬液,予以2.97 g·(kg·d)^(-1),2 m L混悬液灌胃;对照组将盐酸贝那普利溶于生理盐水,配制成混悬液,予以中等剂量0.9mg·(kg·d)^(-1),2 m L混悬液灌胃;模型组及假手术组予以等体积生理盐水,1次·d-1,灌胃,观察12周。检测大鼠肾脏组织ACE2蛋白及基因表达。结果:与假手术组比较,模型组、对照组、中药组ACE2蛋白及基因表达水平明显降低,差异具有统计学意义(P<0.01)。与模型组比较,对照组、中药组ACE2蛋白及基因表达水平明显升高,差异有统计学意义(P<0.05或P<0.01)。与对照组比较,中药组ACE2蛋白表达水平明显升高,差异具有统计学意义(P<0.05);ACE2基因表达水平升高,但差异无统计学意义(P>0.05)。结论:肾白宁能明显升高糖尿病肾病模型大鼠肾脏组织ACE2蛋白及基因表达,从而起到拮抗肾脏纤维化,延缓大鼠糖尿病肾病进展的作用。
基金Supported by Projects of the State Key Laboratory of Geological Processes and Mineral Resources,China University of Geosciences(No.GPMR200603)Project of Education Bureau of Liaoning Province(No.20060805)
文摘The Jianchang Basin is one of the main localities of the precious fossils of Jehol Biota in western Liaoning.The fossil-bearing horizons are mainly in the Yixian-and Jiufotang formations.In the Weijialing--Yaolugou of southwest Jianchang Basin,many precious fossils have been found at Luojiagou Bed of the 2nd Member of the Yixian Formation and at Xidian Bed of the 1st member of the Jiufotang Formation.The geologic setting,sedimentary environment and paleogeography of the precious fossil-bearing beds were also studied.
