308nm准分子激光治疗白癜风皮肤病进展

临床研究表明波长308 nm准分子激光治疗白癜风皮肤病效果明显。治疗效果与病人的性别、年龄、病程没有明显关联,但与皮肤类型、皮损部位、治疗频度和疗程等有明显关联。在一定剂量范围内随治疗剂量和治疗时间增加治疗效果越来越明显,呈线性变化。而皮损部位的影响,疗效从明显到不明显的顺序是:面部,颈部和头皮,生殖器,四肢,躯干,手脚或肢端关节。皮肤类型对治疗效果影响明显。另外,在一定的观察时间内发现308 nm准分子激光疗效明显高于NB UVB。

PD-1抗体治疗肺癌出现白癜风样皮肤反应和免疫检查点抑制剂相关性肺炎一例

肺癌是世界上发病率和死亡率最高的恶性肿瘤之一。GLOBOCAN 2018数据显示,2018年约有1810万例癌症新发病例和960万例癌症死亡病例;其中,肺癌是发病率最高的癌症之一,也是导致死亡的主要原因之一[1]。按照组织病理学分类,肺癌可分为小细胞肺癌和非小细胞肺癌(non-small-cell lung cancer,NSCLC)[2]。NSCLC约占肺癌的85%~90%。腺癌是最常见的亚型[3]。>60%的新诊断NSCLC患者在确诊时已出现局部或远处转移,从而失去手术机会。免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已发展为晚期NSCLC患者的一线治疗方法[4]。

自体表皮移植及皮肤磨削术治疗白癜风的疗效观察和护理

目的探讨自体表皮移植及皮肤磨削术治疗白癜风的疗效和护理经验。方法术前给患者做好心理护理。采用BY-1ICM型表皮移植器。高温负压起疱及皮肤磨削术治疗110例白癜风患者。结果治愈80．90％，显效93．63％，无效6．37％。结论此方法治疗稳定期局限型及节段型白癖风疗程短，治愈率高，安全，副作用小。

Study of neuropeptide Y in the plasma and skin tissue of patients with vitiligo

Objective: To study the role of neuropeptide Y (NPY) in the pathogenesis of vitiligo. Methods: The levels of NPY in the plasma from patients with vitiligo and healthy volunteers were measured by 125I RIA Kit. The expression of NPY in normal skin tissues, uninvolved tissues and lesional tissues of vitiligo was detected by immunohistochemistry. Results: The levels of NPY in the patients with vitiligo of all types were significantly higher than that in the normal controls. In all types, the levels in active stage were significantly higher than those in stable stage. The expression of NPY was upregulated in lesions of patients with active vitiligo (P<0.01) compared with those in normal skin tissues and uninvolved tissues. There was significant difference of NPY expression between active stage and stable stage (P<0.01). Conclusion: These findings support the concept of neuropeptide involvement in vitiligo, especially in active vitiligo, and suggest that NPY may play a role in the pathogenesis of this disease.