细胞因子与免疫性疾病

细胞因子的研究已取得了突破性进展,它们对生理与病理过程的重要性已无可置疑,对临床医学的影响及应用已令人关注。与免疫细胞和免疫应答相关的细胞因子大致可分为6类:（1）白细胞介素系统（interleu-kin system）IL-1—IL-13;（2）干扰素族（family of interferons）IFN-α,-β,-γ;（3）肿瘤坏死因子（tumor necrosis factors）TNF-α,-β;（4）集落刺激因子（colony stimulatingfactors）G-CSF,M-CSF,GM-CSF,Multi—CSF;（5）其它特定的细胞生长因子（cell growth factors）,如转化生长因子（TGF-α,-β1,-β2,-γ）,表皮生长因子（EGF）、成纤维细胞生长因子（FGF）。

系统性红斑狼疮患者外周血IL-10和TGF-β1的表达及与抗双链DNA抗体的相关性分析

目的检测系统性红斑狼疮(SLE)患者外周血白细胞介素-10(IL-10)和转化生长因子-β1(TGF-β1)的表达水平,并探讨其与抗双链DNA抗体的相关性。方法选取50例SLE患者进行研究,根据临床SLEDAI计分表2000版分为活动组(23例)和稳定组(27例),收集30例健康体检者为对照组,检测3组患者外周血IL-10和TGF-β1水平和抗双链DNA抗体。结果活动组患者的外周血IL-10和TGF-β1水平明显高于稳定组和对照组患者(P<0.05);稳定组患者的外周血IL-10水平明显高于对照组患者(P<0.05),TGF-β1水平比较差异无统计学意义;SLE患者外周血IL-10表达水平与抗双链DNA抗体的反应呈正相关(r=0.367,P=0.030),TGF-β1表达水平与抗双链DNA抗体无相关性(r=0.318,P>0.05)。结论 SLE患者的发病可能与外周血IL-10存在密切关系。

Interleukin-6 polymorphisms modify the risk of periodontitis: a systematic review and meta-analysis

Objective： To clarify the association ofIL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. Material and methods： We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 -174 G/C and -572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 -6331 TIC polymorphism and the risk of periodontitis was adequately reviewed as well. Results and conclusion： The present meta-analysis indicates that the IL-6 -174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And -572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.