Background Cartilage oligomeric matrix protein （COMP） is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could al...Background Cartilage oligomeric matrix protein （COMP） is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could also inhibit vascular calcification. We investigated the serum COMPs in coronary heart disease （CHD） patients, and the relationship between serum COMP and the calcification of coronary artery. Methods A total of 233 consecutive chest pain patients who first underwent coronary angiography followed by multi-slice computed to- mography （MSCT） within six months were recruited and divided into two groups according to the coronary angiography luminal diameter narrowing percentages： CHD group （diameter narrowing 〉 50%, n = 194） and control group （diameter narrowing 〈 50%, n = 39）. The Gen- sini score, Syntax score and coronary artery calcium score （CACs） were calculated. The serum COMP level was determined using ELISA. Results The levels of COMP were significantly higher in the CHD group than in the control group 155.7 （124.5-194.5） ng/mL vs. 128.4 （113.0-159.9） ng/mL, P = 0.019. There were no correlation between COMP, Gensini score, Syntax score, severity of coronary stenosis and the number of coronary artery with stenosis 〉 50%. The serum COMP was correlated with age （r = 0.294, P 〈 0.001）, fasting glucose （r = 0.163, P = 0.015）, HbAlc （r = 0.194, P = 0.015） and CACs （r = 0.137, P = 0.037）. Stepwise linear regression analysis showed that COMP level and age were independent predictors of CACs in the CHD patients （fl = 0.402, t = 2.612, P = 0.015; fl = 0.472, t = 3.077, P = 0.005）. Performance of COMP for predicting CHD was shown as area under curve （AUC）： 0.632, 95% CI： 0.549-0.715 and upper tertile CACs was AUC： 0.602, 95% CI： 0.5264）.678 in receiver operating characteristic （ROC） curve analysis. Conclusion Calcification of coronary artery was an independent predictor of serum COMPs.展开更多
Objective To evaluate the relationship between plasma apoA Ⅳ levels and coronary atherosclerosis and to explore its relation to other risk factors Methods Using ELISA techniques, plasma apoA Ⅳ levels were quant...Objective To evaluate the relationship between plasma apoA Ⅳ levels and coronary atherosclerosis and to explore its relation to other risk factors Methods Using ELISA techniques, plasma apoA Ⅳ levels were quantified in 181 patients who underwent coronary angiography (CAG) Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n=118) and a control group (normal CAG, n=63) The severity of atherosclerosis was assessed by stenosis scoring of the different lesions Other parameters, including apoA Ⅰ, apoB, Lp(a), HDL C, LDL C, TG, and TC, were measured as well Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA Ⅳ levels Results When compared with the control group, plasma apoA Ⅳ levels were found to be lower in the CHD group There was a weak negative correlation between plasma apoA Ⅳ levels and the severity of coronary atherosclerosis ApoA Ⅳ was found to be a relatively independent risk factor for CHD We also found a positive correlation between apoA Ⅳ and triglyceride levels Conclusions ApoA Ⅳ may be important in the prediction of CHD and coronary atherosclerosis severity It may also play an important role in the metabolism of triglycerides展开更多
文摘Background Cartilage oligomeric matrix protein （COMP） is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could also inhibit vascular calcification. We investigated the serum COMPs in coronary heart disease （CHD） patients, and the relationship between serum COMP and the calcification of coronary artery. Methods A total of 233 consecutive chest pain patients who first underwent coronary angiography followed by multi-slice computed to- mography （MSCT） within six months were recruited and divided into two groups according to the coronary angiography luminal diameter narrowing percentages： CHD group （diameter narrowing 〉 50%, n = 194） and control group （diameter narrowing 〈 50%, n = 39）. The Gen- sini score, Syntax score and coronary artery calcium score （CACs） were calculated. The serum COMP level was determined using ELISA. Results The levels of COMP were significantly higher in the CHD group than in the control group 155.7 （124.5-194.5） ng/mL vs. 128.4 （113.0-159.9） ng/mL, P = 0.019. There were no correlation between COMP, Gensini score, Syntax score, severity of coronary stenosis and the number of coronary artery with stenosis 〉 50%. The serum COMP was correlated with age （r = 0.294, P 〈 0.001）, fasting glucose （r = 0.163, P = 0.015）, HbAlc （r = 0.194, P = 0.015） and CACs （r = 0.137, P = 0.037）. Stepwise linear regression analysis showed that COMP level and age were independent predictors of CACs in the CHD patients （fl = 0.402, t = 2.612, P = 0.015; fl = 0.472, t = 3.077, P = 0.005）. Performance of COMP for predicting CHD was shown as area under curve （AUC）： 0.632, 95% CI： 0.549-0.715 and upper tertile CACs was AUC： 0.602, 95% CI： 0.5264）.678 in receiver operating characteristic （ROC） curve analysis. Conclusion Calcification of coronary artery was an independent predictor of serum COMPs.
文摘Objective To evaluate the relationship between plasma apoA Ⅳ levels and coronary atherosclerosis and to explore its relation to other risk factors Methods Using ELISA techniques, plasma apoA Ⅳ levels were quantified in 181 patients who underwent coronary angiography (CAG) Patients were divided according to their coronary status into a coronary heart disease (CHD) group (stenotic lesion on CAG, n=118) and a control group (normal CAG, n=63) The severity of atherosclerosis was assessed by stenosis scoring of the different lesions Other parameters, including apoA Ⅰ, apoB, Lp(a), HDL C, LDL C, TG, and TC, were measured as well Univariate, logistic regression analyses were used to define the relationship between coronary atherosclerosis and plasma apoA Ⅳ levels Results When compared with the control group, plasma apoA Ⅳ levels were found to be lower in the CHD group There was a weak negative correlation between plasma apoA Ⅳ levels and the severity of coronary atherosclerosis ApoA Ⅳ was found to be a relatively independent risk factor for CHD We also found a positive correlation between apoA Ⅳ and triglyceride levels Conclusions ApoA Ⅳ may be important in the prediction of CHD and coronary atherosclerosis severity It may also play an important role in the metabolism of triglycerides
